4-Chloro-6-ethyl-5-fluoropyrimidine

Product Name: 4-Chloro-6-ethyl-5-fluoropyrimidine
CAS No.: 137234-74-3
Chemical Name: 4-Chloro-6-ethyl-5-fluoropyrimidine
Synonyms: 4-Chloro-6-ethyl-5-fluoropyrimidin;Voriconazole Impurity 26;4-chloro-6-ethyl-5-fluorouracil;4-chloro-6-ethyl-5-fluoropyiMidine;4-chloro-6-ethyl-5-flouropyrimidine;4-CHLORO-6-ETHYL-5-FLUOROPYRIMIDINE;4-Chloro-5-fluoro-6-ethylpyriMidine;PyriMidine, 4-chloro-6-ethyl-5-fluoro-;4-Chloro-6-ethyl-5-fluoropyrimidine,95%;6-CHLORO-4-ETHYL-5-FLUORO-1,6-DIHYDROPYRIMIDINE
CBNumber: CB4709862
Molecular Formula: C6H6ClFN2
Formula Weight: 160.58
MOL File: 137234-74-3.mol

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4-Chloro-6-ethyl-5-fluoropyrimidine Property

Boiling point:: 211°C
Density: 1.286
Flash point:: 81°C
refractive index: 1.496
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform, Ethyl Acetate
pka: -0.45±0.26(Predicted)
form: Oil
color: Clear Colourless to Pale Yellow
InChI: InChI=1S/C6H6ClFN2/c1-2-4-5(8)6(7)10-3-9-4/h3H,2H2,1H3
InChIKey: LKTGVRWVTAJGMS-UHFFFAOYSA-N
SMILES: C1=NC(CC)=C(F)C(Cl)=N1
CAS DataBase Reference: 137234-74-3(CAS DataBase Reference)

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Safety

Risk Statements: 20/21/22-36/37/38-41
Safety Statements: 22-36/37/39-45-39-26
RIDADR: UN3267
HazardClass: 8
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H227Combustible liquid

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: C366095
Product name: 4-Chloro-6-ethyl-5-fluoropyrimidine
Packaging: 2.5g
Price: $185
Updated: 2021/12/16

TRC

Product number: C366095
Product name: 4-Chloro-6-ethyl-5-fluoropyrimidine
Packaging: 25g
Price: $1455
Updated: 2021/12/16

AK Scientific

Product number: J92280
Product name: 4-Chloro-6-ethyl-5-fluoropyrimidine
Packaging: 1g
Price: $10
Updated: 2021/12/16

Matrix Scientific

Product number: 075571
Product name: 4-Chloro-6-ethyl-5-fluoropyrimidine
Purity: 95+%
Packaging: 5g
Price: $23
Updated: 2021/12/16

Matrix Scientific

Product number: 075571
Product name: 4-Chloro-6-ethyl-5-fluoropyrimidine
Purity: 95+%
Packaging: 25g
Price: $38
Updated: 2021/12/16

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4-Chloro-6-ethyl-5-fluoropyrimidine Chemical Properties,Usage,Production

Chemical Properties

4-Chloro-6-ethyl-5-fluoropyrimidine is Yellow Liquid

Uses

4-Chloro-6-ethyl-5-fluoropyrimidine is a pyrimidine derivative used as a building block in the preparation of bio-active compounds such as broad-spectrum triazole antifungal agents.

Synthesis

137234-87-8

137234-74-3

Example 1: Synthesis of 4-chloro-6-ethyl-5-fluoropyrimidine <1-1> Preparation of 4-chloro-6-ethyl-5-fluoropyrimidine 80 g of 6-ethyl-5-fluoropyrimidin-4(3H)-one was dissolved in a solvent mixture of 240 mL of dichloromethane and 57.4 mL of N,N-dimethylformamide. Subsequently, 78.24 mL of triethylamine was added to the solution as a base. Phosphoryl chloride (POCl3) was slowly added dropwise to the reaction system over a period of 30 minutes. The reaction mixture was stirred under reflux conditions for 5 hours to ensure complete reaction, after which it was cooled to room temperature. 352 mL of 3N hydrochloric acid solution was carefully added to the reaction mixture at a controlled temperature not exceeding 20°C. The aqueous phase was extracted with 100 mL of dichloromethane and the organic layers were combined and washed with 100 mL of water. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to afford the oily target product 4-chloro-6-ethyl-5-fluoropyrimidine (85.9 g, 95% yield). 1H-NMR (300 MHz, CDCl3) δ (ppm): 8.70 (1H, s), 2.90 (2H, q), 1.34 (3H, t).

