2-Chloro-2',4'-difluoroacetophenone

Description

Product Name: 2-Chloro-2',4'-difluoroacetophenone
CAS No.: 51336-94-8
Chemical Name: 2-Chloro-2',4'-difluoroacetophenone
Synonyms: 2-CHLORO-1-(2,4-DIFLUOROPHENYL)ETHANONE;2,4-difluorophenacyl chloride ,2-chloro-1-(2,4-difluorophenyl)ethanone;2-Chloro-2;Voriconazole RC1;TIMTEC-BB SBB006665;Voriconazole Impurity 6;2,4-DIFLUOROPHENACYL CHLORIDE;2,4-Difluorophenacylchloride98%;2,4-Difluorophenacyl chloride 98%;2'-Chloro 2,4-fluoro acetophenone
CBNumber: CB3205231
Molecular Formula: C8H5ClF2O
Formula Weight: 190.57
MOL File: 51336-94-8.mol

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2-Chloro-2',4'-difluoroacetophenone Property

Melting point:: 44-48 °C(lit.)
Boiling point:: 240.9±25.0 °C(Predicted)
Density: 1.3544 (estimate)
Flash point:: >230 °F
storage temp.: Inert atmosphere,2-8°C
solubility: Chloroform (Slightly)
form: Solid
color: Light Brown
Sensitive: Lachrymatory
BRN: 1943217
InChI: InChI=1S/C8H5ClF2O/c9-4-8(12)6-2-1-5(10)3-7(6)11/h1-3H,4H2
InChIKey: UENGBOCGGKLVJJ-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(F)C=C1F)CCl
CAS DataBase Reference: 51336-94-8(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi
Risk Statements: 34-37
Safety Statements: 26-36/37/39-45-25-27
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
F: 10-21
Hazard Note: Corrosive/Irritant/Lachrymatory
HazardClass: 8
PackingGroup: II
HS Code: 29147000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H330Fatal if inhaled

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 272507
Product name: 2-Chloro-2′,4′-difluoroacetophenone
Purity: 98%
Packaging: 5g
Price: $130
Updated: 2023/06/20

Sigma-Aldrich

Product number: 272507
Product name: 2-Chloro-2′,4′-difluoroacetophenone
Purity: 98%
Packaging: 25g
Price: $135
Updated: 2023/01/07

TCI Chemical

Product number: C2030
Product name: 2-Chloro-2',4'-difluoroacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: C2030
Product name: 2-Chloro-2',4'-difluoroacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $109
Updated: 2025/07/31

TRC

Product number: C365670
Product name: 2-Chloro-2'',4''-difluoroacetophenone
Packaging: 25g
Price: $200
Updated: 2021/12/16

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2-Chloro-2',4'-difluoroacetophenone Chemical Properties,Usage,Production

Description

2-Chloro-2′,4′-difluoroacetophenone was used in the synthesis of allyl alcohol1. It can also be tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B2.

Chemical Properties

white crystalline powder

Uses

2-Chloro-2′,4′-difluoroacetophenone was used in the synthesis of allyl alcohol.

Uses

A α-haloacetophenone derivatives tested for inhibition of protein tyrosine phosphatases SHP-1 and PTP1B.

Synthesis

372-18-9

79-04-9

51336-94-8

In a 250 mL four-necked flask equipped with a thermometer, a constant pressure dropping funnel, and a reflux condenser (with a drying tube), 1,3-difluorobenzene (0.1 mol, 14.7 g) and anhydrous aluminum trichloride (0.17 mol, 22.7 g) were added. The mixture was stirred at 30-35°C for 0.5 hours. Subsequently, chloroacetyl chloride (0.12 mol, 13.56 g) was slowly added dropwise to maintain the reaction temperature. After the dropwise addition was completed, the temperature was raised to 50-55 °C and the reaction was continued with stirring until no hydrogen chloride gas escaped, a reaction time of about 5 hours. The reaction mixture was cooled to below 5°C in an ice-water bath, and acid hydrolysis was carried out by slowly dropping 3 mol/L hydrochloric acid (20 mL), controlling the rate of dropwise acceleration to keep the temperature of the mixture low. The acid-hydrolyzed mixture was poured into a beaker and distilled water was added to precipitate the solid. After filtration and drying under reduced pressure, 16.9 g of light yellow powdery solid was obtained in 89.3% yield. Finally, the light yellow powdery solid was recrystallized with hexane to give bright yellow crystalline 2'-chloro-2,4-difluoroacetophenone.

