SD-208

ChemicalBook > CAS DataBase List > SD-208

Product Name: SD-208
CAS No.: 627536-09-8
Chemical Name: SD-208
Synonyms: SD-208;CS-2295;SCI 208;SD-208 10MG;SD-208 (SD 208;ALK5 Inhibitor V;SD-208 USP/EP/BP;TGF-β RI Kinase Inhibitor V;TGF-β RI Kinase Inhibitor V;SD-208;SD 208; SD208; SCI 208
CBNumber: CB7837155
Molecular Formula: C17H10ClFN6
Formula Weight: 352.75
MOL File: 627536-09-8.mol

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SD-208 Property

Boiling point:: 460.4±45.0 °C(Predicted)
Density: 1.487
storage temp.: 2-8°C
solubility: DMSO: >5mg/mL
form: powder
pka: 4.56±0.26(Predicted)
color: off-white to tan

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S7071
Product name: SD-208
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $211
Updated: 2024/03/01

Sigma-Aldrich

Product number: S7071
Product name: SD-208
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $306.4
Updated: 2024/03/01

Cayman Chemical

Product number: 16619
Product name: SD 208
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 16619
Product name: SD 208
Purity: ≥98%
Packaging: 5mg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 16619
Product name: SD 208
Purity: ≥98%
Packaging: 10mg
Price: $178
Updated: 2024/03/01

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SD-208 Chemical Properties,Usage,Production

Uses

SD-208 was used to inhibit the activity of ALK5 kinase in bovine retinal vascular cells.²

Biological Activity

Potent, orally active ATP-competitive transforming growth factor- β receptor 1 (TGF- β RI) inhibitor (IC 50 = 49nM). Displays > 100-fold and > 17-fold selectivity over TGF- β RII and other common kinases respectively. Exhibits anti-inflammatory and antitumor activity.

Biochem/physiol Actions

SD-208 is an inhibitor of TGF β receptor 1 kinase that is reportedly effective against human malignant gliomas. It increases the lytic activity and tumor infiltration by polyclonal natural killer cells, CD8 T cells and macrophages.1

storage

Store at RT

SD-208 Preparation Products And Raw materials

Raw materials

Preparation Products

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SD-208 Suppliers

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627536-09-8, SD-208Related Search:

3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole 1H-INDOLE-5-CARBOXAMIDE, 97% xav-939 SB 431542 LY2109761 LY-364947 Lenalidomide Dabrafenib

SD-208

2-[(5-CHLORO-2-FLUOROPHENYL)PTERIDIN-4-YL]PYRIDIN-4-YL-AMINE

2-(5-Chloro-2-fluorophenyl)-4-[(4-pyridyl)amino]pteridine

2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine

CS-2295

SD-208 (SD 208

SD 208;SD208;TGF-Β RI KINASE INHIBITOR V

4-PteridinaMine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-

2-(5-Chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine

SCI 208

2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-

TGF-β RI Kinase Inhibitor V

SD-208;SD 208; SD208; SCI 208

SD-208 10MG

ALK5 Inhibitor V

SD-208 USP/EP/BP

SD-208,inhibit,Transforming growth factor beta receptors,TGF-β Receptor,Inhibitor,SD 208

TGF-β RI Kinase Inhibitor V

627536-09-8

C17H10ClFN6

Inhibitors

Smad

TGF-beta