ChemicalBook > CAS DataBase List > 2-CHLORO-2,2-DIFLUOROACETOPHENONE

2-CHLORO-2,2-DIFLUOROACETOPHENONE

Product Name
2-CHLORO-2,2-DIFLUOROACETOPHENONE
CAS No.
384-67-8
Chemical Name
2-CHLORO-2,2-DIFLUOROACETOPHENONE
Synonyms
2-Chloro-2,2-difluoro-1-phenylethan-1-one;Ethanone, 2-chloro-2,2-difluoro-1-phenyl-;2-Chloro-2,2-d;CHLORODIFLUOROACETOPHENONE;à,à-difluorophenacyl chloride;à-chloro-à,à-difluoroacetophene;A-CHLORO-A,A-DIFLUOROACETOPHENONE;2-CHLORO-2,2-DIFLUOROACETOPHENONE;α,α-Difluoro-α-chloroacetophenone;ChlorodifluoroMethyl phenyl ketone
CBNumber
CB7297366
Molecular Formula
C8H5ClF2O
Formula Weight
190.57
MOL File
384-67-8.mol
More
Less

2-CHLORO-2,2-DIFLUOROACETOPHENONE Property

Melting point:
102-103 °C
Boiling point:
94-96 °C35 mm Hg(lit.)
Density 
1.293 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.497(lit.)
Flash point:
163 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Difficult to mix.
form 
liquid
color 
Clear, colourless
BRN 
2251448
CAS DataBase Reference
384-67-8(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37
RIDADR 
UN 3334
WGK Germany 
3
F 
19
Hazard Note 
Irritant
HS Code 
29147000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
792373
Product name
2-Chloro-2,2-difluoroacetophenone
Purity
95%
Packaging
10g
Price
$179.4
Updated
2024/03/01
Sigma-Aldrich
Product number
792373
Product name
2-Chloro-2,2-difluoroacetophenone
Purity
95%
Packaging
1g
Price
$63.2
Updated
2023/06/20
Alfa Aesar
Product number
L16963
Product name
2-Chloro-2,2-difluoroacetophenone, 96%
Packaging
1g
Price
$96.65
Updated
2024/03/01
Alfa Aesar
Product number
L16963
Product name
2-Chloro-2,2-difluoroacetophenone, 96%
Packaging
5g
Price
$377.65
Updated
2024/03/01
TRC
Product number
C423215
Product name
2-Chloro-2,2-difluoroacetophenone
Packaging
500mg
Price
$75
Updated
2021/12/16
More
Less

2-CHLORO-2,2-DIFLUOROACETOPHENONE Chemical Properties,Usage,Production

Description

Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.

Uses

2-Chloro-2,2-difluoroacetophenone can be used:

  • As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
  • As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
  • As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

General Description

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds.

2-CHLORO-2,2-DIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-CHLORO-2,2-DIFLUOROACETOPHENONE Suppliers

China 91 Europe 2 France 1 Germany 2 India 2 Russia 1 Switzerland 2 United Kingdom 7 United States 14 Global 122
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
Beijing Eternalchem Co,. Ltd.
Tel
010-59484199 18611897322
Email
sales@eternalchem.com
Country
China
ProdList
4383
Advantage
60
Daicel Chiral Technologies (China)CO.,LTD
Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
Email
han_yajun@dctc.daicel.com
Country
China
ProdList
7191
Advantage
65
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
021-51613915-820 13611835272
Fax
021 51613951
Email
mmwang@sunwaypharm.cn
Country
China
ProdList
9734
Advantage
57
Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
971
Advantage
62
More
Less

View Lastest Price from 2-CHLORO-2,2-DIFLUOROACETOPHENONE manufacturers

Honest Joy Holdings Limited
Product
2-Chloro-2,2-difluoroacetophenone 384-67-8
Price
US $0.00/KG
Min. Order
1KG
Purity
97.8%
Supply Ability
100 tons
Release date
2022-02-21

384-67-8, 2-CHLORO-2,2-DIFLUOROACETOPHENONERelated Search:

Difluorochloromethane N-tert-Butyldimethylsilyl-2-[S-(fluoromethyl)sulfonimidoyl]pyridine, 98% 16-HEXADECANOLIDE Iodine monochloride 1-Chloropinacolone 2-CHLORO-2',5'-DIFLUOROACETOPHENONE,2-CHLORO-2,5-DIFLUOROACETOPHENONE 2-CHLORO-2,2-DIFLUOROACETOPHENONE 2,2-DIFLUOROACETOPHENONE 2'-FLUOROACETOPHENONE Phenethyl chloride 1-Chloro-1,1-difluoroethane 2-Chloro-2',4'-difluoroacetophenone 2'-CHLORO-4',5'-DIFLUOROACETOPHENONE,2-CHLORO-4,5-DIFLUOROACETOPHENONE 3'-CHLORO-2',6'-DIFLUOROACETOPHENONE 2-Chloro-3',4'-difluoroacetophenone 4'-Chloro-2',5'-difluoroacetophenone 97%,4-CHLORO-2,5-DIFLUOROACETOPHENONE,4'-CHLORO-2',5'-DIFLUOROACETOPHENONE,4'-Chloro-2',5'-difluoroacetophenone97% 4'-CHLORO-2',6'-DIFLUOROACETOPHENONE A-CHLORO-2',4'-DIFLUOROACETOPHENONE

  • CHLORODIFLUOROACETOPHENONE
  • alpha,alpha-Difluorophenacyl chloride
  • 2-CHLORO-2,2-DIFLUOROACETOPHENONE
  • A-CHLORO-A,A-DIFLUOROACETOPHENONE
  • ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENONE
  • ChlorodifluoroMethyl phenyl ketone
  • 2-Chloro-2,2-d
  • 2-chloro-2,2-difluoro-1-phenylethanone
  • 2-chloro-2,2-difluoro-1-phenyl-ethanone
  • 2-Chloro-2,2-difluoro-1-phenylethan-1-one
  • à,à-difluorophenacyl chloride
  • à-chloro-à,à-difluoroacetophene
  • 2-Chloro-2,2-difluoroacetophenone 97%
  • 2-Chloro-2,2-difluoroacetophenone97%
  • 2-CHLORO-2,2-DIFLUOROACETOPHENE, 96%
  • 1-Phenyl-2,2-difluoro-2-chloroethanone
  • Phenyl(chlorodifluoromethyl) ketone
  • α,α-Difluoro-α-chloroacetophenone
  • Ethanone, 2-chloro-2,2-difluoro-1-phenyl-
  • 384-67-8
  • C6H5COCF2Cl
  • Fluorine series