1H-INDOLE-5-CARBOXAMIDE, 97%

ChemicalBook > CAS DataBase List > 1H-INDOLE-5-CARBOXAMIDE, 97%

1H-INDOLE-5-CARBOXAMIDE, 97%

Product Name: 1H-INDOLE-5-CARBOXAMIDE, 97%
CAS No.: 1670-87-7
Chemical Name: 1H-INDOLE-5-CARBOXAMIDE, 97%
Synonyms: SD-169;5-CarbaMoylindole;5-(AMinocarbonyl)-1H-indole;1H-Indole-5-carboxamide(9CI);1H-INDOLE-5-CARBOXAMIDE, 97%;1H-indole-5-carboxamide(SD-169);Indole-5-carboxamide (7CI, 8CI);p38 MAP Kinase Inhibitor VII, SD-169;p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem;5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole
CBNumber: CB0972248
Molecular Formula: C9H8N2O
Formula Weight: 160.17
MOL File: 1670-87-7.mol

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1H-INDOLE-5-CARBOXAMIDE, 97% Property

Melting point:: 159-163 °C
Boiling point:: 457.6±18.0 °C(Predicted)
Density: 1.328±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Off-white solid
pka: 16.25±0.30(Predicted)
color: Off-White to Light Purple

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 506158
Product name: p38 MAP Kinase Inhibitor VII, SD-169
Packaging: 10mg
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 14156
Product name: SD 169
Purity: ≥97%
Packaging: 5mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 14156
Product name: SD 169
Purity: ≥97%
Packaging: 10mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 14156
Product name: SD 169
Purity: ≥97%
Packaging: 25mg
Price: $142
Updated: 2024/03/01

TRC

Product number: I615500
Product name: 1H-Indole-5-carboxamide
Packaging: 10g
Price: $950
Updated: 2021/12/16

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1H-INDOLE-5-CARBOXAMIDE, 97% Chemical Properties,Usage,Production

Uses

SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM). It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM. SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg. In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis. SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.

Uses

1H-Indole-5-carboxamide (SD-169) is a p38α MAPK-selective inhibitor. 1H-Indole-5-carboxamide (SD-169) prevents the development and progression of diabetes in nonobese diabetic (NOD) mice by inhibiting T cell infiltration and activation.

Definition

ChEBI: 1H-indole-5-carboxamide is an indolecarboxamide.

Biological Activity

Selective, orally active, ATP-competitive inhibitor of p38 α MAPK (IC 50 values are 3.2, 122 and > 50000 nM for p38 α , p38 β and p38 γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.

References

[1] medicherla s, protter a a, ma j y, et al. preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes[j]. journal of pharmacology and experimental therapeutics, 2006, 318(1): 99-107.
[2] myers r r, sekiguchi y, kikuchi s, et al. inhibition of p38 map kinase activity enhances axonal regeneration[j]. experimental neurology, 2003, 184(2): 606-614.

1H-INDOLE-5-CARBOXAMIDE, 97% Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-INDOLE-5-CARBOXAMIDE, 97% Suppliers

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View Lastest Price from 1H-INDOLE-5-CARBOXAMIDE, 97% manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1H-INDOLE-5-CARBOXAMIDE, 97% 1670-87-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1H-INDOLE-5-CARBOXAMIDE 1670-87-7
Price: US $1.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

Nanjing jinheyou Trading Co., Ltd.

Product: 1H-INDOLE-5-CARBOXAMIDE, 97% 1670-87-7
Price: US $0.00/g
Min. Order: 1g
Purity: 95%min
Supply Ability: 20kg/month
Release date: 2019-12-20

1670-87-7, 1H-INDOLE-5-CARBOXAMIDE, 97%Related Search:

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1H-INDOLE-5-CARBOXAMIDE, 97%

SD-169

1H-Indole-5-carboxamide(9CI)

5-(AMinocarbonyl)-1H-indole

5-CarbaMoylindole

p38 MAP Kinase Inhibitor VII, SD-169

5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole

p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem

Indole-5-carboxamide (7CI, 8CI)

HSPs,p38α,kinases,SD-169,protein,inhibit,Inhibitor,p38 MAPK,MAPK,SD169,heat,diabete,mitogen-activated,proteins,shock

1H-indole-5-carboxamide(SD-169)

1670-87-7

AMIDE

Heterocyclic Compounds