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Mubritinib

Product Name
Mubritinib
CAS No.
366017-09-6
Chemical Name
Mubritinib
Synonyms
CS-522;TAK 165;MUBRITINIB;TAK165;TAK-165;Mubritinib 99%;Mubritinib(TAK 165);Mubritinib USP/EP/BP;Mubritinib, 10 mM in DMSO;(E)-1-(4-(4-((2-(4-(trifluoromethyl)styryl)oxazol-4-yl)methoxy)phenyl)butyl)-1H-1,2,3-triazole;(E)-4-((4-(4-(1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole
CBNumber
CB21011746
Molecular Formula
C25H23F3N4O2
Formula Weight
468.47
MOL File
366017-09-6.mol
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Mubritinib Property

Melting point:
158.0 to 162.0 °C
Boiling point:
620.9±65.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO : 50 mg/mL (106.73 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
pka
1.45±0.10(Predicted)
form 
powder to crystal
color 
White to Gray to Brown
InChI
InChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
InChIKey
ZTFBIUXIQYRUNT-MDWZMJQESA-N
SMILES
N1(CCCCC2=CC=C(OCC3=COC(/C=C/C4=CC=C(C(F)(F)F)C=C4)=N3)C=C2)C=CN=N1
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Safety

HS Code 
2934.99.4400
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1312
Product name
Mubritinib
Purity
≥98% (HPLC)
Packaging
5MG
Price
$76.2
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1312
Product name
Mubritinib
Purity
≥98% (HPLC)
Packaging
25MG
Price
$297
Updated
2025/07/31
TCI Chemical
Product number
M3058
Product name
Mubritinib
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$167
Updated
2025/07/31
TCI Chemical
Product number
M3058
Product name
Mubritinib
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$497
Updated
2025/07/31
Cayman Chemical
Product number
12096
Product name
Mubritinib
Purity
≥98%
Packaging
5mg
Price
$39
Updated
2024/03/01
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Mubritinib Chemical Properties,Usage,Production

Uses

Treatment of cancer.

Uses

Mubritinib is used in selective targeting of CTNNB1-, KRAS-or MYC-driven human cancer cell growth by combinations of existing drugs

Biological Activity

Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC 50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC 50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo .

in vivo

In the xenograft model, treatment with Mubritinib (TAK-165) significantly inhibits growth of UMUC-3, ACHN, and LN-REC4. The antitumor effect after 14 days treatment are 22.9%, 26.0%, and 26.5% in UMUC3, ACHN and LN-REC4, respectively[1].

IC 50

HER2: 6 nM (IC50)

storage

Store at +4°C

Mubritinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Mubritinib Suppliers

Americas 1 China 146 Europe 2 Germany 1 India 2 Japan 1 United Kingdom 4 United States 21 Global 178
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
Taizhou Chuanxu Pharmaceutical Technology Co., Ltd.
Tel
13000000000
Email
974144639@qq.com
Country
China
ProdList
9979
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
Advantage
59
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Jinan Trio PharmaTech Co., Ltd.
Tel
0531-88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com
Country
China
ProdList
1856
Advantage
62
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View Lastest Price from Mubritinib manufacturers

Sinoway Industrial co., ltd.
Product
Mubritinib 366017-09-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20tons
Release date
2025-02-18
Zhuozhou Wenxi import and Export Co., Ltd
Product
Mubritinib 366017-09-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Mubritinib 366017-09-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

366017-09-6, MubritinibRelated Search:

2-Methoxyethanol tert-Butylchlorodiphenylsilane Anisole Nizatidine Dasatinib monohydrate PHENYL VALERATE VINYL PROPIONATE 1,4-Adamantandiol 4-Methoxyphenylacetone (Trifluoromethoxy)benzene Lapatinib Gefitinib Imatinib Pralmorelin Sunitinib Phenylhydrazine Vinyl ester resin Trifluoromethyl

  • MUBRITINIB
  • 1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole
  • TAK 165
  • Mubritinib(TAK 165)
  • CS-522
  • TAK165;TAK-165
  • (E)-1-(4-(4-((2-(4-(trifluoromethyl)styryl)oxazol-4-yl)methoxy)phenyl)butyl)-1H-1,2,3-triazole
  • 1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole Mubritinib (TAK 165)
  • Mubritinib 1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole
  • (E)-4-((4-(4-(1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole
  • 1H-1,2,3-Triazole, 1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-
  • Mubritinib USP/EP/BP
  • Mubritinib, 10 mM in DMSO
  • Mubritinib 99%
  • 366017-09-6
  • C25H23F3N4O2
  • Inhibitors