ChemicalBook > CAS DataBase List > 2-CHLORO-2,2-DIFLUOROACETOPHENONE

2-CHLORO-2,2-DIFLUOROACETOPHENONE

Product Name
2-CHLORO-2,2-DIFLUOROACETOPHENONE
CAS No.
384-67-8
Chemical Name
2-CHLORO-2,2-DIFLUOROACETOPHENONE
Synonyms
2-Chloro-2,2-difluoro-1-phenylethan-1-one;Ethanone, 2-chloro-2,2-difluoro-1-phenyl-;2-Chloro-2,2-d;CHLORODIFLUOROACETOPHENONE;Chlorodifluorobenzophenone;à,à-difluorophenacyl chloride;à-chloro-à,à-difluoroacetophene;A-CHLORO-A,A-DIFLUOROACETOPHENONE;2-CHLORO-2,2-DIFLUOROACETOPHENONE;α,α-Difluoro-α-chloroacetophenone
CBNumber
CB7297366
Molecular Formula
C8H5ClF2O
Formula Weight
190.57
MOL File
384-67-8.mol
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2-CHLORO-2,2-DIFLUOROACETOPHENONE Property

Melting point:
102-103 °C
Boiling point:
94-96 °C35 mm Hg(lit.)
Density 
1.293 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.497(lit.)
Flash point:
163 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Difficult to mix.
form 
liquid
color 
Clear, colourless
BRN 
2251448
CAS DataBase Reference
384-67-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37
RIDADR 
UN 3334
WGK Germany 
3
F 
19
Hazard Note 
Irritant
HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
792373
Product name
2-Chloro-2,2-difluoroacetophenone
Purity
95%
Packaging
10g
Price
$308
Updated
2025/07/31
Sigma-Aldrich
Product number
792373
Product name
2-Chloro-2,2-difluoroacetophenone
Purity
95%
Packaging
1g
Price
$63.2
Updated
2023/06/20
TRC
Product number
C423215
Product name
2-Chloro-2,2-difluoroacetophenone
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
C423215
Product name
2-Chloro-2,2-difluoroacetophenone
Packaging
500mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD30535
Product name
2,2-Difluoro-2-chloroacetophenone
Packaging
2g
Price
$76
Updated
2021/12/16
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2-CHLORO-2,2-DIFLUOROACETOPHENONE Chemical Properties,Usage,Production

Description

Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally diverse phenol derivatives and N-heterocyclic compounds.

Uses

2-Chloro-2,2-difluoroacetophenone can be used:

  • As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.
  • As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.
  • As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

General Description

2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem?-difluoromethene derived compounds.

reaction suitability

reaction type: C-C Bond Formation

2-CHLORO-2,2-DIFLUOROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-2,2-DIFLUOROACETOPHENONE Suppliers

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View Lastest Price from 2-CHLORO-2,2-DIFLUOROACETOPHENONE manufacturers

Honest Joy Holdings Limited
Product
2-Chloro-2,2-difluoroacetophenone 384-67-8
Price
US $0.00/KG
Min. Order
1KG
Purity
97.8%
Supply Ability
100 tons
Release date
2022-02-21

384-67-8, 2-CHLORO-2,2-DIFLUOROACETOPHENONERelated Search:

Difluorochloromethane N-tert-Butyldimethylsilyl-2-[S-(fluoromethyl)sulfonimidoyl]pyridine, 98% 16-HEXADECANOLIDE Iodine monochloride 1-Chloropinacolone 2-CHLORO-2',5'-DIFLUOROACETOPHENONE,2-CHLORO-2,5-DIFLUOROACETOPHENONE 2-CHLORO-2,2-DIFLUOROACETOPHENONE 2,2-DIFLUOROACETOPHENONE 2'-FLUOROACETOPHENONE Phenethyl chloride 1-Chloro-1,1-difluoroethane 2-Chloro-2',4'-difluoroacetophenone 2'-CHLORO-4',5'-DIFLUOROACETOPHENONE,2-CHLORO-4,5-DIFLUOROACETOPHENONE 3'-CHLORO-2',6'-DIFLUOROACETOPHENONE 2-Chloro-3',4'-difluoroacetophenone 4'-Chloro-2',5'-difluoroacetophenone 97%,4-CHLORO-2,5-DIFLUOROACETOPHENONE,4'-CHLORO-2',5'-DIFLUOROACETOPHENONE,4'-Chloro-2',5'-difluoroacetophenone97% 4'-CHLORO-2',6'-DIFLUOROACETOPHENONE A-CHLORO-2',4'-DIFLUOROACETOPHENONE

  • CHLORODIFLUOROACETOPHENONE
  • alpha,alpha-Difluorophenacyl chloride
  • 2-CHLORO-2,2-DIFLUOROACETOPHENONE
  • A-CHLORO-A,A-DIFLUOROACETOPHENONE
  • ALPHA-CHLORO-ALPHA,ALPHA-DIFLUOROACETOPHENONE
  • ChlorodifluoroMethyl phenyl ketone
  • 2-Chloro-2,2-d
  • 2-chloro-2,2-difluoro-1-phenylethanone
  • 2-chloro-2,2-difluoro-1-phenyl-ethanone
  • 2-Chloro-2,2-difluoro-1-phenylethan-1-one
  • à,à-difluorophenacyl chloride
  • à-chloro-à,à-difluoroacetophene
  • 2-Chloro-2,2-difluoroacetophenone 97%
  • 2-Chloro-2,2-difluoroacetophenone97%
  • 2-CHLORO-2,2-DIFLUOROACETOPHENE, 96%
  • 1-Phenyl-2,2-difluoro-2-chloroethanone
  • Phenyl(chlorodifluoromethyl) ketone
  • α,α-Difluoro-α-chloroacetophenone
  • Ethanone, 2-chloro-2,2-difluoro-1-phenyl-
  • Chlorodifluorobenzophenone
  • 384-67-8
  • C6H5COCF2Cl
  • Fluorine series