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Bucladesine sodium

Product Name
Bucladesine sodium
CAS No.
16980-89-5
Chemical Name
Bucladesine sodium
Synonyms
DC 2797;,5ÕDBcAMP-Na;N6-2ÕPrestwick_32;CAMP, DB-, NA;BUCLADESINE NA;dt5621sodiumsalt;DIB-3:5-CAMP, NA;bucladesinesodium
CBNumber
CB8236166
Molecular Formula
C18H25N5NaO8P
Formula Weight
493.39
MOL File
16980-89-5.mol
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Bucladesine sodium Property

Melting point:
>173°C (dec.)
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
white
Merck 
14,1463
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey
DBXVIQJWMFGXGO-AOTDUVMNNA-N
SMILES
O([C@@H]1[C@]2([H])OP(O)(=O)OC[C@@]2([H])O[C@H]1N1C=NC2C(=NC=NC1=2)NC(=O)CCC)C(=O)CCC.[NaH] |&1:1,2,10,13,r|
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Safety

Safety Statements 
24/25
WGK Germany 
2
RTECS 
ES5055500
F 
10-21
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
28745-M
Product name
Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem
Purity
This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging
25mg
Price
$136
Updated
2024/03/01
Sigma-Aldrich
Product number
28745-M
Product name
Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem
Purity
This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging
100mg
Price
$418
Updated
2024/03/01
Sigma-Aldrich
Product number
28745-M
Product name
Adenosine 3′,5′-cyclic Monophosphate, N⁶,O<sup>2′</sup>-Dibutyryl-, Sodium Salt
Purity
This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging
1g
Price
$1250
Updated
2024/03/01
Sigma-Aldrich
Product number
28745-M
Product name
Adenosine 3′,5′-cyclic Monophosphate, N⁶,O2′-Dibutyryl-, Sodium Salt
Purity
This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging
28745-1GM
Price
$1220
Updated
2023/06/20
TCI Chemical
Product number
D4228
Product name
N6,2'-O-Dibutyryladenosine 3',5'-Cyclic Monophosphate Sodium Salt
Purity
>97.0%(HPLC)
Packaging
25mg
Price
$121
Updated
2024/03/01
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Bucladesine sodium Chemical Properties,Usage,Production

Description

Bucladesine sodium is a derivative of cyclic-AMP with cardiac stimulant and peripheral vasodilatory properties. It is reported to be useful in cardiac insufficiency, especially after heart surgery.

Originator

Daiichi Seiyaku; Seishin Seiyaku (Japan)

Uses

Bucladesine sodium is an analog of cyclic AMP that stimulates cAMP-dependent protein kinase. It has vasodilator properties and is used as a cardiac stimulant.

Definition

ChEBI: Bucladesine sodium is a 3',5'-cyclic purine nucleotide.

Application

N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt has been used:
as a medium supplement for neural crest stem cells (NCSCs) differentiation
as a component of thawing medium for cryopreserved human iPSC (induced pluripotent stem cell)-derived neurons
in serum-free Dulbecco′s modified eagle′s medium (DMEM) to induce astrocyte differentiation

brand name

ACTOCIN

General Description

A cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.

Biochem/physiol Actions

Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).

storage

Store at -20°C

References

1) Bartsch?et al.?(2003),?Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem.,?384?1321
2) Carranza?et al.?(1998),?Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol.,?15?511
3) Hei?et al.?(1991),?Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol.,?39?233
4) Imamura?et al.?(1998),?Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA,?95?6139
5) Xia?et al.?(2016),?Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep.,?6?20270

Bucladesine sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Bucladesine sodium Suppliers

Americas 1 China 243 Europe 3 France 1 Germany 9 India 6 Japan 3 Switzerland 5 United Kingdom 11 United States 39 Global 321
Hangzhou Runyan Medical Technology Co., LTD
Tel
13989459766 18112526015
Email
sales@runyanpharma.com
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China
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TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
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J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
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Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
zhangsn@titansci.com
Country
China
ProdList
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Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17988
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XiaoGan ShenYuan ChemPharm co,ltd
Tel
0712-0712-2580635 15527768850
Email
1791901229@qq.com
Country
China
ProdList
8849
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Beijing Isomersyn Technology CO;LTD
Tel
010-82954736 13391601435
Email
sales@isomersyn.com
Country
China
ProdList
3296
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Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
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View Lastest Price from Bucladesine sodium manufacturers

Hangzhou Meiya Pharmaceutical Co Ltd
Product
Bucladesine sodium salt (DB-cAMP.Na) 16980-89-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
≥95%
Supply Ability
5000kg
Release date
2024-02-06
Hebei Duling International Trade Co. LTD
Product
Bucladesine Sodium Salt 16980-89-5
Price
US $100.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100 tons
Release date
2022-09-30
Hebei Yanxi Chemical Co., Ltd.
Product
Bucladesine 16980-89-5
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-14

