KT5720
- Product Name
- KT5720
- CAS No.
- 108068-98-0
- Chemical Name
- KT5720
- Synonyms
- KT5720;Aids004395;Aids-004395;KT-5720 (KT5720);InSolution? KT5720;Antibiotic KT 5720;PROTEIN KINASE INHIBITOR KT 5720;KT5720 Antibiotic KT 5720;KT5720 - CAS 108068-98-0 - Calbiochem;InSolution KT5720 - CAS 108068-98-0 - Calbiochem
- CBNumber
- CB6665746
- Molecular Formula
- C32H31N3O5
- Formula Weight
- 537.61
- MOL File
- 108068-98-0.mol
KT5720 Property
- Boiling point:
- 715.0±60.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- methanol: 5 mg/mL
- form
- powder
- pka
- 11.96±0.40(Predicted)
- color
- white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- K3761
- Product name
- KT 5720
- Purity
- ≥98% (HPLC), powder
- Packaging
- 0.1mg
- Price
- $259
- Updated
- 2024/03/01
- Product number
- 420320
- Product name
- KT5720 - CAS 108068-98-0 - Calbiochem
- Purity
- A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a.
- Packaging
- 50μG
- Price
- $144
- Updated
- 2024/03/01
- Product number
- 420323
- Product name
- InSolution KT5720 - CAS 108068-98-0 - Calbiochem
- Packaging
- 50μg
- Price
- $159
- Updated
- 2024/03/01
- Product number
- 420320
- Product name
- KT5720 - CAS 108068-98-0 - Calbiochem
- Purity
- A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a.
- Packaging
- 100μG
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 10011011
- Product name
- KT 5720
- Purity
- ≥98%
- Packaging
- 50μg
- Price
- $81
- Updated
- 2024/03/01
KT5720 Chemical Properties,Usage,Production
Description
Protein kinase A (PKA) regulates multiple signal transduction events via protein phosphorylation and is integral to all cellular responses involving the cyclic AMP second messenger system. KT 5720 is one of a family of compounds synthesized by the fungus Nocardiopsis sp. It blocks PKA signaling through competitive inhibition of ATP with a Ki value of 60 nM. Reported IC50 values vary widely depending upon ATP concentration tested and can range from 56 nM (low ATP) to 3 μM (physiologic ATP). Non-
Chemical Properties
White solid
Uses
KT 5720 is a potent, specific and cell-permeable inhibitor of PKA.
Definition
ChEBI: An organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of hexyl (3S)-3-hydroxy-2-methyltetrahydrofuran-3- arboxylate (the 2R,3S,5S product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1,5-dihydro-2H-pyrrol- -one.
Biological Activity
Potent, selective inhibitor of protein kinase A (K i = 60 nM). Has no effect on PKG or PKC (K i > 2 μ M). Reversibly arrests human skin fibroblasts in the G 1 phase. Also available as part of the Mixed Kinase Inhibitor Tocriset™ and PKA Tocriset™ .
Biochem/physiol Actions
Cell permeable: yes
storage
-20°C (desiccate)
References
1) Kase et al. (1987), K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436 2) Cabell et al. (1993), Effects of selective inhibition of protein kinase C, cyclic AMP-dependent protein kinase, and Ca(2+)-calmodulin-dependent protein kinase on neurite development in cultured rat hippocampal neurons; Int. J. Dev. Neurosci., 11 357
KT5720 Preparation Products And Raw materials
Raw materials
Preparation Products
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