1H-INDOLE-5-CARBOXAMIDE, 97%
- Product Name
- 1H-INDOLE-5-CARBOXAMIDE, 97%
- CAS No.
- 1670-87-7
- Chemical Name
- 1H-INDOLE-5-CARBOXAMIDE, 97%
- Synonyms
- SD-169;5-CarbaMoylindole;5-(AMinocarbonyl)-1H-indole;1H-Indole-5-carboxamide(9CI);1H-INDOLE-5-CARBOXAMIDE, 97%;1H-indole-5-carboxamide(SD-169);Indole-5-carboxamide (7CI, 8CI);p38 MAP Kinase Inhibitor VII, SD-169;p38 MAP Kinase Inhibitor VII, SD-169 - CAS 1670-87-7 - Calbiochem;5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole
- CBNumber
- CB0972248
- Molecular Formula
- C9H8N2O
- Formula Weight
- 160.17
- MOL File
- 1670-87-7.mol
1H-INDOLE-5-CARBOXAMIDE, 97% Property
- Melting point:
- 159-163 °C
- Boiling point:
- 457.6±18.0 °C(Predicted)
- Density
- 1.328±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Off-white solid
- pka
- 16.25±0.30(Predicted)
- color
- Off-White to Light Purple
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 506158
- Product name
- p38 MAP Kinase Inhibitor VII, SD-169
- Packaging
- 10mg
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 14156
- Product name
- SD 169
- Purity
- ≥97%
- Packaging
- 5mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 14156
- Product name
- SD 169
- Purity
- ≥97%
- Packaging
- 10mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 14156
- Product name
- SD 169
- Purity
- ≥97%
- Packaging
- 25mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- I615500
- Product name
- 1H-Indole-5-carboxamide
- Packaging
- 10g
- Price
- $950
- Updated
- 2021/12/16
1H-INDOLE-5-CARBOXAMIDE, 97% Chemical Properties,Usage,Production
Uses
SD 169 is a selective ATP competitive inhibitor of the MAP kinases p38α (IC50 = 3.2 nM) and p38β (IC50 = 122 nM). It has no inhibitory effect against a panel of other kinases, including p38γ MAP kinase, ERK2, JNK-1, and MAPKAPK-2, when tested in vitro at 50 μM. SD 169 is orally active, significantly reducing p38 MAP kinase expression in T cells of nonobese diabetic mice when delivered in chow at 600 mg/kg. In this model, SD 169 also reduced the incidence of diabetes, lowered blood glucose, and improved glucose homeostasis. SD 169 also enhances axonal regeneration after sciatic nerve crush injury in rats, when given by gavage (30 mg/kg) before and after nerve damage.
Uses
1H-Indole-5-carboxamide (SD-169) is a p38α MAPK-selective inhibitor. 1H-Indole-5-carboxamide (SD-169) prevents the development and progression of diabetes in nonobese diabetic (NOD) mice by inhibiting T cell infiltration and activation.
Definition
ChEBI: 1H-indole-5-carboxamide is an indolecarboxamide.
Biological Activity
Selective, orally active, ATP-competitive inhibitor of p38 α MAPK (IC 50 values are 3.2, 122 and > 50000 nM for p38 α , p38 β and p38 γ respectively). Demonstrates no activity against a range of other kinases including ERK2, JNK1 and MAPKAP2. Prevents development of diabetes and alleviates mild and moderate hyperglycaemic states in NOD mice.
References
[1] medicherla s, protter a a, ma j y, et al. preventive and therapeutic potential of p38α-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes[j]. journal of pharmacology and experimental therapeutics, 2006, 318(1): 99-107.
[2] myers r r, sekiguchi y, kikuchi s, et al. inhibition of p38 map kinase activity enhances axonal regeneration[j]. experimental neurology, 2003, 184(2): 606-614.
1H-INDOLE-5-CARBOXAMIDE, 97% Preparation Products And Raw materials
Raw materials
Preparation Products
1H-INDOLE-5-CARBOXAMIDE, 97% Suppliers
View Lastest Price from 1H-INDOLE-5-CARBOXAMIDE, 97% manufacturers
- Product
- 1H-INDOLE-5-CARBOXAMIDE, 97% 1670-87-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1H-INDOLE-5-CARBOXAMIDE 1670-87-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12
- Product
- 1H-INDOLE-5-CARBOXAMIDE, 97% 1670-87-7
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-20