ChemicalBook > CAS DataBase List > SD-208
SD-208
- Product Name
- SD-208
- CAS No.
- 627536-09-8
- Chemical Name
- SD-208
- Synonyms
- SD-208;CS-2295;SCI 208;SD-208 10MG;SD-208 (SD 208;ALK5 Inhibitor V;SD-208 USP/EP/BP;TGF-β RI Kinase Inhibitor V;TGF-β RI Kinase Inhibitor V;SD-208;SD 208; SD208; SCI 208
- CBNumber
- CB7837155
- Molecular Formula
- C17H10ClFN6
- Formula Weight
- 352.75
- MOL File
- 627536-09-8.mol
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SD-208 Property
- Boiling point:
- 460.4±45.0 °C(Predicted)
- Density
- 1.487
- storage temp.
- 2-8°C
- solubility
- DMSO: >5mg/mL
- form
- powder
- pka
- 4.56±0.26(Predicted)
- color
- off-white to tan
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- S7071
- Product name
- SD-208
- Purity
- ≥98% (HPLC), powder
- Packaging
- 5mg
- Price
- $211
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- S7071
- Product name
- SD-208
- Purity
- ≥98% (HPLC), powder
- Packaging
- 25mg
- Price
- $306.4
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16619
- Product name
- SD 208
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16619
- Product name
- SD 208
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $108
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16619
- Product name
- SD 208
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $178
- Updated
- 2024/03/01
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SD-208 Chemical Properties,Usage,Production
Uses
SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2
Biological Activity
Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.
Biochem/physiol Actions
SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1
storage
Store at RT
SD-208 Preparation Products And Raw materials
Raw materials
Preparation Products
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SD-208 Suppliers
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