1-(2,6-Difluorophenyl)ethan-1-one
- Product Name
- 1-(2,6-Difluorophenyl)ethan-1-one
- CAS No.
- 13670-99-0
- Chemical Name
- 1-(2,6-Difluorophenyl)ethan-1-one
- Synonyms
- TIMTEC-BB SBB006686;2,6-DIFLUOROACETOPHENONE;2',6'-difluoroacetophenone;2',6'-Difluoroacetophenone>2',6'-Difluoroacetophenone98%;Acetophenone, 2',6'-difluoro-;1-(2,6-Difluorophenyl)ethanone;2',6'-Difluoroacetophenone 98%;Benzamide,4-(1,4-dimethylethyl)-;1-(2,6-difluorophenyl)ethan-1-one
- CBNumber
- CB7119307
- Molecular Formula
- C8H6F2O
- Formula Weight
- 156.13
- MOL File
- 13670-99-0.mol
1-(2,6-Difluorophenyl)ethan-1-one Property
- Melting point:
- 52-55°C
- Boiling point:
- 76-79 °C15 mm Hg(lit.)
- Density
- 1.197 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.48(lit.)
- Flash point:
- 170 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Liquid
- Specific Gravity
- 1.197
- color
- Clear colorless to slightly yellow
- Water Solubility
- Slightly soluble in water.
- BRN
- 2046068
- InChI
- InChI=1S/C8H6F2O/c1-5(11)8-6(9)3-2-4-7(8)10/h2-4H,1H3
- InChIKey
- VGIIILXIQLXVLC-UHFFFAOYSA-N
- SMILES
- C1C(F)=C(C(=O)C)C(F)=CC=1
- CAS DataBase Reference
- 13670-99-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethanone, 1-(2,6-difluorophenyl)-(13670-99-0)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29147000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 232890
- Product name
- 2′,6′-Difluoroacetophenone
- Purity
- 97%
- Packaging
- 1g
- Price
- $27.6
- Updated
- 2023/06/20
- Product number
- 232890
- Product name
- 2′,6′-Difluoroacetophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $55.6
- Updated
- 2023/06/20
- Product number
- D3559
- Product name
- 2',6'-Difluoroacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $65
- Updated
- 2025/07/31
- Product number
- D3559
- Product name
- 2',6'-Difluoroacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $261
- Updated
- 2025/07/31
- Product number
- D445543
- Product name
- 2'',6''-Difluoroacetophenone
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
1-(2,6-Difluorophenyl)ethan-1-one Chemical Properties,Usage,Production
Chemical Properties
Clear colourless to light yellow liquid
Uses
2?,6?-Difluoroacetophenone was used in the synthesis of 2-amino-4-alkyl- and 2-amino-4-arylquinazolines.
General Description
2′,6′-Difluoroacetophenone undergoes ruthenium-catalyzed phenylation with phenylboronate via carbon-fluorine bond cleavage to yield 2′,6′-diphenylacetophenone.
Synthesis
18063-02-0
105-53-3
13670-99-0
GENERAL STEPS: Magnesium chloride (1.65 g, 17.3 mmol) was added to a solution of diethyl malonate (1.24 g, 7.7 mmol) in ethyl acetate (20 mL) and the mixture was stirred at room temperature for 30 minutes. Subsequently, triethylamine (2.35 mL, 16.7 mmol) was added and stirring was continued for 30 minutes. The reaction mixture was cooled to 0 °C and a solution of ethyl acetate (5 mL) of 2,6-difluorobenzoyl chloride (1.0 g, 5.6 mmol) was slowly added dropwise over a period of 15 min, ensuring that the internal temperature did not exceed 5 °C. After dropwise addition, the reaction mixture was returned to room temperature and stirred for 3 hours. Upon completion of the reaction, the reaction was quenched with 1N hydrochloric acid (50 mL) and extracted with ethyl acetate (100 mL). The organic phase was separated, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to give the intermediate (1.97 g) as a colorless oil. The oil was dissolved in acetonitrile (25 mL), water (2 mL) was added, and the solution was transferred to a pressure reactor and sealed. The mixture was heated to 150 °C and kept for 1 hour. At the end of the reaction, it was cooled to room temperature and the pressure was released. The yield of 2,6-difluoroacetophenone was determined to be 874 mg (100% yield) by HPLC weight analysis.
References
[1] Patent: WO2013/85686, 2013, A1. Location in patent: Page/Page column 22
1-(2,6-Difluorophenyl)ethan-1-one Preparation Products And Raw materials
Raw materials
Preparation Products
1-(2,6-Difluorophenyl)ethan-1-one Suppliers
- Tel
- 0519-83556355 18015005120
- Fax
- -
- shikewei397@163.com
- Country
- China
- ProdList
- 3734
- Advantage
- 55
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 847-367-3680
- Fax
- 847-367-3681
- sales@arkpharminc.com
- Country
- United States
- ProdList
- 1670
- Advantage
- 56
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
View Lastest Price from 1-(2,6-Difluorophenyl)ethan-1-one manufacturers
- Product
- 1-(2,6-Difluorophenyl)ethan-1-one 13670-99-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5tons
- Release date
- 2024-12-03
- Product
- 2',6'-Difluoroacetophenone 13670-99-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.2%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- 1-(2,6-Difluorophenyl)ethanone 13670-99-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09