ChemicalBook > CAS DataBase List > SD-208

SD-208

Product Name
SD-208
CAS No.
627536-09-8
Chemical Name
SD-208
Synonyms
SD-208;CS-2295;SCI 208;SD-208 10MG;SD-208 ，S7624;SD-208 (SD 208;ALK5 Inhibitor V;SD-208 USP/EP/BP;SD-208, 10 mM in DMSO;SD-208/627536-09-8/98%
CBNumber
CB7837155
Molecular Formula
C17H10ClFN6
Formula Weight
352.75
MOL File
627536-09-8.mol
More
Less

SD-208 Property

Boiling point:
460.4±45.0 °C(Predicted)
Density 
1.487
storage temp. 
2-8°C
solubility 
DMSO: >5mg/mL
form 
powder
pka
4.56±0.26(Predicted)
color 
off-white to tan
InChI
1S/C17H10ClFN6/c18-10-1-2-13(19)12(9-10)15-24-16-14(21-7-8-22-16)17(25-15)23-11-3-5-20-6-4-11/h1-9H,(H,20,22,23,24,25)
InChIKey
BERLXWPRSBJFHO-UHFFFAOYSA-N
SMILES
Fc1ccc(Cl)cc1-c2nc(Nc3ccncc3)c4nccnc4n2
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
Storage Class
11 - Combustible Solids
Hazard Classifications
Acute Tox. 4 Oral
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S7071
Product name
SD-208
Purity
≥98% (HPLC), powder
Packaging
5mg
Price
$244
Updated
2026/03/19
Sigma-Aldrich
Product number
S7071
Product name
SD-208
Purity
≥98% (HPLC), powder
Packaging
25mg
Price
$845
Updated
2026/03/19
Cayman Chemical
Product number
16619
Product name
SD 208
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
16619
Product name
SD 208
Purity
≥98%
Packaging
5mg
Price
$108
Updated
2024/03/01
Cayman Chemical
Product number
16619
Product name
SD 208
Purity
≥98%
Packaging
10mg
Price
$178
Updated
2024/03/01
More
Less

SD-208 Chemical Properties,Usage,Production

Uses

SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.2

Biological Activity

Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.

Biochem/physiol Actions

SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1

in vivo

SD-208 (1 mg/mL, p.o.) significantly prolongs the median survival of SMA-560 glioma-bearing mice[1]. In syngeneic 129S1 mice, SD-208 (60 mg/kg/d, p.o.) inhibits primary R3T tumor growth, and reduces the number and the size of lung metastases[2]. In the murine aortic allograft model, SD-208 effectively reduces the formation of intimal hyperplasia of transplant arteriosclerosis (TA)[3].

storage

Store at RT

SD-208 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SD-208 Suppliers

China 139 India 1 Switzerland 1 United Kingdom 2 United States 17 Global 160
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
ProdList
4267
Advantage
65
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Fax
025-83453306
Email
sales@fartop.net
Country
China
ProdList
2229
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
26322
Advantage
65
Zhengzhou HSH Science & Technology Co., Ltd.
Tel
0371-55932928 18937192232
Fax
0086-0371-55932928
Email
1282296214@qq.com
Country
China
ProdList
498
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4769
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
8000
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185;
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58

627536-09-8, SD-208Related Search:

3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole 1H-INDOLE-5-CARBOXAMIDE, 97% xav-939 SB 431542 LY2109761 LY-364947 Lenalidomide Dabrafenib

  • SD-208
  • 2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE
  • 2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine
  • 2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
  • CS-2295
  • SD-208 (SD 208
  • SD 208;SD208;TGF-Β RI KINASE INHIBITOR V
  • 4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
  • 2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine
  • SCI 208
  • 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
  • TGF-β RI Kinase Inhibitor V
  • SD-208;SD 208; SD208; SCI 208
  • SD-208 10MG
  • ALK5 Inhibitor V
  • SD-208 USP/EP/BP
  • SD-208,inhibit,Transforming growth factor beta receptors,TGF-β Receptor,Inhibitor,SD 208
  • SD-208, 10 mM in DMSO
  • SD-208/627536-09-8/98%
  • SD-208 ，S7624
  • 627536-09-8
  • 625736-09-8
  • C17H10ClFN6
  • Inhibitors
  • Smad
  • TGF-beta