SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE

Product Name: SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE
CAS No.: 73208-40-9
Chemical Name: SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE
Synonyms: SP-CAMPS TEA;(R)-Adenosine;CAMPS TEA, SP-ISOMER;cAMPS-Rp, triethylam;SP-CAMPS TRIETHYLAMINE;RP-CAMPS TRIETHYLAMINE;SP-CAMPS TRIETHYL AMMONIUM SALT;CAMPS-SP, TRIETHYLAMMONIUM SALT;Cyclic3',5'-(hydrogenphosphorothioate)triethylammonium;SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE
CBNumber: CB5699120
Molecular Formula: C16H27N6O5PS
Formula Weight: 446.46
MOL File: 73208-40-9.mol

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SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE Property

storage temp.: −20°C
solubility: H₂O: soluble
form: solid
color: white

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Safety

Safety Statements: 22-24/25
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B9003
Product name: cAMPS-Sp,triethylammoniumsalt
Packaging: 1mg
Price: $234
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NA58197
Product name: Adenosine 3',5'-cyclic monophosphothioate Rp-isomer sodium salt
Packaging: 1mg
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NA58197
Product name: Adenosine 3',5'-cyclic monophosphothioate Rp-isomer sodium salt
Packaging: 2mg
Price: $390
Updated: 2021/12/16

ChemScene

Product number: CS-0019676
Product name: Rp-cAMPS
Packaging: 5mg
Price: $500
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0002727
Product name: RP-ADENOSINE-3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE
Purity: 95.00%
Packaging: 1MG
Price: $698.78
Updated: 2021/12/16

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SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE Chemical Properties,Usage,Production

Uses

Rp-cAMPS, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6].

Biological Activity

Cell-permeable cAMP analog; acts as a competitive antagonist of cAMP-induced activation of PKA (IC 50 = 11-16 μ M) by interacting with cAMP binding sites on the regulatory subunits. Resistant to hydrolysis by phosphodiesterases. Also available as part of the PKA Tocriset™ .

in vivo

Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons^[2].

References

[1] R J de Wit, et al. Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases. Eur J Biochem. 1984 Jul 16;142(2):255-60. DOI:10.1111/j.1432-1033.1984.tb08279.x
[2] Rothermel JD, et al. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3',5'-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem J. 1988 May 1;251(3):757-62. DOI:10.1042/bj2510757
[3] Fu Y, et al. PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol Pain. 2008 Jul 16;4:26. DOI:10.1186/1744-8069-4-26
[4] Kuriyama S, et al. Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest Ophthalmol Vis Sci. 1995 Mar;36(3):730-6. PMID:7890503
[5] Dostmann WR, et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91. PMID:2162349
[6] Van Haastert PJ, et al. Competitive cAMP antagonists for cAMP-receptor proteins. J Biol Chem. 1984 Aug 25;259(16):10020-4. PMID:6088478

SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE Suppliers

China 13 Germany 3 Switzerland 2 United Kingdom 3 United States 11 Global 32

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
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EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
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NewCan Biotech Limited

Tel: +86-0571-86912261 +8613735419629
Email: sales@newcanbio.com
Country: China
ProdList: 9985
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
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BOC Sciences

Tel: 16314854226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 9713
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BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
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MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
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Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
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73208-40-9, SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINERelated Search:

8-CHLORO-CAMP KEMPTIDE PKA Inhibitor Fragment (6-22) amide ADENOSINE 3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER, TRIETHYLAMMONIUM SALT KT5720 A-3 HYDROCHLORIDE 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT MALANTIDE N-(2-(METHYLAMINO)ETHYL)ISOQUINOLINE- HA-1004 DIHYDROCHLORIDE ARG-ARG-LYS-ALA-SER-GLY-PRO 8-(4-CHLOROPHENYLTHIO)-ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT Adenosine 3',5'-cyclic monophosphate sodium salt 8-BROMOADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT PROTEIN KINASE A INHIBITOR 14-22 AMIDE, CELL-PERMEABLE, MYRISTOYLATED ADENOSINE-3',5'-CYCLIC -MONOPHOSPHOROTHIOATE SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE

ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE, SP-ISOMER TRIETHYLAMMONIUM SALT

ADENOSINE 3',5'-CYCLIC PHOSPHOROTHIOATE-SP, TRIETHYLAMMONIUM SALT

(R)-Adenosine

Cyclic3',5'-(hydrogenphosphorothioate)triethylammonium

(R)-Adenosine,cyclic3',5'-(hydrogenphosphorothioate)triethylammonium

Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt

adenosine-3’,5’-cyclicmonophosphorothioate,rp-isomer(rp-camps),sodiumsalt

SP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE

SP-CYCLIC 3',5'-HYDROGEN PHOSPHOROTHIOATE ADENOSINE TRIETHYLAMINE

SP-CAMPS TEA

SP-CAMPS TRIETHYLAMINE

SP-CAMPS TRIETHYL AMMONIUM SALT

(S)-ADENOSINE, CYCLIC 3',5'-(HYDROGENPHOSPHOROTHIOATE) TRIETHYLAMMONIUM SALT

RP-ADENOSINE 3',5'-CYCLIC MONOPHOSPHOTHIOATE TRIETHYLAMINE

RP-CAMPS TRIETHYLAMINE

Adenosine-3'',5''-cyclic monophosphothioate sodium salt Rp isomer

CAMPS TEA, SP-ISOMER

CAMPS-SP, TRIETHYLAMMONIUM SALT

ADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, SP-ISOMER TRIETHYL AMMONIUM SALT

cAMPS-Rp, triethylam

Adenosine 3',5'-cyclic monophosphothioate Rp-isomer sodium salt

73208-40-9

C10H12N5O5PSC6H15N

BioChemical

Cell Signaling and Neuroscience

Cell Biology

G Proteins and Cyclic Nucleotides

Cyclic Nucleotide Metabolism

Cyclic Nucleotides and Analogs

Cyclic Nucleotide related