ChemicalBook > CAS DataBase List > GO 6976

GO 6976

Product Name
GO 6976
CAS No.
136194-77-9
Chemical Name
GO 6976
Synonyms
G6976;GO 6976;GOE 6976;PD406976;Aids044729;Aids-044729;Go6976 Go-6976;Go6976 (PD40697);GO 6976 USP/EP/BP;InSolution? G? 6976
CBNumber
CB1396876
Molecular Formula
C24H18N4O
Formula Weight
378.43
MOL File
136194-77-9.mol
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GO 6976 Property

Melting point:
>221°C (dec.)
Boiling point:
652.3±55.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
Acetonitrile (Very Slightly, Heated), DMSO (Slightly), Methanol (Very Slightly)
form 
Off-white solid
pka
14.39±0.20(Predicted)
color 
White to Off-White
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Safety

Safety Statements 
22-24/25
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
365250
Product name
Gö6976-CAS136194-77-9-Calbiochem
Purity
G?6976,CAS136194-77-9,isacell-permeable,reversible,andATP-competitivei
Packaging
500μg
Price
$245
Updated
2024/03/01
Sigma-Aldrich
Product number
365250
Product name
G? 6976
Packaging
1mg
Price
$318
Updated
2024/03/01
Cayman Chemical
Product number
13310
Product name
G? 6976
Purity
≥98%
Packaging
500μg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
13310
Product name
G? 6976
Purity
≥98%
Packaging
1mg
Price
$92
Updated
2024/03/01
Sigma-Aldrich
Product number
365253
Product name
InSolution? G? 6976
Packaging
1ml
Price
$245
Updated
2024/03/01
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GO 6976 Chemical Properties,Usage,Production

Uses

Go 6976 is a potent FLT3 inihibtor which is been shown to initiate cytotoxicity involving acute leukemia. Also known as a PKC inhibitor, which results into apoptosis and tumor destruction. Cancer therapeutic agent.

Definition

ChEBI: Goe 6976 is an organic heterohexacyclic compound and an indolocarbazole. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor.

Biological Activity

Potent protein kinase C (PKC) inhibitor (IC 50 = 7.9 nM). In vitro, discriminates between Ca 2+ -dependent and -independent isoforms of PKC; selectively inhibits PKC α and PKC β 1 (IC 50 values are 2.3 and 6.2 nM respectively) but does not inhibit the activity of PKC δ , - ε , or - ζ (IC 50 > 3 μ M). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC 50 values are 5, 30, 130 and 370 nM respectively).

storage

-20°C (desiccate)

References

[1]. gschwendt, m., et al., inhibition of protein kinase c mu by various inhibitors. differentiation from protein kinase c isoenzymes. febs lett, 1996. 392(2): p. 77-80.
[2]. qatsha, k.a., et al., go 6976, a selective inhibitor of protein kinase c, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro. proc natl acad sci u s a, 1993. 90(10): p. 4674-8.
[3]. joksovic, p.m., et al., mechanisms of inhibition of t-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase c pathway. mol pharmacol, 2010. 77(1): p. 87-94.
[4]. taube, e., et al., a novel treatment strategy for egfr mutant nsclc with t790m-mediated acquired resistance. int j cancer, 2012. 131(4): p. 970-9.
[5]. yoshida, a., et al., go6976, a flt3 kinase inhibitor, exerts potent cytotoxic activity against acute leukemia via inhibition of survivin and mcl-1. biochem pharmacol, 2014. 90(1): p. 16-24.

GO 6976 Preparation Products And Raw materials

Raw materials

Preparation Products

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GO 6976 Suppliers

China 90 Germany 1 India 1 Japan 1 Switzerland 2 United Kingdom 7 United States 23 Global 125
Nacalai Tesque, Inc.
Tel
--
Fax
--
Email
info-tech@nacalai.co.jp
Country
Japan
ProdList
6046
Advantage
75
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View Lastest Price from GO 6976 manufacturers

Career Henan Chemical Co
Product
G? 6976 136194-77-9
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-10
Career Henan Chemical Co
Product
GO 6976 136194-77-9
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-10

136194-77-9, GO 6976Related Search:

Indole-5-carboxaldehyde N-Ethyl-3-carbazolecarboxaldehyde 4-AMINOMETHYLINDOLE 1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE 97 N-(2-CYANOETHYL)PYRROLE Indole-4-carboxaldehyde 3-Formyl-9H-carbazole GO 6976 1-Methylindoline-5-carboxaldehyde 97% C-(9-ETHYL-9H-CARBAZOL-3-YL)-METHYLAMINE 3-METHYLCARBAZOLE 1H-INDOLE-5-CARBOXAMIDE, 97% 1-ethyl-1H-indole-5-carbaldehyde 11,12-Dihydroindolo[2,3-a]carbazole (1-METHYL-1H-INDOL-5-YL)METHYLAMINE 1-METHYL-1H-INDOLE-4-CARBALDEHYDE C-(1H-INDOL-5-YL)-METHYLAMINE K-252C

  • InSolution G 6976 - CAS 136194-77-9 - Calbiochem
  • InSolution? G? 6976
  • 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
  • Go6976,5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
  • PD406976
  • 12-(2-CYANOETHYL)-6,7,12,13-TETRAHYDRO-13-METHYL-5-OXO-5H-INDOLO(2,3-A)PYRROLO(3,4-C)-CARBAZOLE
  • 12-2(2-CYANOETHYL)-6,7,12,13-TETRAHYDRO-13-METHYL-5-OXO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE
  • GO 6976
  • G6976
  • GOE 6976
  • Go 6976, 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole
  • 12H-Indolo[2,3-A]pyrrolo[3,4-C]carbazole-12-propanenitrile, 5,6,7,13-tetrahydro-13-methyl-5-oxo-
  • Aids044729
  • Aids-044729
  • GO 6976 USP/EP/BP
  • 3-(13-Methyl-5-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)propanenitrile
  • Go6976 (PD40697)
  • Go6976 Go-6976
  • Go 6976 (DMSO solution)
  • 136194-77-9
  • Inhibitors
  • Inhibitor