References

[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003, vol. 42, # 2, p. 372 - 381
[2] Tetrahedron Asymmetry, 2010, vol. 21, # 13-14, p. 1649 - 1665
[3] Patent: CN106187924, 2016, A. Location in patent: Paragraph 0026; 0027
[4] Patent: CN102796080, 2016, B. Location in patent: Paragraph 0040-0042
[5] Journal of Organic Chemistry, 1995, vol. 60, # 10, p. 3000 - 3012

2-Chloro-2',4'-difluoroacetophenone Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Chloro-2',4'-difluoroacetophenone Suppliers

Americas 1 Belgium 1 Canada 2 China 256 Europe 4 France 1 Germany 6 India 31 Italy 1 Japan 5 Slovakia 1 South Korea 1 Switzerland 3 The Netherlands 1 Ukraine 2 United Kingdom 23 United States 43 Global 382

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View Lastest Price from 2-Chloro-2',4'-difluoroacetophenone manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 2-Chloro-1-(2,4-difluorophenyl)ethanone 51336-94-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-25

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-Chloro-2',4'-difluoroacetophenone 51336-94-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-19

Career Henan Chemical Co

Product: BOC-D-2-TRIFLUOROMETHYLPHENYLALANINE 51336-94-8
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-08-26

51336-94-8, 2-Chloro-2',4'-difluoroacetophenone Related Search:

4'-Bromoacetophenone 3'-Chloroacetophenone 3'-Fluoroacetophenone 1-(2,6-Difluorophenyl)ethan-1-one 2',4'-Difluoroacetophenone 4-Nitroacetophenone 3-Nitroacetophenone 4-Fluoroacetophenone 2-Chloroacetophenone 4'-Hydroxyacetophenone Trifluoroacetophenone 2',4'-Dichloroacetophenone 4'-(Trifluoromethyl)acetophenone Acetophenone 2'-Chloroacetophenone 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine Voriconazole Impurity 53 Voriconazole

2,4-difluorophenacyl chloride ,2-chloro-1-(2,4-difluorophenyl)ethanone

Chloromethyl(2,4-difluorophenyl) ketone

2-CHLORO-2',4'-DIFLUOROACETOPHEONE

2-Bhloro-2',4'-difluoroacetophenone

Ethanone,2-chloro-1-(2,4-difluorophenyl)-

2-Chloro-2',4'-difluoroacetophenone,98%

2-Chloro-2

[2-(2,4-difluorophenyl)-2-oxoethyl]chloranuide

2-Chloro-2',4'-difluoroacetophenone, 2-Chloro-1-(2,4-difluorophenyl)ethan-1-one

Voriconazole Impurity 6(RR,SS mixture)

Fluconazole Impurity 6 (2-Chloro-2’,4’-Difluoroacetophenone)

2-Chloro-2',4'-difluoroacetophenone benzenamine

2-Chloro-2',4'-difluoroacetophenone, 97+%

2-Chloro-2',4'-difluoroacetophenone 98%

Voriconazole Impurity 6

2-CHLORO-1-(2,4-DIFLUOROPHENYL)ETHANONE

2'-CHLORO-2,4-DIFLUOROACETOPHENONE

2',4'-DIFLUORO-2-CHLOROACETOPHENONE

2',4'-DIFLUORO-ALPHA-CHLOROACETOPHENONE

2',4'-DIFLUORO-ALFA-CHLOROACETOPHENONE

2,4-DIFLUOROPHENACYL CHLORIDE

ALPHA-CHLORO-2,4-DIFLUOROACETOPHENONE

TIMTEC-BB SBB006665

2,4-Difluorophenacyl chloride 98%

2,4-Difluorophenacylchloride98%

2'-Chloro 2,4-fluoro acetophenone

2-Chloro-2,4-Difluoroacetophenone/2,4-Difluoro-2-Chloro-Acetophenone

2',4'-Diflouro-2-Chloroacetophenone

a-Chloroacetyl-2,4-Difluorobenzene

α -Chloro-2,4-Difluoroacetophenone

2,4-difluoro-α-chloroacetophenone

2-Chloro-2',4'-difluoroacetophenone &gt

Voriconazole RC1

2-chloro-1-(2,4-difluorophenyl)ethanone(51336-94-8)

2,4Difluoro 1H,1yl,1,2,4Triazole Acetophenone (DFTA)

2-Chloro-2',4'-difluoroacetophenone

2',4'-DIFLUORO-2-CHLORO ACETOPHENONE (CL- COMPOUND OF DFTA IMPURITY)

51336-94-8

632-42-2

C8H5OClF2

F2C6H3COCH2Cl

Organic Building Blocks

Ketones

C7 to C8

Carbonyl Compounds

Building Blocks

Acetophenone series

Aromatics

Inhibitors

C7 to C8

Carbonyl Compounds

Ketones

blocks

FluoroCompounds

Benzene series