ChemicalBook > CAS DataBase List > Bucladesine sodium

Bucladesine sodium

Product Name
Bucladesine sodium
CAS No.
16980-89-5
Chemical Name
Bucladesine sodium
Synonyms
DC 2797;,5ÕDBcAMP-Na;N6-2ÕPrestwick_32;CAMP, DB-, NA;BUCLADESINE NA;dt5621sodiumsalt;DIB-3:5-CAMP, NA;bucladesinesodium
CBNumber
CB8236166
Molecular Formula
C18H25N5NaO8P
Formula Weight
493.39
MOL File
16980-89-5.mol
More
Less

Bucladesine sodium Property

Melting point:
>173°C (dec.)
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
white
Merck 
14,1463
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey
DBXVIQJWMFGXGO-AOTDUVMNNA-N
SMILES
O([C@@H]1[C@]2([H])OP(O)(=O)OC[C@@]2([H])O[C@H]1N1C=NC2C(=NC=NC1=2)NC(=O)CCC)C(=O)CCC.[NaH] |&1:1,2,10,13,r|
More
Less

Safety

Safety Statements 
24/25
WGK Germany 
2
RTECS 
ES5055500
F 
10-21
HS Code 
29349990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
28745-M
Product name
Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem
Purity
This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging
25mg
Price
$136
Updated
2024/03/01
Sigma-Aldrich
Product number
28745-M
Product name
Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem
Purity
This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging
100mg
Price
$418
Updated
2024/03/01
Sigma-Aldrich
Product number
28745-M
Product name
Adenosine 3′,5′-cyclic Monophosphate, N⁶,O<sup>2′</sup>-Dibutyryl-, Sodium Salt
Purity
This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging
1g
Price
$1250
Updated
2024/03/01
Sigma-Aldrich
Product number
28745-M
Product name
Adenosine 3′,5′-cyclic Monophosphate, N⁶,O2′-Dibutyryl-, Sodium Salt
Purity
This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging
28745-1GM
Price
$1220
Updated
2023/06/20
TCI Chemical
Product number
D4228
Product name
N6,2'-O-Dibutyryladenosine 3',5'-Cyclic Monophosphate Sodium Salt
Purity
>97.0%(HPLC)
Packaging
25mg
Price
$121
Updated
2024/03/01
More
Less

Bucladesine sodium Chemical Properties,Usage,Production

Description

Bucladesine sodium is a derivative of cyclic-AMP with cardiac stimulant and peripheral vasodilatory properties. It is reported to be useful in cardiac insufficiency, especially after heart surgery.

Originator

Daiichi Seiyaku; Seishin Seiyaku (Japan)

Uses

Bucladesine sodium is an analog of cyclic AMP that stimulates cAMP-dependent protein kinase. It has vasodilator properties and is used as a cardiac stimulant.

Definition

ChEBI: Bucladesine sodium is a 3',5'-cyclic purine nucleotide.

Application

N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt has been used:
as a medium supplement for neural crest stem cells (NCSCs) differentiation
as a component of thawing medium for cryopreserved human iPSC (induced pluripotent stem cell)-derived neurons
in serum-free Dulbecco′s modified eagle′s medium (DMEM) to induce astrocyte differentiation

brand name

ACTOCIN

General Description

A cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.

Biochem/physiol Actions

Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).

storage

Store at -20°C

References

1) Bartsch?et al.?(2003),?Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem.,?384?1321
2) Carranza?et al.?(1998),?Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol.,?15?511
3) Hei?et al.?(1991),?Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol.,?39?233
4) Imamura?et al.?(1998),?Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA,?95?6139
5) Xia?et al.?(2016),?Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep.,?6?20270

Bucladesine sodium Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Bucladesine sodium Suppliers

Americas 1 China 260 Europe 3 France 1 Germany 9 India 6 Japan 3 Switzerland 5 United Kingdom 11 United States 40 Global 339
Hangzhou Runyan Medical Technology Co., LTD
Tel
13989459766 18112526015
Email
sales@runyanpharma.com
Country
China
ProdList
422
Advantage
58
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19179
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8836
Advantage
52
Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3295
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
More
Less

View Lastest Price from Bucladesine sodium manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.
Product
Bucladesine sodium salt；dc2797 , sodium dibutyryl camp , dibutyryl-camp sodium salt , dbcamp 16980-89-5
Price
US $0.00-0.00/g
Min. Order
10g
Purity
90.0%Min. HPLC
Supply Ability
1000kg
Release date
2024-09-09
Hebei Yanxi Chemical Co., Ltd.
Product
Bucladesine 16980-89-5
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-14
Hebei Weibang Biotechnology Co., Ltd
Product
Bucladesine 16980-89-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-25

16980-89-5, Bucladesine sodiumRelated Search:

