8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

Product Name: 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
CAS No.: 129735-00-8
Chemical Name: 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
Synonyms: RP-8-BR-CAMPS;RP-8-BR-CAMPS, NA;8-BR-CAMPS NA, RP-ISOMER;RP-8-BR-CAMPS SODIUM SALT;8-BROMOADENOSINE-3',5'-CYCLIC * MONOPHOSPHOROTHIOAT;8-Bromoadenosine-3'',5''-cyclic monophosphothioate Rp isomer;Adenosine, 8-bromo-, cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate];8-BROMOADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP-ISOMER SODIUM SALT;8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT, RPISOMER;8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT
CBNumber: CB0266088
Molecular Formula: C10H11BrN5O5PS
Formula Weight: 424.17
MOL File: 129735-00-8.mol

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8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Property

Boiling point:: 690.3±65.0 °C(Predicted)
Density: 2.70±0.1 g/cm3(Predicted)
storage temp.: −20°C
form: solid
pka: -0.60±0.60(Predicted)
Water Solubility: water: 40mg/mL

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 116816
Product name: Adenosine 3′,5′-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt
Purity: A potent, cell-permeable, and reversible metabolically-stable cAMP antagonist that inhibits cAMP-dependent protein kinase and shows preference for PKA type I.
Packaging: 5μMOL
Price: $812
Updated: 2025/07/31

Biosynth Carbosynth

Product number: NB13568
Product name: 8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Rp-isomer sodium salt
Packaging: 5mg
Price: $900
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB13568
Product name: 8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Rp-isomer sodium salt
Packaging: 250ug
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB13568
Product name: 8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Rp-isomer sodium salt
Packaging: 500ug
Price: $135
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB13568
Product name: 8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Rp-isomer sodium salt
Packaging: 1mg
Price: $250
Updated: 2021/12/16

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8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Chemical Properties,Usage,Production

Uses

Rp-8-Br-cAMPS is an analog of cAMP and an inhibitor of PKA. Rp-8-Br-cAMPS occupies cAMP binding sites on PKA type I regulatory subunits, thereby preventing PKA dissociation and activation. Rp-8-Br-cAMPS can be used in the study of tumors and retrovirus-induced immune deficiency. Rp-8-Br-cAMPS also inhibits insulin secretion[1][2][3].

Biological Activity

Cell permeable: yes', 'Primary Target
PKA 1', 'Product does not compete with ATP.', 'Reversible: yes

in vivo

Rp-8-Br-cAMPS (1 mg; intraperitoneal injection; 10 days) improves immune function in a mouse retrovirus infection model^[3].

Animal Model:	Murine leukemia retrovirus RadLV-Rs treated male C57BL/6 mice^[3]
Dosage:	1 mg
Administration:	Intraperitoneal injection (i.p.); 10 days
Result:	Had no significant effect on the extent of lymphadenopathy and splenomegaly which is typical of RadLV-Rs retroviral infection. Strongly increased responses to the anti-CD3 mAb. Improved T cell responses.

References

[1] Raskovalova T, et al. Adenosine-mediated inhibition of cytotoxic activity and cytokine production by IL-2/NKp46-activated NK cells: involvement of protein kinase A isozyme I (PKA I). Immunol Res. 2006;36(1-3):91-9. DOI:10.1385/IR:36:1:91
[2] Yang S, et al. Enhanced cAMP protein kinase A signaling determines improved insulin secretion in a clonal insulin-producing beta-cell line (INS-1 832/13). Mol Endocrinol. 2004 Sep;18(9):2312-20. DOI:10.1210/me.2004-0148
[3] Nayjib B, et al. In vivo administration of a PKA type I inhibitor (Rp-8-Br-cAMPS) restores T-cell responses in retrovirus-infected mice[J]. The Open Immunology Journal, 2008, 1(1).

8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT Suppliers

China 6 Germany 1 Japan 2 Switzerland 2 United Kingdom 3 United States 5 Global 19

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129735-00-8, 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALTRelated Search:

A-3 HYDROCHLORIDE 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT MALANTIDE N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE- HA-1004 DIHYDROCHLORIDE ARG-ARG-LYS-ALA-SER-GLY-PRO 8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Adenosine 3',5'-cyclic monophosphate sodium salt 8-CHLORO-CAMP PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE 8-BROMO-2'-DEOXYADENOSINE SODIUM O,O-DIETHYLTHIOPHOSPHATE 8-BROMOADENOSINE ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT sodium O,O-dimethyl thiophosphate 8-BROMO-2'-O-MONOBUTYRYLADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

8-BROMOADENOSINE-3',5'-CYCLIC * MONOPHOSPHOROTHIOAT

8-Bromoadenosine-3'',5''-cyclic monophosphothioate Rp isomer

RP-8-BR-CAMPS

RP-8-BR-CAMPS, NA

RP-8-BR-CAMPS SODIUM SALT

8-bromoadenosine-3’,5’-cyclicmonophosphorothioate,rp-isomer(rp-8-br-camps),sodiumsalt

8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT

8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE SODIUM SALT, RPISOMER

8-BROMOADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, RP-ISOMER SODIUM SALT

8-BR-CAMPS NA, RP-ISOMER

ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, 8-BROMO-, RP-ISOMER, SODIUM SALT

Adenosine, 8-bromo-, cyclic 3',5'-[hydrogen [P(R)]-phosphorothioate]

8-Bromoadenosine 3',5'-cyclic monophosphorothioate, Rp-isomer sodium salt

129735-00-8

C10H10BrN5O5PSNa

C10H11BrN5O5PSNa

G Proteins and Cyclic Nucleotides

Cyclic Nucleotides and Analogs

Cyclic Nucleotide Metabolism

Cell Signaling and Neuroscience

Cell Biology

BioChemical