UCF-101
- Product Name
- UCF-101
- CAS No.
- 313649-08-0
- Chemical Name
- UCF-101
- Synonyms
- UCF-101;HIGH TEMPERATURE REQUIREMENT A2 INHIBITOR I;Omi/HtrA2 Protease Inhibitor, Ucf-101 - CAS 313649-08-0 - Calbiochem;5-[5-(2-NITROPHENYL)FURFURYLIDINE]-1,3-DIPHENYL-2-THIOBARBITURIC ACID;5-[[5-(2-nitrophenyl)furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione;5-((5-(2-Nitrophenyl)furan-2-yl)methylene)-1,3-diphenyl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;Dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione;4,6(1H,5H)-Pyrimidinedione, dihydro-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-;5-[[5-[2-(dihydroxyamino)phenyl]furan-2-yl]methylidene]-1,3-diphenyl-2-sulfanylidene-1,3-diazinane-4,6-dione;Omi,red,Ucf-101,UCF 101,inhibit,pro-apoptotic,543,HtrA2,MI/R,Inhibitor,cardioprotective,His-Omi,Apoptosis,neuroprotective,protease,Ucf101,fluorescence
- CBNumber
- CB7773190
- Molecular Formula
- C27H17N3O5S
- Formula Weight
- 495.51
- MOL File
- Mol file
UCF-101 Property
- Boiling point:
- 651.8±65.0 °C(Predicted)
- Density
- 1.50±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble5mg/mL, clear (warmed)
- form
- powder
- pka
- -0.92±0.20(Predicted)
- color
- light orange to dark orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1105
- Product name
- UCF-101
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 15550
- Product name
- UCF 101
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
- Product number
- 15550
- Product name
- UCF 101
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- SML1105
- Product name
- UCF-101
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $476
- Updated
- 2024/03/01
- Product number
- 15550
- Product name
- UCF 101
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
UCF-101 Chemical Properties,Usage,Production
Description
UCF-101 (313649-08-0) is a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, mitochondrial serine protease Omi/HtrA2 (IC50?= 9.5 μM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50?≥ 200 μM).1?Mitigates streptozotocin-induced cardiomyocyte dysfunction.2?Protects against cerebral oxidative injury and cognitive impairment in a rat model.3? Cell permeable.
Uses
UCF 101 is a specific inhibitor of Omi/HtrA2, a proapoptotic mitochondrial serine protease. UCF 101 has the neuroprotective effects on cerebral oxidative injury and cognitive impairment in septic rats.
in vitro
ucf 101 was identified in a hts of a combinatorial library using omi-(134-458) protease and fluorescein-casein as a generic substrate. ucf 101 exhibited specific activity against omi/htra2 and very little activity against other serine proteases. ucf 101 showed a natural fluorescence that was used to monitor its ability to enter mammalian cells. in addition, when tested in caspase-9 (-/-) null fibroblasts, ucf 101 was able to inhibit omi/htra2-induced cell death [1].
in vivo
in a previous study, rats were intraperitoneally administered ucf-101 at 1.5 micromol/kg 10 min prior to reperfusion. results showed that ucf-101 treatment could significantly decrease cerebral infarct size by about 16.27% and also improve neurological behavior. moreover, ucf-101 treatment was able to reduce tunel-positive cells in the cerebral cortex significantly. in addition, the upregulation in the expression of fasl and the cleavage products of active caspase-3 and caspase-8 induced by ischemia was attenuated in mice treated with ucf-101, while upregulation of flip levels was increased [2].
IC 50
9.5 μm
References
1) Cilenti?et al. (2003),?Characteristics of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2; J. Biol. Chem.,?278?11489 2) Li?et al.?(2009),?UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMPK; Am. J. Physiol. Endocrinol. Metab.,?297?E965 3) Hu?et al.?(2013),?Ucf-101 protects against cerebral oxidative injury and cognitive impairment in septic rat; Int. Immunopharmacol.,?16?108
UCF-101 Preparation Products And Raw materials
Raw materials
Preparation Products
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