ENPROFYLLINE

Product Name: ENPROFYLLINE
CAS No.: 41078-02-8
Chemical Name: ENPROFYLLINE
Synonyms: d-4028;nilyph;Enprofilina;ENPROFYLLINE;ENPROPHYLLINE;Enprofyllilie;Enprofyllinum;3-PROPYLXANTHINE;3-Propylxanthfine;3-N-PROPYLXANTHINE
CBNumber: CB0108540
Molecular Formula: C8H10N4O2
Formula Weight: 194.19
MOL File: 41078-02-8.mol

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ENPROFYLLINE Property

Melting point:: 287-289 °C
Density: 1.38 g/cm3
storage temp.: 2-8°C
solubility: DMSO: soluble
form: solid
pka: 10.26±0.20(Predicted)
color: white
CAS DataBase Reference: 41078-02-8

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
WGK Germany: 3
RTECS: UO8439700

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21746
Product name: 3-Propylxanthine
Purity: ≥95%
Packaging: 10mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21746
Product name: 3-Propylxanthine
Purity: ≥95%
Packaging: 25mg
Price: $78
Updated: 2024/03/01

Cayman Chemical

Product number: 21746
Product name: 3-Propylxanthine
Purity: ≥95%
Packaging: 50mg
Price: $139
Updated: 2024/03/01

TRC

Product number: E557680
Product name: Enprofylline
Packaging: 10mg
Price: $160
Updated: 2021/12/16

AK Scientific

Product number: E974
Product name: Enprofylline
Packaging: 25mg
Price: $185
Updated: 2021/12/16

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ENPROFYLLINE Chemical Properties,Usage,Production

Description

3-Propylxanthine is a xanthine derivative that antagonizes adenosine receptors (K_is = 44, 32, and 6.3 μM for A₁, A_2A, and A_2B, respectively) and cAMP phosphodiesterase (K_i = 42 μM). Through these actions, 3-propylxanthine induces smooth muscle relaxation, blocks smooth muscle contraction and VEGF secretion driven by adenosine receptor agonists, and reduces bronchial hyperresponsiveness.

Uses

Bronchodilator.

Uses

Enprofylline is a xanthine lacking adenosine receptor antagonism.

Definition

ChEBI: Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic n uropathy.

in vivo

Enprofylline increases heart rate (HR). Injection of Enprofylline (7.5 and 30 mg/kg) increases HR in male WT mouse from 529±23 to 590±20 and 562±20 after the low and high dose, respectively^[3].
A high dose of Enprofylline (30 mg/kg) also decreases temperature compared with saline injection in female (but not in males) WT mice, but a low dose (7.5 mg/kg) has little effect on mouse temperature^[3].

Animal Model:	A1RKO mice (were cross-bred to C57BL/6 mice for six generations) and A2ARKO mice (were backcrossed to C57BL/6 mice for more than 10 generations)^[3]
Dosage:	30 mg/kg
Administration:	Intraperitoneally injected (bolus) at 2-h intervals
Result:	Increased HR in male WT mouse from 529±23 to 590±20 and 562±20 after the low (7.5 mg/kg) and high dose (30 mg/kg), respectively.

IC 50

A2B receptor: 7 μM (Ki)

References

[1] J LINDEN. Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.[J]. Molecular Pharmacology, 1999, 56 4: 705-713.
[2] K. OGAWA T. S K Takagi. Mechanism of xanthine-induced relaxation of guinea-pig isolated trachealis muscle[J]. British Journal of Pharmacology, 1989, 97 2: 542-546. DOI: 10.1111/j.1476-5381.1989.tb11983.x
[3] U SCHWABE M J L D Ukena. Xanthine derivatives as antagonists at A1 and A2 adenosine receptors.[J]. Naunyn-Schmiedeberg’s archives of pharmacology, 1985, 330 3: 212-221. DOI: 10.1007/bf00572436
[4] BIRGITTE H?IER. Contraction-induced secretion of VEGF from skeletal muscle cells is mediated by adenosine.[J]. American journal of physiology. Heart and circulatory physiology, 2010: H857-62. DOI: 10.1152/ajpheart.00082.2010
[5] G H KO?TER. Effect of theophylline and enprofylline on bronchial hyperresponsiveness.[J]. Thorax, 1989, 44 12: 1022-1026. DOI: 10.1136/thx.44.12.1022

ENPROFYLLINE Preparation Products And Raw materials

Raw materials

Cyanoacetic acid

Preparation Products

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ENPROFYLLINE Suppliers

China 44 Europe 2 Germany 1 India 1 Russia 1 South Korea 1 Switzerland 1 United Kingdom 3 United States 13 USA 1 Global 68

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
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Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
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Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

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View Lastest Price from ENPROFYLLINE manufacturers

Career Henan Chemical Co

Product: ENPROFYLLINE 41078-02-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-14

41078-02-8, ENPROFYLLINERelated Search:

1,3-DIPROPYL-8-P-SULFOPHENYLXANTHINE 3-ISOBUTYL-1-METHYLXANTHINE ENPROFYLLINE Cipamfylline 1,3-Dipropyl-7-methylxanthine Verofylline Denbufylline 1,3-DI-N-BUTYLXANTHINE CPX, [DIPROPYL-2,3-3H] 8-METHOXYMETHYL-3-ISOBUTYL-1-METHYLXANTHINE 8-CYCLOPENTYL-1,3-DIPROPYLXANTHINE 1,3-DIPROPYL-8-PHENYLXANTHINE 8-[2-(4-benzhydrylpiperazin-1-yl)ethyl]-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione XANTHINE AMINE CONGENER Mexafylline CYCLOPENTYL-1,3-DIPROPYLXANTHINE, 8-[DIPROPYL-2,3-3H(N)]- 1,3-DIPROPYL-8-(2-AMINO-4-CHLOROPHENYL)-XANTHINE 1,3-Diisobutyl-8-methylxanthine

3-Propylxanthfine

Enprofyllilie

3-propyl-7H-purine-2,6-dione

3-propyl-7H-purine-2,6-quinone

1H-Purine-2,6-dione, 3,9-dihydro-3-propyl-

ENPROPHYLLINE

3-Propyl-1H-purine-2,6(3H,7H)-dione

3-N-PROPYLXANTHINE

3-PROPYLXANTHINE

ENPROFYLLINE

3,7-dihydro-3-propyl-1h-purine-2,6-dione

3-Propyl 3,7-dihydro-1H-purine-2,6-dione

3-Propyl-7H-purine-2,6(1H,3H)-dione

3,7-dihydro-3-propyl-1h-purine-6-dione

d-4028

nilyph

3,9-dihydro-3-propyl-purine-2,6-dione

Enprofilina

Enprofyllinum

3-propyl-2,3,6,7-tetrahydro-1H-purin-2,6-dione

chronic obstructive pulmonary,interleukin-8,A2B receptor antagonist,phosphodiesterase inhibitor,Enprofylline,Adenosine Receptor,Adenosine,inhibit,asthma,Inhibitor,phospholipase C,P1 receptor,Phosphodiesterase (PDE)

3,9-Dihydro-3-propyl-1H-purin-2,6-dione

Enprofylline, 10 mM in DMSO

3-Propyl-1H-purin-2,6(3H,7H)-dione

41078-02-8