3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole

Product Name: 3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole
CAS No.: 271576-80-8
Chemical Name: 3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole
Synonyms: SD-06;SD 0006;SD-06-1;CS-2591;SD 0006(SD-06);SD-06;SD 06;SD06;3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole;1-(4-(5-(4-Chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethanone;Ethanone, 1-[4-[5-(4-chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy-;1-(4-(5-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethan-1-one
CBNumber: CB62554318
Molecular Formula: C20H20ClN5O2
Formula Weight: 397.86
MOL File: 271576-80-8.mol

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3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole Property

Boiling point:: 652.6±55.0 °C(Predicted)
Density: 1.367
storage temp.: 2-8°C
solubility: DMSO : 50 mg/mL (125.67 mM; Need ultrasonic)
form: Powder
pka: 9.39±0.50(Predicted)

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC145174
Product name: 1-(4-(5-(4-Chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethanone
Packaging: 1mg
Price: $280
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001430
Product name: SD-06
Purity: 95.00%
Packaging: 1MG
Price: $340.2
Updated: 2021/12/16

ChemScene

Product number: CS-0446
Product name: SD0006
Purity: 98.60%
Packaging: 25mg
Price: $400
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC145174
Product name: 1-(4-(5-(4-Chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethanone
Packaging: 2mg
Price: $400
Updated: 2021/12/16

AK Scientific

Product number: SYN1078
Product name: SD-06
Packaging: 5mg
Price: $405
Updated: 2021/12/16

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3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole Chemical Properties,Usage,Production

Definition

ChEBI: SD-06 is a member of the class of pyrazoles that is 1H-pyrazole in which the hydrogens at positions 3, 4, and 5 are replaced by N-(hydroxyacetyl)piperidin-4-yl, pyrimidin-4-yl and p-chlorophenyl groups, respectively. It is a member of pyrazoles, a member of pyrimidines, a N-acylpiperidine, a member of monochlorobenzenes and a primary alcohol.

Biological Activity

SD 0006 (SD-06) is an orally potent, selective, ATP-competitive, and potent diarylpyrazole inhibitor of p38α MAPK with IC50 of 110 nM.

in vitro

SD 0006 clearly inhibits p38α as shown by the dose-dependent inhibition of phosphorylation of its endogenous Hsp27 substrate.

in vivo

SD 0006 (0-30 mg/kg) may be an effective alternative to steroids and biologics for RA therapy.It(3.75, 7.5 and 15 mg/kg; po; bid) is highly effective in attenuating SCW-induced inflammation as shown by the dose-dependent inhibition of paw swelling.

target

IC50: 110 nM (p38 MAPK).

3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole Suppliers

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271576-80-8, 3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazoleRelated Search:

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3-[N-(2-Hydroxyacetyl)-4-piperidyl]-4-(4-pyrimidinyl)-5-(4-chlorophenyl)pyrazole

SD-06

SD-06-1

1-(4-(5-(4-Chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethanone

SD 0006

SD-06;SD 06;SD06

SD 0006(SD-06)

CS-2591

Ethanone, 1-[4-[5-(4-chlorophenyl)-4-(4-pyrimidinyl)-1H-pyrazol-3-yl]-1-piperidinyl]-2-hydroxy-

1-(4-(5-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazol-3-yl)piperidin-1-yl)-2-hydroxyethan-1-one

271576-80-8

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