Adenosine 3',5'-cyclic monophosphate sodium salt NAD+ 8-CHLORO-CAMP 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT MALANTIDE N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE- HA-1004 DIHYDROCHLORIDE ARG-ARG-LYS-ALA-SER-GLY-PRO 8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Bucladesine (calciuM salt) 6-MB-CAMP SODIUM SALT 2'-O-MB-CAMP SODIUM SALT SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED Butyramide Cyclic AMP Bucladesine

  • dibutylcyclicampsodium
  • dibutylcyclicampsodiumsalt
  • dt5621sodiumsalt
  • e,butyrate(ester),monosodiumsalt
  • monosodiumdibutyrylcyclicamp
  • n-(9-beta-d-ribofuranosyl-9h-purin-6-yl)-butyramidcyclichydrogenphosphat
  • n6,02’-dibutyryladenosine3’,5’-cyclicmonophosphatesodiumsalt
  • n6,2’-o-dibutyryladenosine-3’,5’-cyclicmonophosphate(dbcamp),sodiumsalt
  • N,2'-O-Dibutanoyladenosine 3',5'-(phosphoric acid sodium) salt
  • N,2'-O-Dibutyryladenosine-3',5'-phosphoric acid sodium salt
  • Sodium bucladesine
  • ,5&Otilde
  • -cyclophosphate sodium salt monohydrate
  • N6-2&Otilde
  • -O-Dibutyryl-adenosine 3&Otilde
  • Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt
  • Calcium Dibutyacyladenosine Cyclophosphate
  • N6,2'-O-DIBUTYRYLADENOSINE 3':5'-CYCLIC MONOPHOSPHA
  • N6,2'-O-DIBUTYRYLADENOSINE-3',5'-CYCLO-P HOSPHATE SO-SALT
  • Dibutyacyladenosine
  • 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosine deriv.
  • Butyramide, N-(9-b-D-ribofuranosyl-9H-purin-6-yl)-, cyclic hydrogen phosphate butyrate (ester), monosodium salt (8CI)
  • DC 2797
  • Dibutyryl 3',5'-cyclic AMP sodium salt
  • Dibutyryl cyclic AMP monosodium salt
  • Dibutyryl cyclic AMP sodium
  • N6,2'-O-Dibutyryl-3',5'-cyclic AMP sodium salt
  • N6,2'-O-Dibutyryladenosine-3',5'-monophosphate monosodium salt
  • N6,O2'-Dibutyryl-3',5'-cyclic AMP sodium salt
  • N-6,O-2'-Dibutyryladenosine cyclic 3',5'-monophosphate sodium salt
  • Sodium N6,2'-O-dibutyryladenosine 3',5'-cyclic phosphate
  • DIBUTYRYL-CYCLICAMP
  • BUCLADESINE[N-6,O-2''-DIBUTYRYL ADENOSINE CYCLIC 3'',5''-MONOPHOSPHATE]
  • N6,2'-O-DIBUTRYL-ADENISINE-3',5'-CYCLICMONPHOSPHATE SODIUM SALT
  • Bucladesine sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt
  • Bucladesine, Dibutyryl cyclic-AMP
  • N6,2μ-O-Dibutyryladenosine 3μ,5μ-cyclic monophosphate monohydrate sodium salt
  • ibutyryl cyclic AMP sodium
  • N6,O2-DIBUTYRYLADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE NA
  • Dibutyacyladenosine cyclphosphate
  • Adenosine,N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, sodiuM salt(1:1)
  • Adenosine 3?,5?-cyclic Monophosphate, N?,O
  • Dibutyryl-cAMP sodium salt, >=98%
  • adenosine,n-(1-oxobutyl)-,cyclic3’,5’-(hydrogenphosphate)-2’-butanoate,m
  • bucladesinesodium
  • butyramide,n-(9-beta-d-ribofuranosyl-9h-purin-6-yl)-,cyclichydrogenphosphate,butyrate(ester),monosodiumsalt
  • dibutylcampsodiumsalt
  • sodiumdibutyryl3’,5’-cyclicamp
  • sodiumdibutyrylcamp
  • N6, O2-DIBUTYRYLADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE SODIUM SALT
  • N6,O2'-DIBUTYRYL ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
  • N6,O2'-DIBUTYRYLADENOSINE-3':5'-PHOSPHATE CYCLIC NA-SALT
  • N6,O2'-DIBUTYRYLADENOSINE-3',5'-PHOSPHATE CYCLIC SODIUM SALT
  • N6,2'-O-DIBUTYRYLADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
  • N6,2'-O-DIBUTYRYLADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
  • N6,2'-O-DIBUTYRYLADENOSINE-3':5'-CYCLIC MONOPHOSPHORIC ACID, SODIUM
  • ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE, N6,O2'-DIBUTYRYL-, SODIUM SALT
  • ADENOSINE-3',5'-CYCLIC MONOPHOSPHORIC ACID, N,2'O-DIBUTYRYL, SODIUM SALT