ChemicalBook > CAS DataBase List > 1-(2,6-Difluorophenyl)ethan-1-one

1-(2,6-Difluorophenyl)ethan-1-one

Product Name
1-(2,6-Difluorophenyl)ethan-1-one
CAS No.
13670-99-0
Chemical Name
1-(2,6-Difluorophenyl)ethan-1-one
Synonyms
TIMTEC-BB SBB006686;2,6-DIFLUOROACETOPHENONE;2',6'-difluoroacetophenone;2',6'-Difluoroacetophenone>2',6'-Difluoroacetophenone98%;Acetophenone, 2',6'-difluoro-;1-(2,6-Difluorophenyl)ethanone;2',6'-Difluoroacetophenone 98%;Benzamide,4-(1,4-dimethylethyl)-;1-(2,6-difluorophenyl)ethan-1-one
CBNumber
CB7119307
Molecular Formula
C8H6F2O
Formula Weight
156.13
MOL File
13670-99-0.mol
More
Less

1-(2,6-Difluorophenyl)ethan-1-one Property

Melting point:
52-55°C
Boiling point:
76-79 °C15 mm Hg(lit.)
Density 
1.197 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.48(lit.)
Flash point:
170 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Liquid
Specific Gravity
1.197
color 
Clear colorless to slightly yellow
Water Solubility 
Slightly soluble in water.
BRN 
2046068
InChI
InChI=1S/C8H6F2O/c1-5(11)8-6(9)3-2-4-7(8)10/h2-4H,1H3
InChIKey
VGIIILXIQLXVLC-UHFFFAOYSA-N
SMILES
C1C(F)=C(C(=O)C)C(F)=CC=1
CAS DataBase Reference
13670-99-0(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1-(2,6-difluorophenyl)-(13670-99-0)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29147000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
232890
Product name
2′,6′-Difluoroacetophenone
Purity
97%
Packaging
1g
Price
$27.6
Updated
2023/06/20
Sigma-Aldrich
Product number
232890
Product name
2′,6′-Difluoroacetophenone
Purity
97%
Packaging
5g
Price
$55.6
Updated
2023/06/20
TCI Chemical
Product number
D3559
Product name
2',6'-Difluoroacetophenone
Purity
>98.0%(GC)
Packaging
5g
Price
$65
Updated
2025/07/31
TCI Chemical
Product number
D3559
Product name
2',6'-Difluoroacetophenone
Purity
>98.0%(GC)
Packaging
25g
Price
$261
Updated
2025/07/31
TRC
Product number
D445543
Product name
2'',6''-Difluoroacetophenone
Packaging
250mg
Price
$55
Updated
2021/12/16
More
Less

1-(2,6-Difluorophenyl)ethan-1-one Chemical Properties,Usage,Production

Chemical Properties

Clear colourless to light yellow liquid

Uses

2?,6?-Difluoroacetophenone was used in the synthesis of 2-amino-4-alkyl- and 2-amino-4-arylquinazolines.

General Description

2′,6′-Difluoroacetophenone undergoes ruthenium-catalyzed phenylation with phenylboronate via carbon-fluorine bond cleavage to yield 2′,6′-diphenylacetophenone.

Synthesis

18063-02-0

105-53-3

13670-99-0

GENERAL STEPS: Magnesium chloride (1.65 g, 17.3 mmol) was added to a solution of diethyl malonate (1.24 g, 7.7 mmol) in ethyl acetate (20 mL) and the mixture was stirred at room temperature for 30 minutes. Subsequently, triethylamine (2.35 mL, 16.7 mmol) was added and stirring was continued for 30 minutes. The reaction mixture was cooled to 0 °C and a solution of ethyl acetate (5 mL) of 2,6-difluorobenzoyl chloride (1.0 g, 5.6 mmol) was slowly added dropwise over a period of 15 min, ensuring that the internal temperature did not exceed 5 °C. After dropwise addition, the reaction mixture was returned to room temperature and stirred for 3 hours. Upon completion of the reaction, the reaction was quenched with 1N hydrochloric acid (50 mL) and extracted with ethyl acetate (100 mL). The organic phase was separated, dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure to give the intermediate (1.97 g) as a colorless oil. The oil was dissolved in acetonitrile (25 mL), water (2 mL) was added, and the solution was transferred to a pressure reactor and sealed. The mixture was heated to 150 °C and kept for 1 hour. At the end of the reaction, it was cooled to room temperature and the pressure was released. The yield of 2,6-difluoroacetophenone was determined to be 874 mg (100% yield) by HPLC weight analysis.

References

[1] Patent: WO2013/85686, 2013, A1. Location in patent: Page/Page column 22

1-(2,6-Difluorophenyl)ethan-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1-(2,6-Difluorophenyl)ethan-1-one Suppliers

