DIPHENYLCYCLOPROPENONE

Product Name: DIPHENYLCYCLOPROPENONE
CAS No.: 886-38-4
Chemical Name: DIPHENYLCYCLOPROPENONE
Synonyms: Diphencyprone;2,3-DIPHENYLCYCLOPROP-2-EN-1-ONE;2,3-DIPHENYL-2-CYCLOPROPEN-1-ONE;1,2-DIPHENYLCYCLOPROPEN-3-ONE;177377-5G;opropenone;RARECHEM AQ C3 0050;Diphencyclopropenone;α,β-Carbonylstilbene;iphenylcyclopropenone
CBNumber: CB2289953
Molecular Formula: C15H10O
Formula Weight: 206.24
MOL File: 886-38-4.mol

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DIPHENYLCYCLOPROPENONE Property

Melting point:: 118-122 °C (lit.)
Boiling point:: 305.09°C (rough estimate)
Density: 1.232
refractive index: 1.6324 (estimate)
storage temp.: Store below +30°C.
solubility: DMF:20.0(Max Conc. mg/mL);96.97(Max Conc. mM)
DMSO:20.0(Max Conc. mg/mL);96.97(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);2.42(Max Conc. mM)
Ethanol:14.0(Max Conc. mg/mL);67.88(Max Conc. mM)
form: Crystalline Powder
color: Slightly pinkish-orange to beige
Merck: 14,3308
BRN: 608049
InChI: InChI=1S/C15H10O/c16-15-13(11-7-3-1-4-8-11)14(15)12-9-5-2-6-10-12/h1-10H
InChIKey: HCIBTBXNLVOFER-UHFFFAOYSA-N
SMILES: C1(=O)C(C2=CC=CC=C2)=C1C1=CC=CC=C1
LogP: 1.769 (est)
CAS DataBase Reference: 886-38-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 38-43
Safety Statements: 36/37
WGK Germany: 3
HS Code: 29142990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Skin Sens. 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.20533
Product name: 2,3-Diphenyl-2-cyclopropen-1-one
Purity: for synthesis
Packaging: 1g
Price: $69.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.20533
Product name: 2,3-Diphenyl-2-cyclopropen-1-one
Purity: for synthesis
Packaging: 5G
Price: $256
Updated: 2025/07/31

Sigma-Aldrich

Product number: 177377
Product name: Diphenylcyclopropenone
Purity: 98%
Packaging: 1g
Price: $79.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 177377
Product name: Diphenylcyclopropenone
Purity: 98%
Packaging: 5g
Price: $233
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.20533
Product name: 2,3-Diphenyl-2-cyclopropen-1-one
Purity: for synthesis
Packaging: 500mg
Price: $39.4
Updated: 2023/01/07

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DIPHENYLCYCLOPROPENONE Chemical Properties,Usage,Production

Description

Diphencyprone (DCP) is a contact sensitizing agent. Pretreatment with DCP reduces symptom severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (1-10) (MBP_1-10). It enhances IL-10 production and antigen-specific IgG2a antibody responses and reduces anaphylaxis and asthma induced by ovalbumin in mice when administered during ovalbumin immunization at a concentration of 1% v/v. Topical administration of DCP increases intrafollicular CD4⁺ and CD8⁺ T cells, reduces upper dermal inflammation, and stimulates hair growth in the C3H/HeJ mouse model of alopecia areta. Formulations containing DCP have been used in the treatment of alopecia areta.

Description

Diphencyprone is a potent contact allergen responsible for occupational contact dermatitis in chemists and dermatological staff.

Chemical Properties

slightly pinkish-orange to beige crystalline

Uses

Diphenylcyclopropenone was used in topical immunotherapy.

Definition

ChEBI: A cyclopropenone compound having phenyl substituents at the 2- and 3-positions.

General Description

Diphenylcyclopropenone is a potent hapten. Its vibration frequency has been evaluated.

Contact allergens

Diphencyprone is a potent contact allergen used in topical immunotherapy to treat some severe alopecia areata. It is responsible for occupational contact dermatitis in chemists and dermatology department staff

Purification Methods

Crystallise it from cyclohexane. UV (MeCN): max 226, 282, 297nm. [Beilstein 17 IV 1736.]

