1-ethyl-1H-indole-4-carbaldehyde
- Product Name
- 1-ethyl-1H-indole-4-carbaldehyde
- CAS No.
- 894852-86-9
- Chemical Name
- 1-ethyl-1H-indole-4-carbaldehyde
- Synonyms
- Albb-004947;1-ethyl-1H-indole-4-carbaldehyde;1H-Indole-4-carboxaldehyde, 1-ethyl-;1-ethyl-1H-indole-4-carbaldehyde(SALTDATA: FREE)
- CBNumber
- CB62132392
- Molecular Formula
- C11H11NO
- Formula Weight
- 173.21
- MOL File
- 894852-86-9.mol
1-ethyl-1H-indole-4-carbaldehyde Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E902738
- Product name
- 1-ethyl-1H-indole-4-carbaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- E902738
- Product name
- 1-ethyl-1H-indole-4-carbaldehyde
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- CHM0080264
- Product name
- 1-ETHYL-1H-INDOLE-4-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 0.5G
- Price
- $682
- Updated
- 2021/12/16
- Product number
- CHM0080264
- Product name
- 1-ETHYL-1H-INDOLE-4-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $750.75
- Updated
- 2021/12/16
- Product number
- CHM0080264
- Product name
- 1-ETHYL-1H-INDOLE-4-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1328.25
- Updated
- 2021/12/16
1-ethyl-1H-indole-4-carbaldehyde Chemical Properties,Usage,Production
Synthesis
1074-86-8
75-03-6
894852-86-9
a) Synthesis of 1-ethyl-1H-indole-4-carboxaldehyde: Sodium hydride (827 mg, 60% dispersion in oil, 20.7 mmol) was added batchwise to an anhydrous N,N-dimethylformamide (DMF, 6.5 mL) solution of 1H-indole-4-carboxaldehyde (2.00 g, 13.8 mmol) under argon protection. The reaction mixture was stirred at room temperature for 30 min. Subsequently, ethidium iodide (2.22 mL, 27.5 mmol) was slowly added dropwise and stirring was continued for 12 hours at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of water (100 mL) and extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, washed with saturated saline (100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give an orange oily crude product. Purification by silica gel column chromatography (elution gradient: dichloromethane to 5% methanol/dichloromethane) afforded the target compound 1-ethyl-1H-indole-4-carbaldehyde (2.43 g, 99% yield) as a yellow oil. Its nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, DMSO-d6) data were as follows: δ 10.19 (s, 1H), 7.88 (d, J = 8.1 Hz, 1H), 7.68-7.64 (m, 2H), 7.37-7.32 (m, 1H), 7.08 (d, J = 3.0 Hz, 1H), 4.28 (q, J = 7.2 Hz, 2H), 1.36 (t, J = 7.2 Hz, 3H).
References
[1] Patent: WO2007/53131, 2007, A2. Location in patent: Page/Page column 179-180
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 7, p. 2060 - 2079
1-ethyl-1H-indole-4-carbaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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