1H-INDOLE-5-CARBOXAMIDE, 97%

Product Name: 1H-INDOLE-5-CARBOXAMIDE, 97%
CAS No.: 1670-87-7
Chemical Name: 1H-INDOLE-5-CARBOXAMIDE, 97%
Synonyms: SD-169;5-CarbaMoylindole;5-(AMinocarbonyl)-1H-indole;1H-Indole-5-carboxamide(9CI);1H-INDOLE-5-CARBOXAMIDE, 97%;1H-indole-5-carboxamide(SD-169);Indole-5-carboxamide (7CI, 8CI);p38 MAP Kinase Inhibitor VII, SD-169;p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem;5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole
CBNumber: CB0972248
Molecular Formula: C9H8N2O
Formula Weight: 160.17
MOL File: 1670-87-7.mol

More

Less

1H-INDOLE-5-CARBOXAMIDE, 97% Property

Melting point:: 159-163 °C
Boiling point:: 457.6±18.0 °C(Predicted)
Density: 1.328±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Off-white solid
pka: 16.25±0.30(Predicted)
color: Off-White to Light Purple

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 506158
Product name: p38 MAP Kinase Inhibitor VII, SD-169
Packaging: 10mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 14156
Product name: SD 169
Purity: ≥97%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 14156
Product name: SD 169
Purity: ≥97%
Packaging: 10mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 14156
Product name: SD 169
Purity: ≥97%
Packaging: 25mg
Price: $142
Updated: 2024/03/01

TRC

Product number: I615500
Product name: 1H-Indole-5-carboxamide
Packaging: 10g
Price: $950
Updated: 2021/12/16

More

Less

1H-INDOLE-5-CARBOXAMIDE, 97% Chemical Properties,Usage,Production

Uses

SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM). It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM. SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg. In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis. SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.

Uses

1H-Indole-5-carboxamide (SD-169) is a p38α MAPK-selective inhibitor. 1H-Indole-5-carboxamide (SD-169) prevents the development and progression of diabetes in nonobese diabetic (NOD) mice by inhibiting T cell infiltration and activation.

Definition

ChEBI: 1H-indole-5-carboxamide is an indolecarboxamide.

Biological Activity

Selective, orally active, ATP-competitive inhibitor of p38 α MAPK (IC 50 values are 3.2, 122 and > 50000 nM for p38 α , p38 β and p38 γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.

References

[1] medicherla s, protter a a, ma j y, et al. preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes[j]. journal of pharmacology and experimental therapeutics, 2006, 318(1): 99-107.
[2] myers r r, sekiguchi y, kikuchi s, et al. inhibition of p38 map kinase activity enhances axonal regeneration[j]. experimental neurology, 2003, 184(2): 606-614.

1H-INDOLE-5-CARBOXAMIDE, 97% Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1H-INDOLE-5-CARBOXAMIDE, 97% Suppliers

Canada 1 China 73 Europe 1 Germany 1 India 2 Switzerland 1 The Netherlands 1 United Kingdom 2 United States 22 USA 1 Global 105

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Carbott PharmTech Inc.

Tel: 0535-6385396
Fax: +86 (535) 638-9971
Email: info@carbottpharm.com
Country: China
ProdList: 917
Advantage: 56

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
Email: sales@vdmbio.com
Country: United States
ProdList: 510
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 1995
Advantage: 58

SYN|thesis med chem P/L

Tel: +86-021-50720296
Fax: +86-021-50720297
Email: service@synkinase.com
Country: China
ProdList: 266
Advantage: 58

Weifang Yuda Pharmaceutical Technology Co., Ltd.

Tel: 17663603912
Fax: +86-536- 8637276
Email: 2710256076@qq.com
Country: China
ProdList: 200
Advantage: 56

More

Less

View Lastest Price from 1H-INDOLE-5-CARBOXAMIDE, 97% manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1H-INDOLE-5-CARBOXAMIDE, 97% 1670-87-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1H-INDOLE-5-CARBOXAMIDE 1670-87-7
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

Nanjing jinheyou Trading Co., Ltd.

Product: 1H-INDOLE-5-CARBOXAMIDE, 97% 1670-87-7
Price: US $0.00/g
Min. Order: 1g
Purity: 95%min
Supply Ability: 20kg/month
Release date: 2019-12-20

1670-87-7, 1H-INDOLE-5-CARBOXAMIDE, 97%Related Search:

3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole SD-208 FROVATRIPTAN GO 6976 K-252A 4'-demethylamino-4'-hydroxystaurosporine STAUROSPORINE ANTIBIOTIC UCN-02 1-BENZYL-2,3-DIMETHYL-1H-INDOLE-5-CARBOHYDRAZIDE 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE K-252C N-ethoxycarbonyl-7-oxostaurosporine 5-CARBOXAMIDOTRYPTAMINE, [1,2-3H]- 5-CARBOXAMIDO[3H]TRYPTAMINE, TRIFLUOROACETATE 5-carboxamidotryptamine maleate salt 2,3-DIMETHYL-1 H-INDOLE-5-CARBOXYLIC ACID HYDRAZIDE TAN 999 N,N-DIPROPYL-5-CARBOXAMIDOTRYPTAMINE MALEATE

1H-INDOLE-5-CARBOXAMIDE, 97%

SD-169

1H-Indole-5-carboxamide(9CI)

5-(AMinocarbonyl)-1H-indole

5-CarbaMoylindole

p38 MAP Kinase Inhibitor VII, SD-169

5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole

p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem

Indole-5-carboxamide (7CI, 8CI)

HSPs,p38α,kinases,SD-169,protein,inhibit,Inhibitor,p38 MAPK,MAPK,SD169,heat,diabete,mitogen-activated,proteins,shock

1H-indole-5-carboxamide(SD-169)

1670-87-7

AMIDE

Heterocyclic Compounds