ChemicalBook > CAS DataBase List > SD-208

SD-208

Product Name
SD-208
CAS No.
627536-09-8
Chemical Name
SD-208
Synonyms
SD-208;CS-2295;SCI 208;SD-208 10MG;SD-208 (SD 208;ALK5 Inhibitor V;SD-208 USP/EP/BP;TGF-β RI Kinase Inhibitor V;TGF-β RI Kinase Inhibitor V;SD-208;SD 208; SD208; SCI 208
CBNumber
CB7837155
Molecular Formula
C17H10ClFN6
Formula Weight
352.75
MOL File
627536-09-8.mol
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SD-208 Property

Boiling point:
460.4±45.0 °C(Predicted)
Density 
1.487
storage temp. 
2-8°C
solubility 
DMSO: >5mg/mL
form 
powder
pka
4.56±0.26(Predicted)
color 
off-white to tan
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S7071
Product name
SD-208
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$211
Updated
2024/03/01
Sigma-Aldrich
Product number
S7071
Product name
SD-208
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$306.4
Updated
2024/03/01
Cayman Chemical
Product number
16619
Product name
SD 208
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
16619
Product name
SD 208
Purity
≥98%
Packaging
5mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
16619
Product name
SD 208
Purity
≥98%
Packaging
10mg
Price
$178
Updated
2024/03/01
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SD-208 Chemical Properties,Usage,Production

Uses

SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2

Biological Activity

Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.

Biochem/physiol Actions

SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1

storage

Store at RT

SD-208 Preparation Products And Raw materials

Raw materials

Preparation Products

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SD-208 Suppliers

China 98 India 1 Switzerland 1 United Kingdom 2 United States 17 Global 119
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2923
Advantage
55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4271
Advantage
65
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Fax
025-83453306
Email
sales@fartop.net
Country
China
ProdList
2231
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
Zhengzhou HSH Science & Technology Co., Ltd.
Tel
0371-55932928 18937192232
Fax
0086-0371-55932928
Email
1282296214@qq.com
Country
China
ProdList
496
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3421
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58

627536-09-8, SD-208Related Search:

3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole 1H-INDOLE-5-CARBOXAMIDE, 97% xav-939 SB 431542 LY2109761 LY-364947 Lenalidomide Dabrafenib

  • SD-208
  • 2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE
  • 2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine
  • 2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
  • CS-2295
  • SD-208 (SD 208
  • SD 208;SD208;TGF-Β RI KINASE INHIBITOR V
  • 4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
  • 2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine
  • SCI 208
  • 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
  • TGF-β RI Kinase Inhibitor V
  • SD-208;SD 208; SD208; SCI 208
  • SD-208 10MG
  • ALK5 Inhibitor V
  • SD-208 USP/EP/BP
  • SD-208,inhibit,Transforming growth factor beta receptors,TGF-β Receptor,Inhibitor,SD 208
  • TGF-β RI Kinase Inhibitor V
  • 627536-09-8
  • C17H10ClFN6
  • Inhibitors
  • Smad
  • TGF-beta