ChemicalBook > CAS DataBase List > ANTIBIOTIC UCN-02

ANTIBIOTIC UCN-02

Product Name
ANTIBIOTIC UCN-02
CAS No.
121569-61-7
Chemical Name
ANTIBIOTIC UCN-02
Synonyms
UCN-02;UCN02,UCN 02;ANTIBIOTIC UCN-02;9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-, (3S,9S,10R,11R,13R)-;9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-, (3S,9S,10R,11R,13R)-
CBNumber
CB42446750
Molecular Formula
C28H26N4O4
Formula Weight
482.53
MOL File
121569-61-7.mol
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ANTIBIOTIC UCN-02 Property

Boiling point:
705.7±60.0 °C(Predicted)
Density 
1.63±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
solution in ethanol.
pka
12.25±0.70(Predicted)
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

Cayman Chemical
Product number
20221
Product name
UCN-02
Purity
≥95%
Packaging
1mg
Price
$299
Updated
2024/03/01
Cayman Chemical
Product number
20221
Product name
UCN-02
Purity
≥95%
Packaging
5mg
Price
$1121
Updated
2024/03/01
Usbiological
Product number
A2297-39A
Product name
Antibiotic UCN-02
Packaging
1mg
Price
$523
Updated
2021/12/16
ApexBio Technology
Product number
C4829
Product name
UCN-02
Packaging
5mg(solution)
Price
$1432
Updated
2021/12/16
ApexBio Technology
Product number
C4829
Product name
UCN-02
Packaging
1mg(solution)
Price
$408
Updated
2021/12/16
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ANTIBIOTIC UCN-02 Chemical Properties,Usage,Production

Description

UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01 first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. UCN-02 inhibits protein kinase C with a slightly reduced potency than UCN-01 (IC50 = 62 and 4.1 nM, for UNC-02 and UCN-01, respectively) and is cytotoxic to the growth of HeLa S3 cells.

Uses

UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.

Uses

UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing?Streptomyces?culture. Related analogs of staurosporine which is non-specific protein kinase inhibitor.

References

[1] takahashi, i. ,saitoh, y.,yoshida, m., et al. ucn-01 and ucn-02, new selective inhibitors of protein kinase c. ii. purification, physico-chemical properties, structural determination and biological activities. j.antibiot.(tokyo) 42(4), 571-576 (1989).
[2] newton a c. protein kinase c: structure, function, and regulation[j]. journal of biological chemistry, 1995, 270(48): 28495-28498.

ANTIBIOTIC UCN-02 Preparation Products And Raw materials

Raw materials

Preparation Products

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121569-61-7, ANTIBIOTIC UCN-02Related Search:

UCF-101 9-ISOPROPYLCARBAZOLE 1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE 97 INDOLE-4-METHANOL 4-AMINOMETHYLINDOLE N-Ethyl-3-carbazolecarboxaldehyde Indole-4-carboxaldehyde K-252C (1-METHYL-1H-INDOL-4-YL)METHANOL (1-Methyl-1H-indol-5-yl)methanol C-(9-ETHYL-9H-CARBAZOL-3-YL)-METHYLAMINE 1-ethyl-1H-indole-5-carbaldehyde ANTIBIOTIC UCN-02 1H-INDOLE-5-CARBOXAMIDE, 97% (1-METHYL-1H-INDOL-5-YL)METHYLAMINE CARBAZOL-9-YL-METHANOL 11,12-Dihydroindolo[2,3-a]carbazole 1-METHYL-1H-INDOLE-4-CARBALDEHYDE

  • UCN-02
  • ANTIBIOTIC UCN-02
  • 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-, (3S,9S,10R,11R,13R)-
  • UCN02,UCN 02
  • 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-, (3S,9S,10R,11R,13R)-
  • 121569-61-7