ChemicalBook > CAS DataBase List > DIPHENYLCYCLOPROPENONE

DIPHENYLCYCLOPROPENONE

Product Name
DIPHENYLCYCLOPROPENONE
CAS No.
886-38-4
Chemical Name
DIPHENYLCYCLOPROPENONE
Synonyms
Diphencyprone;2,3-DIPHENYLCYCLOPROP-2-EN-1-ONE;2,3-DIPHENYL-2-CYCLOPROPEN-1-ONE;1,2-DIPHENYLCYCLOPROPEN-3-ONE;opropenone;RARECHEM AQ C3 0050;Diphencyclopropenone;α,β-Carbonylstilbene;iphenylcyclopropenone;DIPHENYLCYCLOPROPENONE
CBNumber
CB2289953
Molecular Formula
C15H10O
Formula Weight
206.24
MOL File
886-38-4.mol
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DIPHENYLCYCLOPROPENONE Property

Melting point:
118-122 °C (lit.)
Boiling point:
305.09°C (rough estimate)
Density 
1.232
refractive index 
1.6324 (estimate)
storage temp. 
Store below +30°C.
solubility 
DMF:20.0(Max Conc. mg/mL);96.97(Max Conc. mM)
DMSO:20.0(Max Conc. mg/mL);96.97(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);2.42(Max Conc. mM)
Ethanol:14.0(Max Conc. mg/mL);67.88(Max Conc. mM)
form 
Crystalline Powder
color 
Slightly pinkish-orange to beige
Merck 
14,3308
BRN 
608049
InChIKey
HCIBTBXNLVOFER-UHFFFAOYSA-N
LogP
1.769 (est)
CAS DataBase Reference
886-38-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
38-43
Safety Statements 
36/37
WGK Germany 
3
HS Code 
29142990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.20533
Product name
2,3-Diphenyl-2-cyclopropen-1-one
Purity
for synthesis
Packaging
1g
Price
$67.3
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20533
Product name
2,3-Diphenyl-2-cyclopropen-1-one
Purity
for synthesis
Packaging
5G
Price
$249
Updated
2024/03/01
Sigma-Aldrich
Product number
177377
Product name
Diphenylcyclopropenone
Purity
98%
Packaging
1g
Price
$76.9
Updated
2024/03/01
Sigma-Aldrich
Product number
177377
Product name
Diphenylcyclopropenone
Purity
98%
Packaging
5g
Price
$226
Updated
2024/03/01
Sigma-Aldrich
Product number
8.20533
Product name
2,3-Diphenyl-2-cyclopropen-1-one
Purity
for synthesis
Packaging
500mg
Price
$39.4
Updated
2023/01/07
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DIPHENYLCYCLOPROPENONE Chemical Properties,Usage,Production

Description

Diphencyprone (DCP) is a contact sensitizing agent. Pretreatment with DCP reduces symptom severity in a mouse model of experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (1-10) (MBP1-10). It enhances IL-10 production and antigen-specific IgG2a antibody responses and reduces anaphylaxis and asthma induced by ovalbumin in mice when administered during ovalbumin immunization at a concentration of 1% v/v. Topical administration of DCP increases intrafollicular CD4+ and CD8+ T cells, reduces upper dermal inflammation, and stimulates hair growth in the C3H/HeJ mouse model of alopecia areta. Formulations containing DCP have been used in the treatment of alopecia areta.

Description

Diphencyprone is a potent contact allergen responsible for occupational contact dermatitis in chemists and dermatological staff.

Chemical Properties

slightly pinkish-orange to beige crystalline

Uses

Diphenylcyclopropenone was used in topical immunotherapy.

Definition

ChEBI: A cyclopropenone compound having phenyl substituents at the 2- and 3-positions.

General Description

Diphenylcyclopropenone is a potent hapten. Its vibration frequency has been evaluated.

Contact allergens

Diphencyprone is a potent contact allergen used in topical immunotherapy to treat some severe alopecia areata. It is responsible for occupational contact dermatitis in chemists and dermatology department staff

Purification Methods

Crystallise it from cyclohexane. UV (MeCN): max 226, 282, 297nm. [Beilstein 17 IV 1736.]

DIPHENYLCYCLOPROPENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIPHENYLCYCLOPROPENONE Suppliers

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View Lastest Price from DIPHENYLCYCLOPROPENONE manufacturers

Hebei Guanlang Biotechnology Co., Ltd.
Product
DIPHENYLCYCLOPROPENONE 886-38-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2023-02-17
Career Henan Chemical Co
Product
DIPHENYLCYCLOPROPENONE 886-38-4
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-24

886-38-4, DIPHENYLCYCLOPROPENONERelated Search:

CIS-BETA-METHYLSTYRENE 2-Phenyl-1-propene β-Methylstyrene 2-Methyl-2-butene TRANS-2-METHYL-2-BUTENAL CIS-2-BUTENE 2-PHENYL-2-BUTENE α-Methylcinnamaldehyde 1,3-DIPHENYLPROPANE Methacrolein Cinnamaldehyde Phenylacetone 3-Pentanone 1,3-Diphenylacetone Phenylacetaldehyde 1-PHENYL-2-BUTANONE CIS-STILBENE DIPHENYLCYCLOPROPENONE

  • Diphenylcyclopropenone 98%
  • 2,3-Diphenyl-2-cyclopropen-1-one, 99% dry weight, may contain up to 5% water
  • 2,3-Diphenyl-2-cyclopropen-1-one for synthesis
  • RARECHEM AQ C3 0050
  • 1,2-DIPHENYLCYCLOPROPEN-3-ONE
  • 2,3-DIPHENYL-2-CYCLOPROPEN-1-ONE
  • 2,3-DIPHENYLCYCLOPROP-2-EN-1-ONE
  • 2,3-Diphenyl-2-cyclopropene-1-one
  • 2,3-Diphenyl-cycloprop-2-enone
  • 2,3-Diphenylcyclopropenone
  • Cyclopropenone, 2,3-diphenyl-
  • Cyclopropenone, diphenyl-
  • 2-Cyclopropen-1-one, 2,3-diphenyl-
  • Diphencyprone
  • DIPHENYLCYCLOPROPENONE
  • Diphenylcyclopropenone - Pharmaceutical
  • 2,3－Diphenyl－2－cyclopropen－l－one
  • 2,3-Diphenyl-2-cyclopropen-1-one, 99% (dry wt.), may contain up to 5% water
  • 1,2-Diphenylcyclopropenone
  • Diphencyclopropenone
  • 1,2-Diphenylcyclopropene-3-one
  • 2,3-Diphenylcyclopropa-2-ene-1-one
  • α,β-Carbonylstilbene
  • 2,3-Diphenyl-2-cyclopropen-1-one, 99% (dry wt.), may cont up to 5% water
  • Diphenylcyclopropenone ,99%
  • Diphenylcyclopropenone,98%
  • DiphenylcyclopropenoneDiphencyproneDPC
  • 2,3-DIPHENYL-2-CYCLOPROPEN-1-ONE FOR SYN
  • opropenone
  • iphenylcyclopropenone
  • Diphenylcyclopropenon, (DCP, DPCP)
  • 886-38-4
  • Carbonyl Compounds
  • C15 to C38
  • Building Blocks
  • Ketones
  • Organic Building Blocks
  • C15 to C38
  • Carbonyl Compounds
  • Ketones
  • Building Blocks
  • C15 to C38
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks