GHRP-2

Product Name: GHRP-2
CAS No.: 158861-67-7
Chemical Name: GHRP-2
Synonyms: GHRP-2;GHRP;CHRP-2;GHRP-2 ACETATE;GHCA;EIF3A;d-ala-β-(2-naphthyl)-d-ala-trp-d-phe-lys amide;-2;-2;p-ERK1
CBNumber: CB1104514
Molecular Formula: C45H55N9O6
Formula Weight: 817.97
MOL File: 158861-67-7.mol

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GHRP-2 Property

Melting point:: 149 - 151°C
Boiling point:: 1265.3±65.0 °C(Predicted)
Density: 1.270±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO (Slightly, Sonicated), Water (Slightly)
form: lyophilized powder
pka: 13.40±0.46(Predicted)
color: white to beige
Stability:: Hygroscopic
InChI: InChI=1S/C45H55N9O6/c1-27(47)41(56)52-38(24-30-19-20-31-14-6-7-15-32(31)22-30)43(58)50-28(2)42(57)53-39(25-33-26-49-35-17-9-8-16-34(33)35)45(60)54-37(23-29-12-4-3-5-13-29)44(59)51-36(40(48)55)18-10-11-21-46/h3-9,12-17,19-20,22,26-28,36-39,49H,10-11,18,21,23-25,46-47H2,1-2H3,(H2,48,55)(H,50,58)(H,51,59)(H,52,56)(H,53,57)(H,54,60)/t27-,28+,36+,37-,38-,39+/m1/s1
InChIKey: HRNLPPBUBKMZMT-RDRUQFPZSA-N
SMILES: C(N)(=O)[C@H](CCCCN)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](C)NC(=O)[C@@H](CC1=CC=C2C(=C1)C=CC=C2)NC(=O)[C@@H](C)N
CAS DataBase Reference: 158861-67-7(CAS DataBase Reference)

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2056
Product name: Pralmorelin trifluoroacetate salt
Purity: ≥97% (HPLC)
Packaging: 1MG
Price: $162
Updated: 2023/01/07

Sigma-Aldrich

Product number: SML2056
Product name: Pralmorelin trifluoroacetate salt
Purity: ≥97% (HPLC)
Packaging: 5MG
Price: $650
Updated: 2023/01/07

Alfa Aesar

Product number: J66029
Product name: Growth Hormone Releasing Peptide-2
Packaging: 25mg
Price: $270
Updated: 2021/12/16

Alfa Aesar

Product number: J66029
Product name: Growth Hormone Releasing Peptide-2
Packaging: 5mg
Price: $113
Updated: 2021/12/16

Usbiological

Product number: 382744
Product name: EIF3A
Packaging: 96Tests
Price: $729
Updated: 2021/12/16

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GHRP-2 Chemical Properties,Usage,Production

Description

Pralmorelin (also known as KP-102, GPA-748, GHRP-2, and Growth Hormone Releasing Peptide-2) is a potent GH secretagogue in development as a diagnostic agent for growth hormone deficiency and for the treatment of pituitary disorders and GH deficiency. It acts as signal molecules that are involved in the control of cell growth and differentiation.

Uses

Growth hormone releasing factor. Pralmorelin is a growth hormone secretagogue that acts on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone release.

Definition

ChEBI: Pralmorelin is an oligopeptide.

benefits

Regulation of blood pressure, increased strength and healing, reduced injury, increased cell rejuvenation, increase in lean muscle mass and stronger bones.

Biochem/physiol Actions

Pralmorelin, also known as Growth hormone-releasing peptide 2 or GHRP-2, is an orally-active, synthetic peptide analogue of met-enkephalin that acts as a ghrelin/growth hormone secretagogue receptor (GHSR) agonist to selectively stimulate the ghrelin receptor and cause growth hormone release. Pralmorelin (GHRP-2) has been used clinically for the assessment of growth hormone deficiency (GHD), It has also been shown to have anti-inflammatory activity.

Mechanism of action

GHRP-2 is an agonist of ghrelin, a gut peptide and also known as “the hunger hormone”, which binds to the growth hormone secretagogue receptor. Pralmorelin works to enhance natural growth hormone production in two ways. First, the GHRP-2 intensifies the natural growth hormone releasing signal, resulting in a substantial secretion of growth hormone. Second, it suppresses a hormone in the body called somatostatin, also known as growth hormone inhibiting hormone (GHIH). Somatostatin generates the body to decrease its natural growth hormone production. By restricting the activity of somatostatin, GHRP-2 can improve growth hormone creation, resulting in increased natural growth hormone levels. GHRP-2 also activates ghrelin, a peptide hormone produced in the gastrointestinal system, which has strong effects on growth hormone production and appetite.

Side effects

No side effects or toxicities were observed. Thus, GHRP-2 is well tolerated and can stimulate GH secretion. Formulations or routes of administration that allow for a longer duration of action will likely be needed to use GHRP-2 in therapy[1].

References

[1] V Mericq. “Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children.” Journal of Clinical Endocrinology & Metabolism 83 7 (1998): 2355–60.

GHRP-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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GHRP-2 Suppliers

Australia 1 China 250 Europe 1 France 1 Germany 2 India 2 South Korea 1 Switzerland 1 The Netherlands 1 United States 19 Global 279

Alabiochem Tech.Co., Ltd.

Tel: 0512-58900862 400-0707518
Fax: 0086-512-56765862
Email: sales@alabiochem.com
Country: China
ProdList: 995
Advantage: 59

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Cellmano Biotech Limited

Tel: 0551-65326643 18156095617
Fax: 0551-65326641
Email: info@cellmano.com
Country: China
ProdList: 1011
Advantage: 55

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

UHN Shanghai Research & Development Co., Ltd.

Tel: 021-58958002 18930822973
Fax: +86 (21) 5895-8628
Email: SALES@UHNSHANGHAI.COM
Country: China
ProdList: 977
Advantage: 58

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

Nanjing Sunlida Biological Technology Co., Ltd.

Tel: 025-57798810
Fax: 025-57019371
Email: sales@sunlidabio.com
Country: China
ProdList: 3239
Advantage: 55

Shanghai Meishui Chemical Technology Co., Ltd

Tel: 021-60549325 18616193163
Fax: 021-33250306
Country: China
ProdList: 4526
Advantage: 56

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View Lastest Price from GHRP-2 manufacturers

Shanghai Longyu Biotechnology Co., Ltd.

Product: GHRP-2 158861-67-7
Price: US $1.00/box
Min. Order: 1box
Purity: 99.99
Supply Ability: 2000000BOXES
Release date: 2024-11-21

Huaian Banting Trading Co., Ltd.

Product: GHRP-2 Acetate 158861-67-7
Price: US $30.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 1000box/month
Release date: 2024-11-14

CONTIDE BIOTECH CO.,LTD

Product: GHRP-2 Acetate 158861-67-7
Price: US $0.00/G
Min. Order: 1G
Purity: 99%
Supply Ability: 20kg
Release date: 2024-10-17

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GHRP-2 (FREE PEPTIDE)

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