ChemicalBook > CAS DataBase List > 2-CHLORO-2,2-DIFLUOROACETOPHENONE

2-CHLORO-2,2-DIFLUOROACETOPHENONE

Product Name
2-CHLORO-2,2-DIFLUOROACETOPHENONE
CAS No.
384-67-8
Chemical Name
2-CHLORO-2,2-DIFLUOROACETOPHENONE
Synonyms
2-Chloro-2,2-difluoro-1-phenylethan-1-one;Ethanone, 2-chloro-2,2-difluoro-1-phenyl-;2-Chloro-2,2-d;CHLORODIFLUOROACETOPHENONE;Chlorodifluorobenzophenone;à,à-difluorophenacyl chloride;à-chloro-à,à-difluoroacetophene;A-CHLORO-A,A-DIFLUOROACETOPHENONE;2-CHLORO-2,2-DIFLUOROACETOPHENONE;α,α-Difluoro-α-chloroacetophenone
CBNumber
CB7297366
Molecular Formula
C8H5ClF2O
Formula Weight
190.57
MOL File
384-67-8.mol
More
Less

2-CHLORO-2,2-DIFLUOROACETOPHENONE Property

Melting point:
102-103 °C
Boiling point:
94-96 °C35 mm Hg(lit.)
Density 
1.293 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.497(lit.)
Flash point:
163 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Difficult to mix.
form 
liquid
color 
Clear, colourless
BRN 
2251448
InChI
1S/C8H5ClF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H
InChIKey
MNOONJNILVDLSW-UHFFFAOYSA-N
SMILES
FC(F)(Cl)C(=O)c1ccccc1
CAS DataBase Reference
384-67-8(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37
RIDADR 
UN 3334
WGK Germany 
3
F 
19
Hazard Note 
Irritant
HS Code 
29147000
Storage Class
10 - Combustible liquids
Hazard Classifications
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
792373
Product name
2-Chloro-2,2-difluoroacetophenone
Purity
95%
Packaging
10g
Price
$308
Updated
2025/07/31
Sigma-Aldrich
Product number
792373
Product name
2-Chloro-2,2-difluoroacetophenone
Purity
95%
Packaging
1g
Price
$63.2
Updated
2023/06/20
TRC
Product number
C423215
Product name
2-Chloro-2,2-difluoroacetophenone
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
C423215
Product name
2-Chloro-2,2-difluoroacetophenone
Packaging
500mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
2617-7-01
Product name
Chlorodifluoroacetophenone
Purity
97%
Packaging
1g
Price
$21
Updated
2021/12/16
More
Less

2-CHLORO-2,2-DIFLUOROACETOPHENONE Chemical Properties,Usage,Production

Description

Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.

Uses

2-Chloro-2,2-difluoroacetophenone can be used:

  • As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
  • As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
  • As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

General Description

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds.

reaction suitability

reaction type: C-C Bond Formation

2-CHLORO-2,2-DIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-CHLORO-2,2-DIFLUOROACETOPHENONE Suppliers

China 105 Europe 2 France 1 Germany 2 India 2 Russia 1 Switzerland 2 United Kingdom 7 United States 14 Global 136
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
11999
Advantage
60
Beijing Eternalchem Co,. Ltd.
Tel
010-59484199 18611897322
Email
sales@eternalchem.com
Country
China
ProdList
4383
Advantage
60
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8667
Advantage
57
Tongchuang Pharma(Suzhou). Co., Ltd.
Tel
0512-63263366 18912765016
Fax
0512-6326 3366
Email
tongtf110@sina.com
Country
China
ProdList
993
Advantage
62
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
6387
Advantage
52
More
Less

View Lastest Price from 2-CHLORO-2,2-DIFLUOROACETOPHENONE manufacturers

Honest Joy Holdings Limited
Product
2-Chloro-2,2-difluoroacetophenone 384-67-8
Price
US $0.00/KG
Min. Order
1KG
Purity
97.8%
Supply Ability
100 tons
Release date
2022-02-21

384-67-8, 2-CHLORO-2,2-DIFLUOROACETOPHENONERelated Search:

Difluorochloromethane N-tert-Butyldimethylsilyl-2-[S-(fluoromethyl)sulfonimidoyl]pyridine, 98% 16-HEXADECANOLIDE Iodine monochloride 1-Chloropinacolone 2-CHLORO-2',5'-DIFLUOROACETOPHENONE,2-CHLORO-2,5-DIFLUOROACETOPHENONE 2-CHLORO-2,2-DIFLUOROACETOPHENONE 2,2-DIFLUOROACETOPHENONE 2'-FLUOROACETOPHENONE Phenethyl chloride 1-Chloro-1,1-difluoroethane 2-Chloro-2',4'-difluoroacetophenone 2'-CHLORO-4',5'-DIFLUOROACETOPHENONE,2-CHLORO-4,5-DIFLUOROACETOPHENONE 3'-CHLORO-2',6'-DIFLUOROACETOPHENONE 2-Chloro-3',4'-difluoroacetophenone 4'-Chloro-2',5'-difluoroacetophenone 97%,4-CHLORO-2,5-DIFLUOROACETOPHENONE,4'-CHLORO-2',5'-DIFLUOROACETOPHENONE,4'-Chloro-2',5'-difluoroacetophenone97% 4'-CHLORO-2',6'-DIFLUOROACETOPHENONE A-CHLORO-2',4'-DIFLUOROACETOPHENONE

  • CHLORODIFLUOROACETOPHENONE
  • alpha,alpha-Difluorophenacyl chloride
  • 2-CHLORO-2,2-DIFLUOROACETOPHENONE
  • A-CHLORO-A,A-DIFLUOROACETOPHENONE
  • ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENONE
  • ChlorodifluoroMethyl phenyl ketone
  • 2-Chloro-2,2-d
  • 2-chloro-2,2-difluoro-1-phenylethanone
  • 2-chloro-2,2-difluoro-1-phenyl-ethanone
  • 2-Chloro-2,2-difluoro-1-phenylethan-1-one
  • à,à-difluorophenacyl chloride
  • à-chloro-à,à-difluoroacetophene
  • 2-Chloro-2,2-difluoroacetophenone 97%
  • 2-Chloro-2,2-difluoroacetophenone97%
  • 2-CHLORO-2,2-DIFLUOROACETOPHENE, 96%
  • 1-Phenyl-2,2-difluoro-2-chloroethanone
  • Phenyl(chlorodifluoromethyl) ketone
  • α,α-Difluoro-α-chloroacetophenone
  • Ethanone, 2-chloro-2,2-difluoro-1-phenyl-
  • Chlorodifluorobenzophenone
  • 384-67-8
  • C6H5COCF2Cl
  • Fluorine series