16980-89-5, Bucladesine sodiumRelated Search:

Adenosine 3',5'-cyclic monophosphate sodium salt NAD+ 8-CHLORO-CAMP 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT MALANTIDE N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE- HA-1004 DIHYDROCHLORIDE ARG-ARG-LYS-ALA-SER-GLY-PRO 8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Bucladesine (calciuM salt) 6-MB-CAMP SODIUM SALT 2'-O-MB-CAMP SODIUM SALT SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED Butyramide Cyclic AMP Bucladesine

  • dibutylcyclicampsodium
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  • n6,02’-dibutyryladenosine3’,5’-cyclicmonophosphatesodiumsalt
  • n6,2’-o-dibutyryladenosine-3’,5’-cyclicmonophosphate(dbcamp),sodiumsalt
  • N,2'-O-Dibutanoyladenosine 3',5'-(phosphoric acid sodium) salt
  • N,2'-O-Dibutyryladenosine-3',5'-phosphoric acid sodium salt
  • Sodium bucladesine
  • ,5&Otilde
  • -cyclophosphate sodium salt monohydrate
  • N6-2&Otilde
  • -O-Dibutyryl-adenosine 3&Otilde
  • Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt
  • Calcium Dibutyacyladenosine Cyclophosphate
  • N6,2'-O-DIBUTYRYLADENOSINE 3':5'-CYCLIC MONOPHOSPHA
  • N6,2'-O-DIBUTYRYLADENOSINE-3',5'-CYCLO-P HOSPHATE SO-SALT
  • Dibutyacyladenosine
  • 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosine deriv.
  • Butyramide, N-(9-b-D-ribofuranosyl-9H-purin-6-yl)-, cyclic hydrogen phosphate butyrate (ester), monosodium salt (8CI)
  • DC 2797
  • Dibutyryl 3',5'-cyclic AMP sodium salt
  • Dibutyryl cyclic AMP monosodium salt
  • Dibutyryl cyclic AMP sodium
  • N6,2'-O-Dibutyryl-3',5'-cyclic AMP sodium salt
  • N6,2'-O-Dibutyryladenosine-3',5'-monophosphate monosodium salt
  • N6,O2'-Dibutyryl-3',5'-cyclic AMP sodium salt
  • N-6,O-2'-Dibutyryladenosine cyclic 3',5'-monophosphate sodium salt
  • Sodium N6,2'-O-dibutyryladenosine 3',5'-cyclic phosphate
  • DIBUTYRYL-CYCLICAMP
  • BUCLADESINE[N-6,O-2''-DIBUTYRYL ADENOSINE CYCLIC 3'',5''-MONOPHOSPHATE]
  • N6,2'-O-DIBUTRYL-ADENISINE-3',5'-CYCLICMONPHOSPHATE SODIUM SALT
  • Bucladesine sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt
  • Bucladesine, Dibutyryl cyclic-AMP
  • N6,2μ-O-Dibutyryladenosine 3μ,5μ-cyclic monophosphate monohydrate sodium salt
  • ibutyryl cyclic AMP sodium
  • N6,O2-DIBUTYRYLADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE NA
  • Dibutyacyladenosine cyclphosphate
  • Adenosine,N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, sodiuM salt(1:1)
  • Adenosine 3?,5?-cyclic Monophosphate, N?,O
  • Dibutyryl-cAMP sodium salt, >=98%
  • adenosine,n-(1-oxobutyl)-,cyclic3’,5’-(hydrogenphosphate)-2’-butanoate,m
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  • butyramide,n-(9-beta-d-ribofuranosyl-9h-purin-6-yl)-,cyclichydrogenphosphate,butyrate(ester),monosodiumsalt
  • dibutylcampsodiumsalt
  • sodiumdibutyryl3’,5’-cyclicamp
  • sodiumdibutyrylcamp
  • N6, O2-DIBUTYRYLADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE SODIUM SALT
  • N6,O2'-DIBUTYRYL ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
  • N6,O2'-DIBUTYRYLADENOSINE-3':5'-PHOSPHATE CYCLIC NA-SALT
  • N6,O2'-DIBUTYRYLADENOSINE-3',5'-PHOSPHATE CYCLIC SODIUM SALT
  • N6,2'-O-DIBUTYRYLADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
  • N6,2'-O-DIBUTYRYLADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
  • N6,2'-O-DIBUTYRYLADENOSINE-3':5'-CYCLIC MONOPHOSPHORIC ACID, SODIUM
  • ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE, N6,O2'-DIBUTYRYL-, SODIUM SALT
  • ADENOSINE-3',5'-CYCLIC MONOPHOSPHORIC ACID, N,2'O-DIBUTYRYL, SODIUM SALT