Americas 1 Belgium 2 China 177 Europe 4 France 3 Germany 6 India 10 Italy 1 Japan 3 Slovakia 1 Switzerland 2 The Netherlands 2 Ukraine 2 United Kingdom 23 United States 47 Global 284
Changzhou Yanji Biotechnology Co., Ltd.
Tel
0519-83556355 18015005120
Fax
-
Email
shikewei397@163.com
Country
China
ProdList
3734
Advantage
55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11035
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
021-31038972,31038973 17321035817
Fax
+86-21-51385350
Email
sales@harvest-chem.com
Country
China
ProdList
2816
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Beijing Eternalchem Co,. Ltd.
Tel
010-59484199 18611897322
Email
sales@eternalchem.com
Country
China
ProdList
4383
Advantage
60
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9815
Advantage
79
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9865
Advantage
52
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Nanjing JinruiJiuAn Biotechnology Co., Ltd.
Tel
025-58196018 800028039
Fax
025-83453306
Email
sales@fartop.net
Country
China
ProdList
2229
Advantage
55
Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Bsisun HK Imoprt And Export Company Limited
Tel
+86-18068513926
Fax
0086-519-85153711
Country
China
ProdList
1277
Advantage
55
Shanghai Yolne Chemical Co., Ltd.
Tel
021-62960152
Fax
021-52212593
Email
934678158@qq.com
Country
China
ProdList
9899
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8026
Advantage
55
Hebei Summedchem Co.,Ltd
Tel
0319-5801333-8008 15630992918
Email
sales@summedchem.com
Country
China
ProdList
965
Advantage
58
Yancheng Orgunion Pharmaceutical Sci & Tech Co., Ltd.
Tel
0515-89701588 13770166955
Fax
0515-87400189
Email
orgunion@orgunion.com
Country
China
ProdList
620
Advantage
55
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3921
Advantage
50
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2930
Advantage
58
Mei Lan Industrial (Shanghai) Co., Ltd.
Tel
021-58958189
Fax
021-58957967
Email
wouchina@126.com
Country
China
ProdList
2666
Advantage
55
Shanghai Worldyang Chemical Co.,Ltd.
Tel
021-021-56795766
Fax
+86-21-56795266
Email
sales@worldyachem.com
Country
China
ProdList
9476
Advantage
58
Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
3027
Advantage
58
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13350
Advantage
58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
Tel
0510-85629785 18013409632
Fax
051085625359
Email
sales@reading-chemicals.com
Country
China
ProdList
15178
Advantage
58
Credit-Chem Co., Ltd.
Tel
400-821-5857 021-64326257
Fax
021-64393586 QQ;2798200800
Email
credit-chem@foxmail.com
Country
China
ProdList
5219
Advantage
58
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5734
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
14912
Advantage
59
Changzhou Tianrui Pharmaceutical Technology Co., Ltd.
Tel
0519-85386832 13382812559
Fax
0519-85386832
Email
sales@cztrchem.com
Country
China
ProdList
1185
Advantage
56
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Changzhou Anxuan Chemical, Co., Ltd.
Tel
13912302692 13912302692;
Fax
0519-88064678
Email
sales@anxuanchem.com
Country
China
ProdList
4828
Advantage
58
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
More
Less

View Lastest Price from 1-(2,6-Difluorophenyl)ethan-1-one manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
1-(2,6-Difluorophenyl)ethan-1-one 13670-99-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5tons
Release date
2024-12-03
Honest Joy Holdings Limited
Product
2',6'-Difluoroacetophenone 13670-99-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98.2%
Supply Ability
100 tons
Release date
2022-01-26
Career Henan Chemical Co
Product
1-(2,6-Difluorophenyl)ethanone 13670-99-0
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-09

13670-99-0, 1-(2,6-Difluorophenyl)ethan-1-oneRelated Search:

2',6'-DIFLUOROPROPIOPHENONE 2',3',4',5',6'-PENTAFLUOROACETOPHENONE Ethyl (pentafluorobenzoyl)acetate 1-(2,6-Difluorophenyl)ethan-1-one 2',4',6'-TRIFLUOROACETOPHENONE 2,3,4,5,6-PENTAFLUOROBENZOPHENONE 2,6-DIFLUOROBENZOPHENONE PENTAFLUOROPHENACYL BROMIDE DECAFLUOROBENZOPHENONE 2',3',6'-TRIFLUOROPROPIOPHENONE 2',3',6'-TRIFLUOROACETOPHENONE 2'',4'',6''-TRIFLUOROPROPIOPHENONE 4-AMINO-3,5-DIFLUOROACETOPHENONE 3'-CHLORO-2',6'-DIFLUOROACETOPHENONE 2-CHLORO-2,2-DIFLUOROACETOPHENONE 2-Chloro-2',4'-difluoroacetophenone 2-CHLORO-2',5'-DIFLUOROACETOPHENONE 2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone

  • 1-(2,6-Difluorophenyl)ethanone
  • Acetophenone, 2',6'-difluoro-
  • TIMTEC-BB SBB006686
  • 2,6-DIFLUOROACETOPHENONE
  • 1-(2,6-difluorophenyl)ethan-1-one
  • 2',6'-Difluoroacetophenone 98%
  • 2',6'-Difluoroacetophenone98%
  • Ethanone, 1-(2,6-difluorophenyl)-
  • 1-(2,6-Difluorophenyl)ethan-1-one, 1-(2,6-Difluorophenyl)-1-oxoethane
  • 2',6'-Difluoroacetophenone&gt
  • Benzamide,4-(1,4-dimethylethyl)-
  • 2',6'-difluoroacetophenone
  • 2′,6′-Difluoroacetophenone, CAS 13670-99-0
  • 13670-99-0
  • F2C6H3COCH3
  • C8H6F2O
  • KETONE
  • Carbonyl Compounds
  • C7 to C8
  • Building Blocks
  • Ketones
  • Organic Building Blocks
  • Fluorine series
  • Indolines ,Indoles
  • C7 to C8
  • Carbonyl Compounds
  • Ketones
  • Aromatic Acetophenones & Derivatives (substituted)
  • ketone
  • Fluorobenzene
  • Miscellaneous
  • Adehydes, Acetals & Ketones
  • Fluorine Compounds