Bucladesine sodium

Product Name: Bucladesine sodium
CAS No.: 16980-89-5
Chemical Name: Bucladesine sodium
Synonyms: DC 2797;,5ÕDBcAMP-Na;N6-2ÕPrestwick_32;CAMP, DB-, NA;BUCLADESINE NA;dt5621sodiumsalt;DIB-3:5-CAMP, NA;bucladesinesodium
CBNumber: CB8236166
Molecular Formula: C18H25N5NaO8P
Formula Weight: 493.39
MOL File: 16980-89-5.mol

More

Less

Bucladesine sodium Property

Melting point:: >173°C (dec.)
storage temp.: -20°C
solubility: H₂O: 50 mg/mL
form: powder
color: white
Merck: 14,1463
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
InChIKey: DBXVIQJWMFGXGO-AOTDUVMNNA-N
SMILES: O([C@@H]1[C@]2([H])OP(O)(=O)OC[C@@]2([H])O[C@H]1N1C=NC2C(=NC=NC1=2)NC(=O)CCC)C(=O)CCC.[NaH] |&1:1,2,10,13,r|

More

Less

Safety

Safety Statements: 24/25
WGK Germany: 2
RTECS: ES5055500
F: 10-21
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 28745-M
Product name: Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem
Purity: This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging: 25mg
Price: $136
Updated: 2024/03/01

Sigma-Aldrich

Product number: 28745-M
Product name: Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem
Purity: This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging: 100mg
Price: $418
Updated: 2024/03/01

Sigma-Aldrich

Product number: 28745-M
Product name: Adenosine 3′,5′-cyclic Monophosphate, N⁶,O<sup>2′</sup>-Dibutyryl-, Sodium Salt
Purity: This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging: 1g
Price: $1250
Updated: 2024/03/01

Sigma-Aldrich

Product number: 28745-M
Product name: Adenosine 3′,5′-cyclic Monophosphate, N⁶,O2′-Dibutyryl-, Sodium Salt
Purity: This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA.
Packaging: 28745-1GM
Price: $1220
Updated: 2023/06/20

TCI Chemical

Product number: D4228
Product name: N6,2'-O-Dibutyryladenosine 3',5'-Cyclic Monophosphate Sodium Salt
Purity: >97.0%(HPLC)
Packaging: 25mg
Price: $121
Updated: 2024/03/01

More

Less

Bucladesine sodium Chemical Properties,Usage,Production

Description

Bucladesine sodium is a derivative of cyclic-AMP with cardiac stimulant and peripheral vasodilatory properties. It is reported to be useful in cardiac insufficiency, especially after heart surgery.

Originator

Daiichi Seiyaku; Seishin Seiyaku (Japan)

Uses

Bucladesine sodium is an analog of cyclic AMP that stimulates cAMP-dependent protein kinase. It has vasodilator properties and is used as a cardiac stimulant.

Definition

ChEBI: Bucladesine sodium is a 3',5'-cyclic purine nucleotide.

Application

N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt has been used:
as a medium supplement for neural crest stem cells (NCSCs) differentiation
as a component of thawing medium for cryopreserved human iPSC (induced pluripotent stem cell)-derived neurons
in serum-free Dulbecco′s modified eagle′s medium (DMEM) to induce astrocyte differentiation

brand name

ACTOCIN

General Description

A cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.

Biochem/physiol Actions

Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).

storage

Store at -20°C

References

1) Bartsch?et al.?(2003),?Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem.,?384?1321
2) Carranza?et al.?(1998),?Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol.,?15?511
3) Hei?et al.?(1991),?Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol.,?39?233
4) Imamura?et al.?(1998),?Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA,?95?6139
5) Xia?et al.?(2016),?Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep.,?6?20270

Bucladesine sodium Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Bucladesine sodium Suppliers

Americas 1 China 258 Europe 3 France 1 Germany 9 India 6 Japan 3 Switzerland 5 United Kingdom 11 United States 40 Global 337

Sinus Biochemistry & Electrophoresis GmbH

Tel: --
Fax: --
Email: m.demharter@sinus-biochem.de
Country: Germany
ProdList: 621
Advantage: 68

Pharma Waldhof Gmbh

Tel: --
Fax: --
Email: info@pharmawaldhof.de
Country: Germany
ProdList: 67
Advantage: 58

SERVA Electrophoresis GmbH

Tel: --
Fax: --
Email: info@serva.de
Country: Germany
ProdList: 1142
Advantage: 80

CHEMOS GmbH & Co. KG

Tel: --
Fax: --
Email: chemos@chemos.de
Country: Germany
ProdList: 6727
Advantage: 58

Biolog Life Science Institute

Tel: --
Fax: --
Email: service@biolog.de
Country: Germany
ProdList: 275
Advantage: 74

Service Chemical Inc.

Tel: --
Fax: --
Email: sales@chemos-group.com
Country: Germany
ProdList: 6350
Advantage: 71

Biomol Feinchemikalien GmbH

Tel: --
Fax: --
Email: info@biomol.de
Country: Germany
ProdList: 479
Advantage: 74

BIOTREND Chemicals AG

Tel: --
Fax: --
Email: info@biotrend.ch
Country: Germany
ProdList: 1250
Advantage: 62

Pharma-Waldhof GmbH

Tel: --
Fax: --
Country: Germany
ProdList: 184
Advantage: 52

More

Less

View Lastest Price from Bucladesine sodium manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: Bucladesine sodium salt；dc2797 , sodium dibutyryl camp , dibutyryl-camp sodium salt , dbcamp 16980-89-5
Price: US $0.00-0.00/g
Min. Order: 10g
Purity: 90.0%Min. HPLC
Supply Ability: 1000kg
Release date: 2024-09-09

Hebei Yanxi Chemical Co., Ltd.

