C-(1H-INDOL-5-YL)-METHYLAMINE

Product Name: C-(1H-INDOL-5-YL)-METHYLAMINE
CAS No.: 81881-74-5
Chemical Name: C-(1H-INDOL-5-YL)-METHYLAMINE
Synonyms: Indole-5-methanamine;INDOLE-5-METHYLAMINE;5-(AMINOMETHYL)INDOLE;5-(aminomethyl)-indol;1H-Indole-5-MethanaMine;((Indol-5-yl)Methyl)aMine;(1H-Indol-5-yl)methylamine;(1H-INDOL-5-YL)METHANAMINE;1-(1H-Indol-5-yl)MethanaMine;C-(1H-INDOL-5-YL)-METHYLAMINE
CBNumber: CB5271243
Molecular Formula: C9H10N2
Formula Weight: 146.19
MOL File: 81881-74-5.mol

More

Less

C-(1H-INDOL-5-YL)-METHYLAMINE Property

Melting point:: 114-122 °C
Boiling point:: 335.6±17.0 °C(Predicted)
Density: 1.199±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 17.07±0.30(Predicted)
Appearance: Light yellow to brown Solid
InChI: InChI=1S/C9H10N2/c10-6-7-1-2-9-8(5-7)3-4-11-9/h1-5,11H,6,10H2
InChIKey: UAYYSAPJTRVEQA-UHFFFAOYSA-N
SMILES: N1C2=C(C=C(CN)C=C2)C=C1

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: NL4461500

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: A616825
Product name: 5-(Aminomethyl)indole
Packaging: 250mg
Price: $130
Updated: 2021/12/16

TRC

Product number: A616825
Product name: 5-(Aminomethyl)indole
Packaging: 2.5g
Price: $1055
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0115187
Product name: 5-(AMINOMETHYL)INDOLE
Purity: 95.00%
Packaging: 2.5G
Price: $1771
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0115187
Product name: 5-(AMINOMETHYL)INDOLE
Purity: 95.00%
Packaging: 250MG
Price: $716.1
Updated: 2021/12/16

AK Scientific

Product number: 2681AC
Product name: (1H-Indol-5-yl)methanamine
Packaging: 1g
Price: $86
Updated: 2021/12/16

More

Less

C-(1H-INDOL-5-YL)-METHYLAMINE Chemical Properties,Usage,Production

Uses

5-(Aminomethyl)indole is used in the synthesis of Vigabatrin (V253000) bioisosteres as inhibitors of γ-aminobutyric acid aminotransferase (GABA-AT) inhibitors.

Uses

Reactant for preparation of:

HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p75
Inhibitors of Gli1-mediated transcription in the Hedgehog pathway
SCIO-469-like compounds for the inhibition of p38 MAP kinase
4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles as protein kinase c theta (PKC θ) inhibitors
Non-covalent thrombin inhibitors

Uses

5-(AMinoMethyl)indole has been used as reactant for preparation of:• and HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p751•

Synthesis

15861-24-2

81881-74-5

The hydrogenation reaction was carried out using Raney Nickel as a catalyst in a methanol solution containing ammonia with 5-cyanoindole as starting material. After completion of the reaction, the reaction solution was concentrated under reduced pressure to give a light yellow solid product, C-(1H-indol-5-yl)-methylamine (5.25 g, quantitative yield).

References

[1] Patent: US2004/204455, 2004, A1. Location in patent: Page/Page column 18
[2] Chemistry - A European Journal, 2016, vol. 22, # 14, p. 4991 - 5002
[3] Patent: US2003/153596, 2003, A1
[4] Patent: WO2016/44770, 2016, A1. Location in patent: Page/Page column 584; 585
[5] Patent: WO2011/76784, 2011, A2. Location in patent: Page/Page column 66

C-(1H-INDOL-5-YL)-METHYLAMINE Preparation Products And Raw materials

Raw materials

Copper(I) Cyanide Ethylenediamine N-Methyl-2-pyrrolidone 5-Bromoindole Sodium cyanide Lithium Aluminum Hydride

Preparation Products

More

Less

C-(1H-INDOL-5-YL)-METHYLAMINE Suppliers

Canada 1 China 82 India 3 Switzerland 1 United Kingdom 1 United States 18 Global 106

Suzhou Lyran Biopharma And Technology CO.,LTD.

Tel: 18949975665
Email: 1184800090@qq.com
Country: China
ProdList: 347
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18729
Advantage: 57

Shanghai AmasPharm Co., Ltd.

Tel: 021-54540637 18621091017
Fax: 021-34978309
Email: sales@amaspharm.com
Country: China
ProdList: 781
Advantage: 62

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3199
Advantage: 55

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 18982182443
Email: yangli@happysyn.com
Country: China
ProdList: 2150
Advantage: 55

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

More

Less

View Lastest Price from C-(1H-INDOL-5-YL)-METHYLAMINE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: C-(1H-INDOL-5-YL)-METHYLAMINE 81881-74-5
Price: US $1.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KG
Release date: 2019-12-30

Shaanxi Dideu Medichem Co. Ltd

Product: 5-(Aminomethyl)indole 81881-74-5
Price: US $1.00-1.00/Kg/Drum
Min. Order: 1KG
Purity: 99%+
Supply Ability: 100 tons
Release date: 2019-12-26

Shaanxi Dideu Medichem Co. Ltd

Product: 5-(Aminomethyl)indole 81881-74-5
Price: US $1.00-1.00/Kg/Drum
Min. Order: 1KG
Purity: 99%+
Supply Ability: 100 tons
Release date: 2019-12-26

81881-74-5, C-(1H-INDOL-5-YL)-METHYLAMINERelated Search:

Rizatriptan benzoate FROVATRIPTAN 1-(1-Methyl-1H-indol-4-yl)methylamine 97%,(1-METHYL-1H-INDOL-4-YL)METHYLAMINE,1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE,1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE 97 C-(1H-INDOL-4-YL)-METHYLAMINE C-(1H-INDOL-2-YL)-METHYLAMINE 5-Methoxygramine, N,N-Dimethyl-(5-methoxy-1H-indol-3-yl)methylamine STAUROSPORINE C-(6,7,8,9-TETRAHYDRO-5 H-CARBAZOL-3-YL)-METHYLAMINE GO 6976 CHEMBRDG-BB 5573168 K-252A 4'-demethylamino-4'-hydroxystaurosporine K-252C C-(2,3-DIMETHYL-1H-INDOL-5-YL)-METHYLAMINE (1-METHYL-1H-INDOL-6-YL)METHYLAMINE C-(2,3,5-TRIMETHYL-1H-INDOL-7-YL)-METHYLAMINE C-(2-METHYL-1H-INDOL-5-YL)-METHYLAMINE,(2-Methyl-1H-indol-5-yl)methylamine C-(1H-INDOL-7-YL)-METHYLAMINE,1H-INDOL-7-YL-METHYLAMINE

5-(aminomethyl)-indol

INDOLE-5-METHYLAMINE

C-(1H-INDOL-5-YL)-METHYLAMINE

(1H-INDOL-5-YL)METHANAMINE

(1H-Indol-5-yl)methylamine

5-(AMINOMETHYL)INDOLE

((Indol-5-yl)Methyl)aMine

1-(1H-Indol-5-yl)MethanaMine

1H-Indole-5-MethanaMine

Indole-5-methanamine

81881-74-5

Indoles

Heterocyclic Building Blocks

Building Blocks

Amines

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

pharmacetical

Building Blocks

Heterocyclic Building Blocks

Indoles

Building Blocks

C7 to C9

Chemical Synthesis

Heterocyclic Building Blocks