GO 6976
- Product Name
- GO 6976
- CAS No.
- 136194-77-9
- Chemical Name
- GO 6976
- Synonyms
- G6976;GO 6976;GOE 6976;PD406976;Aids044729;Aids-044729;Go6976 Go-6976;Go6976 (PD40697);GO 6976 USP/EP/BP;InSolution? G? 6976
- CBNumber
- CB1396876
- Molecular Formula
- C24H18N4O
- Formula Weight
- 378.43
- MOL File
- 136194-77-9.mol
GO 6976 Property
- Melting point:
- >221°C (dec.)
- Boiling point:
- 652.3±55.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Acetonitrile (Very Slightly, Heated), DMSO (Slightly), Methanol (Very Slightly)
- form
- Off-white solid
- pka
- 14.39±0.20(Predicted)
- color
- White to Off-White
Safety
- Safety Statements
- 22-24/25
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 365250
- Product name
- Gö6976-CAS136194-77-9-Calbiochem
- Purity
- G?6976,CAS136194-77-9,isacell-permeable,reversible,andATP-competitivei
- Packaging
- 500μg
- Price
- $245
- Updated
- 2024/03/01
- Product number
- 365250
- Product name
- G? 6976
- Packaging
- 1mg
- Price
- $318
- Updated
- 2024/03/01
- Product number
- 13310
- Product name
- G? 6976
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $49
- Updated
- 2024/03/01
- Product number
- 13310
- Product name
- G? 6976
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $92
- Updated
- 2024/03/01
- Product number
- 365253
- Product name
- InSolution? G? 6976
- Packaging
- 1ml
- Price
- $245
- Updated
- 2024/03/01
GO 6976 Chemical Properties,Usage,Production
Uses
Go 6976 is a potent FLT3 inihibtor which is been shown to initiate cytotoxicity involving acute leukemia. Also known as a PKC inhibitor, which results into apoptosis and tumor destruction. Cancer therapeutic agent.
Definition
ChEBI: Goe 6976 is an organic heterohexacyclic compound and an indolocarbazole. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor.
Biological Activity
Potent protein kinase C (PKC) inhibitor (IC 50 = 7.9 nM). In vitro, discriminates between Ca 2+ -dependent and -independent isoforms of PKC; selectively inhibits PKC α and PKC β 1 (IC 50 values are 2.3 and 6.2 nM respectively) but does not inhibit the activity of PKC δ , - ε , or - ζ (IC 50 > 3 μ M). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC 50 values are 5, 30, 130 and 370 nM respectively).
storage
-20°C (desiccate)
References
[1]. gschwendt, m., et al., inhibition of protein kinase c mu by various inhibitors. differentiation from protein kinase c isoenzymes. febs lett, 1996. 392(2): p. 77-80.
[2]. qatsha, k.a., et al., go 6976, a selective inhibitor of protein kinase c, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro. proc natl acad sci u s a, 1993. 90(10): p. 4674-8.
[3]. joksovic, p.m., et al., mechanisms of inhibition of t-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase c pathway. mol pharmacol, 2010. 77(1): p. 87-94.
[4]. taube, e., et al., a novel treatment strategy for egfr mutant nsclc with t790m-mediated acquired resistance. int j cancer, 2012. 131(4): p. 970-9.
[5]. yoshida, a., et al., go6976, a flt3 kinase inhibitor, exerts potent cytotoxic activity against acute leukemia via inhibition of survivin and mcl-1. biochem pharmacol, 2014. 90(1): p. 16-24.
GO 6976 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GO 6976 manufacturers
- Product
- G? 6976 136194-77-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10
- Product
- GO 6976 136194-77-9
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-10