Product: Bucladesine 16980-89-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-11-14

Hebei Weibang Biotechnology Co., Ltd

Product: Bucladesine 16980-89-5
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

16980-89-5, Bucladesine sodiumRelated Search:

Adenosine 3',5'-cyclic monophosphate sodium salt NAD+ 8-CHLORO-CAMP 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT MALANTIDE N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE- HA-1004 DIHYDROCHLORIDE ARG-ARG-LYS-ALA-SER-GLY-PRO 8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Bucladesine (calciuM salt) 6-MB-CAMP SODIUM SALT 2'-O-MB-CAMP SODIUM SALT SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED Butyramide Cyclic AMP Bucladesine

dibutylcyclicampsodium

dibutylcyclicampsodiumsalt

dt5621sodiumsalt

e,butyrate(ester),monosodiumsalt

monosodiumdibutyrylcyclicamp

n-(9-beta-d-ribofuranosyl-9h-purin-6-yl)-butyramidcyclichydrogenphosphat

n6,02’-dibutyryladenosine3’,5’-cyclicmonophosphatesodiumsalt

n6,2’-o-dibutyryladenosine-3’,5’-cyclicmonophosphate(dbcamp),sodiumsalt

N,2'-O-Dibutanoyladenosine 3',5'-(phosphoric acid sodium) salt

N,2'-O-Dibutyryladenosine-3',5'-phosphoric acid sodium salt

Sodium bucladesine

,5&Otilde

-cyclophosphate sodium salt monohydrate

N6-2&Otilde

-O-Dibutyryl-adenosine 3&Otilde

Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, monosodium salt

Calcium Dibutyacyladenosine Cyclophosphate

N6,2'-O-DIBUTYRYLADENOSINE 3':5'-CYCLIC MONOPHOSPHA

N6,2'-O-DIBUTYRYLADENOSINE-3',5'-CYCLO-P HOSPHATE SO-SALT

Dibutyacyladenosine

4H-Furo[3,2-d]-1,3,2-dioxaphosphorin, adenosine deriv.

Butyramide, N-(9-b-D-ribofuranosyl-9H-purin-6-yl)-, cyclic hydrogen phosphate butyrate (ester), monosodium salt (8CI)

DC 2797

Dibutyryl 3',5'-cyclic AMP sodium salt

Dibutyryl cyclic AMP monosodium salt

Dibutyryl cyclic AMP sodium

N6,2'-O-Dibutyryl-3',5'-cyclic AMP sodium salt

N6,2'-O-Dibutyryladenosine-3',5'-monophosphate monosodium salt

N6,O2'-Dibutyryl-3',5'-cyclic AMP sodium salt

N-6,O-2'-Dibutyryladenosine cyclic 3',5'-monophosphate sodium salt

Sodium N6,2'-O-dibutyryladenosine 3',5'-cyclic phosphate

DIBUTYRYL-CYCLICAMP

BUCLADESINE[N-6,O-2''-DIBUTYRYL ADENOSINE CYCLIC 3'',5''-MONOPHOSPHATE]

N6,2'-O-DIBUTRYL-ADENISINE-3',5'-CYCLICMONPHOSPHATE SODIUM SALT

Bucladesine sodium salt, Dibutyryl cAMP sodium salt, Dibutyryl cyclic-AMP sodium salt

Bucladesine, Dibutyryl cyclic-AMP

N6,2μ-O-Dibutyryladenosine 3μ,5μ-cyclic monophosphate monohydrate sodium salt

ibutyryl cyclic AMP sodium

N6,O2-DIBUTYRYLADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE NA

Dibutyacyladenosine cyclphosphate

Adenosine,N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate, sodiuM salt(1:1)

Adenosine 3?,5?-cyclic Monophosphate, N?,O

Dibutyryl-cAMP sodium salt, >=98%

adenosine,n-(1-oxobutyl)-,cyclic3’,5’-(hydrogenphosphate)-2’-butanoate,m

bucladesinesodium

butyramide,n-(9-beta-d-ribofuranosyl-9h-purin-6-yl)-,cyclichydrogenphosphate,butyrate(ester),monosodiumsalt

dibutylcampsodiumsalt

sodiumdibutyryl3’,5’-cyclicamp

sodiumdibutyrylcamp

N6, O2-DIBUTYRYLADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE SODIUM SALT

N6,O2'-DIBUTYRYL ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

N6,O2'-DIBUTYRYLADENOSINE-3':5'-PHOSPHATE CYCLIC NA-SALT

N6,O2'-DIBUTYRYLADENOSINE-3',5'-PHOSPHATE CYCLIC SODIUM SALT

N6,2'-O-DIBUTYRYLADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT

N6,2'-O-DIBUTYRYLADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT

N6,2'-O-DIBUTYRYLADENOSINE-3':5'-CYCLIC MONOPHOSPHORIC ACID, SODIUM

ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE, N6,O2'-DIBUTYRYL-, SODIUM SALT

ADENOSINE-3',5'-CYCLIC MONOPHOSPHORIC ACID, N,2'O-DIBUTYRYL, SODIUM SALT