ChemicalBook > CAS DataBase List > (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

Product Name
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
CAS No.
188416-35-5
Chemical Name
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
Synonyms
N-2;6-Chloro Voriconazole;Voriconazole Impurity 9;Voriconazole Impurity 90;Voriconazole Impurity 38;rac-6-Chloro Voriconazole;Voriconazole intermediate;Voriconazole Impurity 9 HCl;Voriconazole Intermediate V5;Voriconazole 6-Chloro Racemate
CBNumber
CB1197794
Molecular Formula
C16H13ClF3N5O
Formula Weight
383.76
MOL File
188416-35-5.mol
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(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Property

Melting point:
183-187°C
Boiling point:
529.9±60.0 °C(Predicted)
Density 
1.51
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
11.44±0.29(Predicted)
color 
Off-White
CAS DataBase Reference
188416-35-5(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological
Product number
T2978-23
Product name
N2-
Packaging
5mg
Price
$425
Updated
2021/12/16
Usbiological
Product number
279415
Product name
N-2-
Packaging
25mg
Price
$446
Updated
2021/12/16
Usbiological
Product number
165574
Product name
N2-
Packaging
100mg
Price
$446
Updated
2021/12/16
Usbiological
Product number
267939
Product name
N2-
Packaging
5mg
Price
$460
Updated
2021/12/16
Usbiological
Product number
457871
Product name
N-2-
Packaging
1mg
Price
$496
Updated
2021/12/16
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(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

An achiral intermediate of Voriconazole (V760000).

(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride Suppliers

Canada 1 CHINA 153 Germany 1 India 6 United Kingdom 1 United States 11 Global 173
Cangzhou Weizhidamei Pharmaceutical Co., Ltd.
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View Lastest Price from (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride manufacturers

henan kanbei chemical co.,ltd
Product
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 188416-35-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2022-09-26
Career Henan Chemical Co
Product
(2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 188416-35-5
Price
US $7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100KG
Release date
2018-12-17

188416-35-5, (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochlorideRelated Search:

(FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE Fluorocytosine Uracil Silver sulfadiazine Cytosine Triphenylphosphine 2-Phenylphenol Sulfadiazine Voriconazole 4-Chloro-6-ethyl-5-fluoropyrimidine (trans)-6-Chloro-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol 4-Ethyl-5-fluoropyrimidine 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine Voriconazole Impurity 53 1,2,4-Triazole 2-Chloro-2',4'-difluoroacetophenone Pyrimidine, 4-bromo-6-(1-bromoethyl)-5-fluoro- (2R,3S/2S,3R)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

  • 6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-Methyl-α-(1H-1,2,4-triazol-1-ylMethyl)-4-pyriMidineethanol
  • 4-PyriMidineethanol, 6-chloro-a-(2,4-difluorophenyl)-5-fluoro-b-Methyl-a-(1H-1,2,4-triazol-1-ylMethyl)-
  • (2R,3S/2S,3R)-3-(4-CHLORO-5-FLUORO PYRIMIDIN-6-YL)-2-(2,4-DIFLUOROPHENYL)-1-(1H-1,2,4-TRIAZOL-1-YL)
  • Voriconazole (RR,SS)-6-Chloro IMpurity
  • (2S,3R)-3-(6-chloro-5-fluoropyriMidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
  • 6-Chloro Voriconazole
  • Voriconazole (RS,SR)-6-Chloro Impurity
  • N-2
  • (2R,3S/2S,3R)-3-(4-CHLORO-5-FLUORO-6-PYRIMIDINYL)-2-(2,4-DIFLUOROPHENYL)-1-(1H-1,2,4-TRIAZOL-1-YL)-2-BUTANOL HCL
  • (2R,3S/2S,3R)-3-(4-CHLORO-5-FLUORO-6-PYRIMIDINYL)-2-(2,4-DIFLUOROPHENYL)-1-(1H-1,2,4-TRIAZOL-1-YL)-2-BUTANOL HYDROCHLORIDE
  • (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
  • (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)-1- (1H-
  • (2r,3s/2s,3r)-3-(4-Chloro-5-Fluoro-6-Pyrimidinyl)-2-(2,4-Difluorophenyl)-1-(1h-1,2,4-Triazol- 1-Yl)-2- Butanol Hydrochloride
  • (2R,3S/2S,3R)-3-(6-Chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol- 1-yl)-2- butanol hydrochloride
  • (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)-1- (1H-1,2,4-triazol-1-yl)-2-butanol hydrochloride ( N-2 step)
  • (2R,3S/2S,3R)-3-(4-chloro-5-fluoro-6-pyrimidinyl)-2- (2,4-difluorophenyl)-1-(1H-1,2,4-trazol-1-yl)-2-butanol hydrochloride ( For Voriconazole )
  • (2R,3S/2S,3R)-3-(4-CHLORO-5-FLUORO-6-PYRIMIDINYL)-2-(2,4-DIFLUOROPHENYL)
  • (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-
  • rac-6-Chloro Voriconazole
  • (2R,3S/2S,3R)-3-(6-Chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanolhydrochlo
  • (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol
  • 3-(6-Chloro-5-fluoropyriMidin-4-yl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
  • (2R.3S/2S.3R) -3-(4-CHLORO-5-FLUOROPYRIMIDIN-6-YL)-2 -(2,4-D IFLUOROPHENYL)-1-(1H-1,2,4-TRIAZOL-1-YL) BUTAN-2-OL HYDROCHL
  • Voriconazole Impurity 9 HCl
  • Voriconazole Impurity 9
  • Voriconazole (RR,β)-6-Chloro Impurity-rac-6-Chloro Voriconazole
  • Voriconazole 6-Chloro Racemate
  • 4-Pyrimidineethanol, 6-chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-
  • (2R,3S/2S,3R)-3-(4-CHLORO-5-FLUOROPYRIMIDIN-6-YL)-2-(2,4-DIFLUOROPHENYL)-1-(1H-1,2,4-TRIAZOL-1-YL)BUTAN-2-OL
  • 2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
  • Voriconazole (RR,β)-6-Chloro Impurity-rac-6-Chloro Voriconazole
  • Voriconazole intermediate
  • (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 188416-35-5
  • Voriconazole Intermediate V5
  • 6-Chloro-α-(2,4-difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
  • m-Phenylenediamine-<sup-15< sup="" style="margin: 0px
  • Voriconazole Impurity 90
  • (2R,3S)/(2S,3R)-3-(4-chloro-5-fluoropyrimidin-6-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol hydrochloride (or) Chloro Voriconazole
  • Voriconazole Impurity 38
  • Voriconazole Impurity 17（Mixture of Diastereoisomer）
  • 188416-35-5
  • C9H17BrN2O2
  • C16H13ClF3N5OHCl
  • C14H13Cl2F3N2O
  • Heterocycles
  • Intermediates
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • INTERMEDIATESOFVORICONAZOLE