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2-CHLORO-2',5'-DIFLUOROACETOPHENONE

Product Name
2-CHLORO-2',5'-DIFLUOROACETOPHENONE
CAS No.
60468-36-2
Chemical Name
2-CHLORO-2',5'-DIFLUOROACETOPHENONE
Synonyms
5-DIFLUOROACETOPHENONE;2,5-difluorophenacyl chloride;2-CHLORO-2,5-DIFLUOROACETOPHENONE;2-Chloro-2',5'-difluoracetophenone;2-Chloro-2',5-difluoroacetophenone;2-Chloro-2',5'-difluoroacetophenone;a-Chloro-2',5'-difluoroacetophenone;2-chloro-1-(2,5-difluorophenyl)ethanone;Ethanone, 2-chloro-1-(2,5-difluorophenyl)-;2-Chloro-2′,5′-difluoroacetophenone, CAS 60468-36-2
CBNumber
CB0723282
Molecular Formula
C8H5ClF2O
Formula Weight
190.57
MOL File
60468-36-2.mol
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2-CHLORO-2',5'-DIFLUOROACETOPHENONE Property

Melting point:
49-50 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Boiling point:
240.5±25.0 °C(Predicted)
Density 
1.353±0.06 g/cm3(Predicted)
storage temp. 
Storage temp. 2-8°C
Appearance
Off-white to light brown Solid
InChI
InChI=1S/C8H5ClF2O/c9-4-8(12)6-3-5(10)1-2-7(6)11/h1-3H,4H2
InChIKey
HJWDDTDVBUFTCP-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC(F)=CC=C1F)CCl
CAS DataBase Reference
60468-36-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2914790090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C377718
Product name
2-Chloro-2'',5''-difluoroacetophenone
Packaging
100mg
Price
$45
Updated
2021/12/16
TRC
Product number
C377718
Product name
2-Chloro-2'',5''-difluoroacetophenone
Packaging
500mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC31686
Product name
2-Chloro-2',5'-difluoroacetophenone
Packaging
50g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC31686
Product name
2-Chloro-2',5'-difluoroacetophenone
Packaging
25g
Price
$50
Updated
2021/12/16
Matrix Scientific
Product number
009427
Product name
2-Chloro-2',5'-difluoroacetophenone
Purity
96%
Packaging
25g
Price
$60
Updated
2021/12/16
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2-CHLORO-2',5'-DIFLUOROACETOPHENONE Chemical Properties,Usage,Production

Chemical Properties

White solid powder

Uses

2-Chloro-2'',5''-difluoroacetophenone

Synthesis

540-36-3

79-04-9

60468-36-2

To a suspension containing aluminum trichloride (34.59 g, 259 mmol) and 1,4-difluorobenzene (20 g, 18.18 mL, 175.3 mmol), chloroacetyl chloride (21.778 g, 192.83 mmol) was slowly added dropwise at 0 °C, and the dropwise addition process was controlled to be completed within 20 minutes. The reaction mixture was stirred at 0 °C for 1 h and then warmed up to 60 °C to continue the reaction for 1 h until a clarified solution was formed. Subsequently, the reaction solution was carefully poured into about 400 mL of ice-cold 1 M hydrochloric acid. At this point, a colorless solid precipitated. The aqueous phase was extracted with ether (3 x 50 mL) and the combined organic phases were washed with saturated sodium bicarbonate solution (40 mL) and dried over anhydrous magnesium sulfate. Finally, the organic phase was concentrated by rotary evaporator to give 27.93 g (84% yield) of the colorless crystalline product 2-chloro-2',5'-difluoroacetophenone.