References

[1] MICHAEL MEISTER . Self-Antigen Presentation by Keratinocytes in the Inflamed Adult Skin Modulates T-Cell Auto-Reactivity[J]. Journal of Investigative Dermatology, 2015, 135 8: Pages 1996-2004. DOI: 10.1038/jid.2015.130
[2] S. VON MOOS. The contact sensitizer diphenylcyclopropenone has adjuvant properties in mice and potential application in epicutaneous immunotherapy[J]. Allergy, 2012, 67 5: 638-646. DOI: 10.1111/j.1398-9995.2012.02802.x
[3] JOHN P. SUNDBERG . Alopecia Areata-Like Hair Loss in C3H/HeJ Mice and DEBR Rats Can be Reversed Using Topical Diphencyprone[J]. Journal of Investigative Dermatology Symposium Proceedings, 1999, 4 3: Page 239. DOI: 10.1038/sj.jidsp.5640219

DIPHENYLCYCLOPROPENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIPHENYLCYCLOPROPENONE Suppliers

Belgium 3 China 146 China Hong Kong 1 France 1 Germany 5 India 4 Japan 3 Slovakia 1 Switzerland 3 The Netherlands 1 United Kingdom 8 United States 23 USA 1 Global 200

Anhui Jida Pharm&Chem Co.,Ltd.

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Email: sales@jidapharm.com
Country: China
ProdList: 101
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
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3B Pharmachem (Wuhan) International Co.,Ltd.

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Fax: 86-21-50328109
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Country: China
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Alfa Aesar

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Energy Chemical

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Accela ChemBio Co.,Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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Shandong Xiya Chemical Co., Ltd

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Thermo Fisher Scientific

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9ding chemical ( Shanghai) Limited

Tel: 4009209199
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View Lastest Price from DIPHENYLCYCLOPROPENONE manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: DIPHENYLCYCLOPROPENONE 886-38-4
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-28

Xi an Biohorlden Industry Trade Co Ltd

Product: Diphenylcyclopropenone 886-38-4
Price: US $0.00/Gram
Min. Order: 10Gram
Purity: 99
Supply Ability: 500
Release date: 2025-04-10

Career Henan Chemical Co

Product: DIPHENYLCYCLOPROPENONE 886-38-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-24

886-38-4, DIPHENYLCYCLOPROPENONERelated Search:

CIS-BETA-METHYLSTYRENE 2-Phenyl-1-propene β-Methylstyrene 2-Methyl-2-butene TRANS-2-METHYL-2-BUTENAL CIS-2-BUTENE 2-PHENYL-2-BUTENE α-Methylcinnamaldehyde 1,3-DIPHENYLPROPANE Methacrolein Cinnamaldehyde Phenylacetone 3-Pentanone 1,3-Diphenylacetone Phenylacetaldehyde 1-PHENYL-2-BUTANONE CIS-STILBENE DIPHENYLCYCLOPROPENONE

Diphenylcyclopropenone 98%

2,3-Diphenyl-2-cyclopropen-1-one, 99% dry weight, may contain up to 5% water

2,3-Diphenyl-2-cyclopropen-1-one for synthesis

RARECHEM AQ C3 0050

1,2-DIPHENYLCYCLOPROPEN-3-ONE

2,3-DIPHENYL-2-CYCLOPROPEN-1-ONE

2,3-DIPHENYLCYCLOPROP-2-EN-1-ONE

2,3-Diphenyl-2-cyclopropene-1-one

2,3-Diphenyl-cycloprop-2-enone

2,3-Diphenylcyclopropenone

Cyclopropenone, 2,3-diphenyl-

Cyclopropenone, diphenyl-

2-Cyclopropen-1-one, 2,3-diphenyl-

Diphencyprone

DIPHENYLCYCLOPROPENONE

Diphenylcyclopropenone - Pharmaceutical

2,3－Diphenyl－2－cyclopropen－l－one

2,3-Diphenyl-2-cyclopropen-1-one, 99% (dry wt.), may contain up to 5% water

1,2-Diphenylcyclopropenone

Diphencyclopropenone

1,2-Diphenylcyclopropene-3-one

2,3-Diphenylcyclopropa-2-ene-1-one

α,β-Carbonylstilbene

2,3-Diphenyl-2-cyclopropen-1-one, 99% (dry wt.), may cont up to 5% water

Diphenylcyclopropenone ,99%

Diphenylcyclopropenone,98%

DiphenylcyclopropenoneDiphencyproneDPC

2,3-DIPHENYL-2-CYCLOPROPEN-1-ONE FOR SYN

opropenone

iphenylcyclopropenone

Diphenylcyclopropenon, (DCP, DPCP)

1,2-Diphenylcycelopropen-3-One

Diphenylcyclopropenone, 10 mM in DMSO

177377-5G

886-38-4

Carbonyl Compounds

C15 to C38

Building Blocks

Ketones

Organic Building Blocks

C15 to C38

Carbonyl Compounds

Ketones

Building Blocks

C15 to C38

Carbonyl Compounds

Chemical Synthesis

Organic Building Blocks