ANTIBIOTIC UCN-02
- Product Name
- ANTIBIOTIC UCN-02
- CAS No.
- 121569-61-7
- Chemical Name
- ANTIBIOTIC UCN-02
- Synonyms
- UCN-02;UCN02,UCN 02;ANTIBIOTIC UCN-02;9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-, (3S,9S,10R,11R,13R)-
- CBNumber
- CB42446750
- Molecular Formula
- C28H26N4O4
- Formula Weight
- 482.53
- MOL File
- 121569-61-7.mol
ANTIBIOTIC UCN-02 Property
- Boiling point:
- 705.7±60.0 °C(Predicted)
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- solution in ethanol.
- pka
- 12.25±0.70(Predicted)
N-Bromosuccinimide Price
- Product number
- 20221
- Product name
- UCN-02
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $299
- Updated
- 2024/03/01
- Product number
- 20221
- Product name
- UCN-02
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $1121
- Updated
- 2024/03/01
- Product number
- A2297-39A
- Product name
- Antibiotic UCN-02
- Packaging
- 1mg
- Price
- $523
- Updated
- 2021/12/16
- Product number
- C4829
- Product name
- UCN-02
- Packaging
- 1mg(solution)
- Price
- $408
- Updated
- 2021/12/16
- Product number
- KIN0002440
- Product name
- UCN-02
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.88
- Updated
- 2021/12/16
ANTIBIOTIC UCN-02 Chemical Properties,Usage,Production
Description
UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01 first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. UCN-02 inhibits protein kinase C with a slightly reduced potency than UCN-01 (IC50 = 62 and 4.1 nM, for UNC-02 and UCN-01, respectively) and is cytotoxic to the growth of HeLa S3 cells.
Uses
UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.
Uses
UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing?Streptomyces?culture. Related analogs of staurosporine which is non-specific protein kinase inhibitor.
References
[1] takahashi, i. ,saitoh, y.,yoshida, m., et al. ucn-01 and ucn-02, new selective inhibitors of protein kinase c. ii. purification, physico-chemical properties, structural determination and biological activities. j.antibiot.(tokyo) 42(4), 571-576 (1989).
[2] newton a c. protein kinase c: structure, function, and regulation[j]. journal of biological chemistry, 1995, 270(48): 28495-28498.
ANTIBIOTIC UCN-02 Preparation Products And Raw materials
Raw materials
Preparation Products
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