Lestaurtinib
- Product Name
- Lestaurtinib
- CAS No.
- 111358-88-4
- Chemical Name
- Lestaurtinib
- Synonyms
- SP 924;SPM-924;CS-1165;CEP 701;KT 5555;ritatinib; A 154475.0;lestaurtinib;KT-5555 hydrate;CEP-701 hydrate
- CBNumber
- CB3506750
- Molecular Formula
- C26H21N3O4
- Formula Weight
- 439.47
- MOL File
- 111358-88-4.mol
Lestaurtinib Property
- Melting point:
- 215-220°C
- Boiling point:
- 723.0±60.0 °C(Predicted)
- Density
- 1.70±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- DMSO: >10mg/mL
- form
- white powder
- pka
- 13.37±0.40(Predicted)
- color
- White or off-white
- Stability:
- Photosensitive
Safety
- WGK Germany
- 3
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C7869
- Product name
- CEP-701 hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 1mg
- Price
- $187
- Updated
- 2024/03/01
- Product number
- C7869
- Product name
- CEP-701 hydrate
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $727
- Updated
- 2024/03/01
- Product number
- 12094
- Product name
- Lestaurtinib
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 12094
- Product name
- Lestaurtinib
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $70
- Updated
- 2024/03/01
- Product number
- 12094
- Product name
- Lestaurtinib
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $151
- Updated
- 2024/03/01
Lestaurtinib Chemical Properties,Usage,Production
Description
Lestaurtinib (111358-88-4) is a potent and selective FLT3 inhibitor (IC50= 2 nM).1,2?Inhibits RET and RET phosphorylation in medullary thyroid carcinoma cells.3?Suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders.4?Potent Trk inhibitor.5?Cell permeable.
Chemical Properties
Lestaurtinib is Off-White Solid
Uses
Lestaurtinib is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML)
Uses
It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).
Uses
CEP-701 hydrate has been used as a tyrosine kinase inhibitor:
- to study its effects on early growth response protein (EGR) genes and nerve growth factor (NGF) stimulation in human epithelial cells
- as a supplement in reservoir solution for co-crystallization studies with human receptor-interacting?protein kinase?4 (RIPK4)
- as an FMS-like tyrosine kinase 3 (FLT3) inhibitor-gold nanoparticle conjugate to study its effects on acute myeloid leukemia
Definition
ChEBI: LSM-1231 is an indolocarbazole.
Biological Activity
Potent JAK2, FLT3 and TrkA inhibitor (IC 50 values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC 50 = 20 - 30 nM). Exhibits antiproliferative activity in vitro (IC 50 = 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disorders in vivo .
Biochem/physiol Actions
CEP-701 hydrate, also known as Lestaurtinib, can repress Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5) signaling by the specific inhibition of JAK2.
storage
-20°C (desiccate)
References
1) Levis?et al. (2003),?Novel FLT3 tyrosine kinase inhibitors; Expert Opin. Investig. Drugs,?12?1951 2) Chen?et al.?(2005),?FLT3/ITD Mutation Signaling Includes Suppression of SHP-1; J. Biol. Chem.,?280?5361 3) Strock?et al. (2003),?CEP-701 and CEP-751 Inhibit Constitutively Activated RET Tyrosine Kinase Activity and Block Medullary Thyroid Carcinoma Cell Growth; Cancer Res.,?63?5559 4) Hexner?et al. (2008),?Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders; Blood,?111?5663 5) Ruggeri?et al. (1999),?Role of neurotrophin-trk interactions in oncology: the anti-tumor efficacy of potent and selective trk tyrosine kinase inhibitors in pre-clinical tumor models; Curr. Med. Chem.,?6?845
Lestaurtinib Preparation Products And Raw materials
Raw materials
Preparation Products
Lestaurtinib Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 1-(800)-881-8210
- Fax
- 615-250-9817
- inquiries@lgmpharma.com
- Country
- United States
- ProdList
- 2127
- Advantage
- 70
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32344
- Advantage
- 50
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 14059
- Advantage
- 65
- Tel
- 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
- Fax
- +86-27-87599188
- Country
- China
- ProdList
- 1494
- Advantage
- 55
- Tel
- sales@witofly.com
- Country
- China
- ProdList
- 2867
- Advantage
- 52
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9906
- Advantage
- 55
- Tel
- 021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 7934
- Advantage
- 58
- Tel
- 0531-85828981
- Fax
- +86-531-85806006
- 864598798@qq.com
- Country
- China
- ProdList
- 588
- Advantage
- 58
View Lastest Price from Lestaurtinib manufacturers
- Product
- Larotrectinib 111358-88-4
- Price
- US $1.30/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 500ton/Month
- Release date
- 2021-10-29
- Product
- Lestaurtinib 111358-88-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-07-06