2-Chloro-1-(3,4-difluoro-phenyl)-ethanone
- Product Name
- 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone
- CAS No.
- 51336-95-9
- Chemical Name
- 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone
- Synonyms
- 2-Chloro-1-(3,4-difluorophenyl)ethan-1-one;Fluconazole Impurity 6;Ticagrelor Impurity 148;3,4-Difluorophenacyl chloride;a-Chloro-3,4-difluoroacetophenone;α-Chloro-3,4-difluorobenzophenone;2-Chloro-3',4'-difluoroacetophenone;2-chloro-1(3,4-difuorophenyl)ethanone;2-CHLORO-1-(3,4-DIFLUORO-PHENYL)-ETHANONE;Ethanone,2-chloro-1-(3,4-difluorophenyl)-
- CBNumber
- CB4366171
- Molecular Formula
- C8H5ClF2O
- Formula Weight
- 190.57
- MOL File
- 51336-95-9.mol
2-Chloro-1-(3,4-difluoro-phenyl)-ethanone Property
- Melting point:
- 31-32 °C(Solv: ethanol (64-17-5); water (7732-18-5))
- Boiling point:
- 256.3±25.0 °C(Predicted)
- Density
- 1.353±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- powder to lump
- color
- White to Light yellow
- Sensitive
- Lachrymatory
- InChI
- InChI=1S/C8H5ClF2O/c9-4-8(12)5-1-2-6(10)7(11)3-5/h1-3H,4H2
- InChIKey
- VMEDAWUIKFAFJQ-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=C(F)C(F)=C1)CCl
- CAS DataBase Reference
- 51336-95-9(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi
- RIDADR
- UN 3261 8/PG II
- HazardClass
- IRRITANT
- PackingGroup
- II
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H290May be corrosive to metals
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P234Keep only in original container.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P363Wash contaminated clothing before reuse.
P390Absorb spillage to prevent material damage.
P405Store locked up.
P406Store in corrosive resistant/… container with a resistant inner liner.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C3215
- Product name
- 2-Chloro-3',4'-difluoroacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $28
- Updated
- 2025/07/31
- Product number
- C3215
- Product name
- 2-Chloro-3',4'-difluoroacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $84
- Updated
- 2025/07/31
- Product number
- C377853
- Product name
- 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC4366
- Product name
- 3,4-Difluorophenacylchloride
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 2617-7-07
- Product name
- 3,4-Difluorophenacyl chloride
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
2-Chloro-1-(3,4-difluoro-phenyl)-ethanone Chemical Properties,Usage,Production
Uses
2-Chloro-1-(3,4-difluoro-phenyl)-ethanone is mainly used as an organic synthesis intermediate component. It can be used to prepare (1R,2R)-Ethyl 2-(3,4-difluorophenyl)cyclopropanecarboxylate, (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine (R)-2-hydroxy-2- phenylacetate, and 2-Arylcyclopropylamines.
Synthesis
2-chloro-1-(3,4-difluorophenyl)ethanone preparation steps are as follows: quickly weigh 10.2g anhydrous aluminum trichloride, (finely ground), added to a dry four-necked flask, and immediately add 11.4mL of o-difluorobenzene (dried), the middle of the mouth mounted electric stirrer, the side of the mouth, respectively, the installation of thermometers, constant-pressure dropping funnel (containing a certain amount of purified acetic anhydride, the top of the spherical condensing tube Connected to a dry tube equipped with anhydrous calcium chloride and toxic gas absorption device (absorption solution for 5% NaOH solution), under uniform stirring, from the constant pressure dropping funnel slowly dripping acetic anhydride, adjust the drop acceleration, so that the reaction temperature is controlled at 60 ?? below the temperature rise in the process of dropping, there are a large number of white gas escapes, the solution color deepens, dropping is completed, the solution is lavender viscous. Heating reflux reaction with an oil bath until no HCl gas escapes, the solution becomes light brown. Remove the gas absorption device, after cooling, the four-necked flask in a cold water bath, add a certain amount of ice-water mixture under stirring, the solids are all dissolved (if not dissolved, add a small amount of concentrated hydrochloric acid dropwise). The reaction is transferred to a partition funnel, the organic layer is separated, the aqueous layer is extracted with toluene in two batches, and finally the toluene layer is combined, the toluene layer is washed with 5% NaOH solution, distilled water, respectively, until the aqueous layer is pH=7. The toluene as well as a small amount of the water mixture is removed by rotary evaporation and recovered, and the residue is subjected to decompression distillation for the collection of 25 .
The fraction at 125-126??C at mmHg (boiling point of 2-chloro-1-(3,4-difluorophenyl)ethanone is 245-247??C at atmospheric pressure) was a brown oily liquid.
2-Chloro-1-(3,4-difluoro-phenyl)-ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone manufacturers
- Product
- 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone 51336-95-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-08
- Product
- 2-Chloro-1-(3,4-difluoro-phenyl)-ethanone 51336-95-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
- Product
- 2-Chloro-1-(3,4-difluorophenyl)ethanone 51336-95-9
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30