References

[1] Patent: WO2009/20323, 2009, A2. Location in patent: Page/Page column 7; 9
[2] Organic Process Research and Development, 2001, vol. 5, # 1, p. 28 - 36
[3] Patent: CN103896855, 2016, B. Location in patent: Paragraph 0023; 0033; 0038; 0039
[4] Patent: WO2007/13096, 2007, A1. Location in patent: Page/Page column 8
[5] Patent: WO2010/95145, 2010, A1. Location in patent: Page/Page column 17-18

4-Chloro-6-ethyl-5-fluoropyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-6-ethyl-5-fluoropyrimidine Suppliers

Canada 1 China 312 Europe 2 Germany 3 India 15 United Kingdom 8 United States 21 Global 362

Beijing Lianben Pharm-Chemicals Tech. Co.,Ltd

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Energy Chemical

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View Lastest Price from 4-Chloro-6-ethyl-5-fluoropyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Chloro-6-ethyl-5-fluoropyrimidine 137234-74-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Chloro-6-ethyl-5-fluoropyrimidine 137234-74-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-02-22

airuikechemical co., ltd.

Product: 4-chloro-6-ethyl-5-fluoropyrimidine 137234-74-3
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99.9%
Supply Ability: 200tons
Release date: 2024-04-09

137234-74-3, 4-Chloro-6-ethyl-5-fluoropyrimidineRelated Search:

Voriconazole Impurity 5 Vortioxetine Impurity 2 (2RS, 3RS)-2-(2,4-Difluorophenyl)-3-(5-fluoropyriMidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol) Voriconazole EP IMpurity E Methyl Pyridine Sulfonate Vortioxetine Impurity 22 Vortioxetine Impurity 1 Vonoprazan Impurity 41 Voriconazole Impurity 8 5-(2-Fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrole-3-carbaldehyde (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride (trans)-6-Chloro-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine Pyrimidine, 4-ethyl- (6CI,8CI,9CI) Pyrimidine, 4-chloro-6-(1,1-dibromoethyl)-5-fluoro- Voriconazole Impurity 53 2-CHLORO-1-(2,6-DIFLUOROPHENYL)ETHAN-1-ONE Voriconazole Impurity 18

4-chloro-6-ethyl-5-fluoropyiMidine

4-CHLORO-6-ETHYL-5-FLUOROPYRIMIDINE

4-chloro-6-ethyl-5-flouropyrimidine

6-CHLORO-4-ETHYL-5-FLUORO-1,6-DIHYDROPYRIMIDINE

4-Chloro-6-ethyl-5-fluoropyrimidine （Voriconazole）

Voriconazole Impurity 26

4-Chloro-6-ethyl-5-fluoropyrimidin

4-Chloro-5-fluoro-6-ethylpyriMidine

PyriMidine, 4-chloro-6-ethyl-5-fluoro-

(E)-4-chloro-6-(3-(2,4-difluorophenyl)-4-(1H-1,2,4-triazol-1-yl)but-2-en-2-yl)-5-fluoropyrimidine

4-Chloro-6-ethyl-5-fluoropyrimidine,95%

4-Chloro-6-ethyl-5-fluoropyrimidine ISO 9001：2015 REACH

4-Chloro-6-ethyl-5-fluoropyrimidine 137234-74-3

4-chloro-6-ethyl-5-fluorouracil

137234-74-3

37234-74-3

134234-74-3

C6H6ClFN2

C6H6N2ClF

Fluorine series

Pharmaceuticals

Aromatics

Heterocycles

Intermediates & Fine Chemicals

APIs & Intermediate

Pyrimidine