UCF-101

Product Name: UCF-101
CAS No.: 313649-08-0
Chemical Name: UCF-101
Synonyms: UCF-101;UCF 101, 10 mM in DMSO;HIGH TEMPERATURE REQUIREMENT A2 INHIBITOR I;Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem;5-[5-(2-NITROPHENYL)FURFURYLIDINE]-1,3-DIPHENYL-2-THIOBARBITURIC ACID;5-[[5-(2-nitrophenyl)furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione;5-((5-(2-Nitrophenyl)furan-2-yl)methylene)-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;Dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione;4,6(1H,5H)-Pyrimidinedione, dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-;5-[[5-[2-(dihydroxyamino)phenyl]furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione
CBNumber: CB7773190
Molecular Formula: C27H17N3O5S
Formula Weight: 495.51
MOL File: Mol file

More

Less

UCF-101 Property

Boiling point:: 651.8±65.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
pka: -0.92±0.20(Predicted)
form: powder
color: light orange to dark orange
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
InChI: InChI=1S/C27H17N3O5S/c31-25-22(17-20-15-16-24(35-20)21-13-7-8-14-23(21)30(33)34)26(32)29(19-11-5-2-6-12-19)27(36)28(25)18-9-3-1-4-10-18/h1-17H
InChIKey: NVNSXBXKNMWKEJ-UHFFFAOYSA-N
SMILES: C1(=S)N(C2=CC=CC=C2)C(=O)/C(=C\C2=CC=C(C3=CC=CC=C3[N+]([O-])=O)O2)/C(=O)N1C1=CC=CC=C1

More

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1105
Product name: UCF-101
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $123
Updated: 2025/07/31

Cayman Chemical

Product number: 15550
Product name: UCF 101
Purity: ≥98%
Packaging: 1mg
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 15550
Product name: UCF 101
Purity: ≥98%
Packaging: 5mg
Price: $78
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1105
Product name: UCF-101
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $489
Updated: 2025/07/31

Cayman Chemical

Product number: 15550
Product name: UCF 101
Purity: ≥98%
Packaging: 10mg
Price: $138
Updated: 2024/03/01

More

Less

UCF-101 Chemical Properties,Usage,Production

Description

UCF-101 (313649-08-0) is a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, mitochondrial serine protease Omi/HtrA2 (IC50?= 9.5 μM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50?≥ 200 μM).1?Mitigates streptozotocin-induced cardiomyocyte dysfunction.2?Protects against cerebral oxidative injury and cognitive impairment in a rat model.3? Cell permeable.

Uses

UCF 101 is a specific inhibitor of Omi/HtrA2, a proapoptotic mitochondrial serine protease. UCF 101 has the neuroprotective effects on cerebral oxidative injury and cognitive impairment in septic rats.

in vitro

ucf 101 was identified in a hts of a combinatorial library using omi-(134-458) protease and fluorescein-casein as a generic substrate. ucf 101 exhibited specific activity against omi/htra2 and very little activity against other serine proteases. ucf 101 showed a natural fluorescence that was used to monitor its ability to enter mammalian cells. in addition, when tested in caspase-9 (-/-) null fibroblasts, ucf 101 was able to inhibit omi/htra2-induced cell death [1].

in vivo

in a previous study, rats were intraperitoneally administered ucf-101 at 1.5 micromol/kg 10 min prior to reperfusion. results showed that ucf-101 treatment could significantly decrease cerebral infarct size by about 16.27% and also improve neurological behavior. moreover, ucf-101 treatment was able to reduce tunel-positive cells in the cerebral cortex significantly. in addition, the upregulation in the expression of fasl and the cleavage products of active caspase-3 and caspase-8 induced by ischemia was attenuated in mice treated with ucf-101, while upregulation of flip levels was increased [2].

IC 50

9.5 μm

References

[1] LUCIA CILENTI. Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.[J]. The Journal of Biological Chemistry, 2003, 278 13: 11489-11494. DOI:10.1074/jbc.m212819200
[2] QUN LI Jun R Ji Li. UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMPK.[J]. American journal of physiology. Endocrinology and metabolism, 2009, 297 4: E965-73. DOI:10.1152/ajpendo.00323.2009
[3] YUEYU HU . Ucf-101 protects against cerebral oxidative injury and cognitive impairment in septic rat[J]. International immunopharmacology, 2013, 16 1: Pages 108-113. DOI:10.1016/j.intimp.2013.03.019

UCF-101 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

UCF-101 Suppliers

China 51 India 1 Switzerland 1 United States 11 Global 64

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4757
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
Advantage: 65

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4989
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

313649-08-0, UCF-101Related Search:

PUROMYCIN DIHYDROCHLORIDE Auranofin A23187 FCCP ANTIBIOTIC UCN-02 1,3-DIPHENYL-2-THIOBARBITURIC ACID

Dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione

UCF-101

HIGH TEMPERATURE REQUIREMENT A2 INHIBITOR I

5-[5-(2-NITROPHENYL)FURFURYLIDINE]-1,3-DIPHENYL-2-THIOBARBITURIC ACID

5-[[5-(2-nitrophenyl)furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione

Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem

5-[[5-[2-(dihydroxyamino)phenyl]furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione

4,6(1H,5H)-Pyrimidinedione, dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-

Omi,red,Ucf-101,UCF 101,inhibit,pro-apoptotic,543,HtrA2,MI/R,Inhibitor,cardioprotective,His-Omi,Apoptosis,neuroprotective,protease,Ucf101,fluorescence

5-((5-(2-Nitrophenyl)furan-2-yl)methylene)-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione

UCF 101, 10 mM in DMSO

313649-08-0

C27H17N3O5S