References

[1] Patent: WO2015/139859, 2015, A1. Location in patent: Paragraph 0079
[2] Organic Letters, 2007, vol. 9, # 4, p. 667 - 669
[3] Pharmazie, 1976, vol. 31, # 6, p. 351 - 354
[4] Tetrahedron Asymmetry, 2007, vol. 18, # 8, p. 949 - 962

2-CHLORO-2',5'-DIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-2',5'-DIFLUOROACETOPHENONE Suppliers

China 110 Europe 2 Germany 1 India 4 Japan 1 Switzerland 1 United Kingdom 10 United States 21 Global 150
Hangzhou Rydberg Biotechnology Co., Ltd
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13616542515
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3845715621@qq.com
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Liaoning Tianhua Chemical Co., Ltd.
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0418-6530555 2855550
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+86-418-6502885
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China
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Suzhou Chireach Biomedical Technology Co., Ltd.
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0512-65856968
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sales@chireach.com
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Energy Chemical
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+86 (0) 571 85 58 67 18
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0086-571-85864795
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China
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Shanghai Harvest Chemical Industrial Co., Ltd.
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+86-21-51385350
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China Langchem Inc.
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0086-21-58956006
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China
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Hangzhou Yuhao Chemical Technology Co., Ltd
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0571-82693216
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+86-571-82880190
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info@yuhaochemical.com
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China
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Nanjing Norris-Pharm Technology Co., Ltd
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18652989687
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+86-25-52131256
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View Lastest Price from 2-CHLORO-2',5'-DIFLUOROACETOPHENONE manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-Chloro-1-(2,5-difluorophenyl)ethanone 60468-36-2
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-CHLORO-2",5"-DIFLUOROACETOPHENONE 60468-36-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11
Career Henan Chemical Co
Product
2-CHLORO-2',5'-DIFLUOROACETOPHENONE 60468-36-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
JD 607 342
Release date
2019-09-01

60468-36-2, 2-CHLORO-2',5'-DIFLUOROACETOPHENONERelated Search:

2-Chloro-4,5-difluorohypnone 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone 4'-CHLORO-2',6'-DIFLUOROACETOPHENONE 3'-CHLORO-2',6'-DIFLUOROACETOPHENONE 2-Chloro-3',4'-difluoroacetophenone A-CHLORO-2',4'-DIFLUOROACETOPHENONE 2-Chloro-2',4'-difluoroacetophenone 2-CHLORO-2,2-DIFLUOROACETOPHENONE 2-CHLORO-4,5-DIFLUOROACETOPHENONE,2'-CHLORO-4',5'-DIFLUOROACETOPHENONE 2-CHLORO-2',5'-DIFLUOROACETOPHENONE 1-(2-chloroethyl)-2-fluorobenzene 3-Fluorophenacyl Chloride 2-chloro-1-(2,5-difluorophenyl)propan-1-one 2',5'-Difluoroacetophenone 4'-CHLORO-2',5'-DIFLUOROACETOPHENONE,4-CHLORO-2,5-DIFLUOROACETOPHENONE,4'-Chloro-2',5'-difluoroacetophenone 97%,4'-Chloro-2',5'-difluoroacetophenone97%

  • 2-CHLORO-2,5-DIFLUOROACETOPHENONE
  • 2,5-difluorophenacyl chloride
  • 2-chloro-1-(2,5-difluorophenyl)ethanone
  • 2,5-difluorophenacyl chloride ,2-chloro-1-(2,5-difluorophenyl)ethanone
  • 2-Chloro-1-(2,5-difluorophenyl)ethanone[2-Chloro-2',5'-difluoroacetophenone]
  • Ethanone, 2-chloro-1-(2,5-difluorophenyl)-
  • 2-CHLORO-2',5'-DIFLUOROACETOPHENONE ISO 9001：2015 REACH
  • 5-DIFLUOROACETOPHENONE
  • a-Chloro-2',5'-difluoroacetophenone
  • 2-Chloro-2',5'-difluoroacetophenone
  • 2-Chloro-2',5'-difluoracetophenone
  • 2-Chloro-2',5-difluoroacetophenone
  • 2-Chloro-2′,5′-difluoroacetophenone, CAS 60468-36-2
  • 60468-36-2
  • C8H5CIF2O
  • C8H5ClF2O
  • Fluorine series
  • Acetophenone series
  • Aromatic Acetophenones & Derivatives (substituted)
  • Benzene series