Lestaurtinib

Product Name: Lestaurtinib
CAS No.: 111358-88-4
Chemical Name: Lestaurtinib
Synonyms: SP 924;SPM-924;CS-1165;CEP 701;KT 5555;ritatinib;A 154475.0;lestaurtinib;KT-5555 hydrate;CEP-701 hydrate
CBNumber: CB3506750
Molecular Formula: C26H21N3O4
Formula Weight: 439.47
MOL File: 111358-88-4.mol

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Lestaurtinib Property

Melting point:: 215-220°C
Boiling point:: 723.0±60.0 °C(Predicted)
Density: 1.70±0.1 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
solubility: DMSO: >10mg/mL
form: white powder
pka: 13.37±0.40(Predicted)
color: White or off-white
Stability:: Photosensitive
InChIKey: LPOQWFBZBJTLEO-GMEYHWBASA-N
SMILES: O.C[C@]12O[C@H](C[C@]1(O)CO)n3c4ccccc4c5c6C(=O)NCc6c7c8ccccc8n2c7c35

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Safety

WGK Germany: 3
HS Code: 2934999090
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C7869
Product name: CEP-701 hydrate
Purity: ≥98% (HPLC)
Packaging: 1mg
Price: $192
Updated: 2025/07/31

Sigma-Aldrich

Product number: C7869
Product name: CEP-701 hydrate
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $747
Updated: 2025/07/31

Cayman Chemical

Product number: 12094
Product name: Lestaurtinib
Purity: ≥98%
Packaging: 500μg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 12094
Product name: Lestaurtinib
Purity: ≥98%
Packaging: 1mg
Price: $70
Updated: 2024/03/01

Cayman Chemical

Product number: 12094
Product name: Lestaurtinib
Purity: ≥98%
Packaging: 5mg
Price: $151
Updated: 2024/03/01

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Lestaurtinib Chemical Properties,Usage,Production

Description

Lestaurtinib (111358-88-4) is a potent and selective FLT3 inhibitor (IC50= 2 nM).1,2Inhibits RET and RET phosphorylation in medullary thyroid carcinoma cells.3Suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders.4Potent Trk inhibitor.5Cell permeable.

Chemical Properties

Lestaurtinib is Off-White Solid

Uses

Lestaurtinib is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML)

Uses

CEP-701 hydrate has been used as a tyrosine kinase inhibitor:

to study its effects on early growth response protein (EGR) genes and nerve growth factor (NGF) stimulation in human epithelial cells
as a supplement in reservoir solution for co-crystallization studies with human receptor-interactingprotein kinase4 (RIPK4)
as an FMS-like tyrosine kinase 3 (FLT3) inhibitor-gold nanoparticle conjugate to study its effects on acute myeloid leukemia

Uses

It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).

Definition

ChEBI: LSM-1231 is an indolocarbazole.

Biological Activity

Potent JAK2, FLT3 and TrkA inhibitor (IC 50 values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC 50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC 50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo .

Biochem/physiol Actions

CEP-701 hydrate, also known as Lestaurtinib, can repress Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5) signaling by the specific inhibition of JAK2.

storage

-20°C (desiccate)

References

[1] MARK LEVIS Donald S. Novel FLT3 tyrosine kinase inhibitors.[J]. Expert opinion on investigational drugs, 2003, 12 12: 1951-1962. DOI:10.1517/13543784.12.12.1951
[2] PEILI CHEN. FLT3/ITD mutation signaling includes suppression of SHP-1.[J]. The Journal of Biological Chemistry, 2005, 280 7: 5361-5369. DOI:10.1074/jbc.m411974200
[3] CHRISTOPHER J STROCK. CEP-701 and CEP-751 inhibit constitutively activated RET tyrosine kinase activity and block medullary thyroid carcinoma cell growth.[J]. Cancer research, 2003: 5559-5563.
[4] ELIZABETH O HEXNER. Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders.[J]. Blood, 2008: 5663-5671. DOI:10.1182/blood-2007-04-083402
[5] B A RUGGERI. Role of neurotrophin-trk interactions in oncology: the anti-tumor efficacy of potent and selective trk tyrosine kinase inhibitors in pre-clinical tumor models.[J]. Current medicinal chemistry, 1999, 6 9: 845-857.

Lestaurtinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Lestaurtinib Suppliers

Canada 1 China 108 India 8 United Kingdom 4 United States 19 Global 140

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 12952
Advantage: 65

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2864
Advantage: 52

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Jinan Mingya Medical Technology Co., Ltd.

Tel: 0531-85828981
Fax: +86-531-85806006
Email: 864598798@qq.com
Country: China
ProdList: 588
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

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View Lastest Price from Lestaurtinib manufacturers

Sinoway Industrial co., ltd.

Product: Lestaurtinib 111358-88-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-12-30

Qiuxian Baitai New Material Co., LTD

Product: Larotrectinib 111358-88-4
Price: US $1.30/g
Min. Order: 1g
Purity: 99%
Supply Ability: 500ton/Month
Release date: 2021-10-29

Dideu Industries Group Limited

Product: Lestaurtinib 111358-88-4
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-06

111358-88-4, LestaurtinibRelated Search:

Dasatinib monohydrate Sunitinib Lapatinib Gefitinib Imatinib Erlotinib Ethyl 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate Mubritinib 4-(3-Chloro-4-fluorophenylamino)-7-methoxy-6-[3-(4-morpholinyl)propoxy]quinazoline dihydrochloride 2-Aminoethylmethylsulfone hydrochloride Saracatinib Bosutinib N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Canertinib dihydrochloride Tilisolol Teniposide KT5823

Lestaurtinib (KT-5555

CS-1165

lestaurtinib

(9S-(9α,10β,12α))-2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxyMethyl)-9-Methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one

SPM-924

CEP-701 hydrate

KT-5555 hydrate

Lestaurtinib hydrate

(15S,16S,18R)-16-HYDROXY-16-(HYDROXYMETHYL)-15-METHYL-28-OXA-4,14,19-TRIAZAOCTACYCLO[12.11.2.1^{15,18}.0^{2,6}.0^{7,27}.0^{8,13}.0^{19,26}.0^{20,25}]OCTACOSA-1(26),2(6),7(27),8,10,12,20,22,24-NONAEN-3-ONE

A 154475.0

(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:321kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one

CEP 701

KT 5555

SP 924

LESTAURTINIB (CEP-701;KT-5555)

9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)-

KT5555-Lestaurtinib

Lestaurtinib USP/EP/BP

ritatinib

Come on, he's replacing Ni

111358-88-4

C26H21N3O4

Inhibitor

Intermediates & Fine Chemicals

Pharmaceuticals