ChemicalBook > CAS DataBase List > GHRP-2

GHRP-2

Product Name
GHRP-2
CAS No.
158861-67-7
Chemical Name
GHRP-2
Synonyms
GHRP-2;GHRP;CHRP-2;GHRP-2 ACETATE;GHCA;EIF3A;d-ala-β-(2-naphthyl)-d-ala-trp-d-phe-lys amide;-2;-2;p-ERK1
CBNumber
CB1104514
Molecular Formula
C45H55N9O6
Formula Weight
817.97
MOL File
158861-67-7.mol
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GHRP-2 Property

Melting point:
149 - 151°C
Boiling point:
1265.3±65.0 °C(Predicted)
Density 
1.270±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
DMSO (Slightly, Sonicated), Water (Slightly)
form 
lyophilized powder
pka
13.40±0.46(Predicted)
color 
white to beige
Stability:
Hygroscopic
InChI
InChI=1S/C45H55N9O6/c1-27(47)41(56)52-38(24-30-19-20-31-14-6-7-15-32(31)22-30)43(58)50-28(2)42(57)53-39(25-33-26-49-35-17-9-8-16-34(33)35)45(60)54-37(23-29-12-4-3-5-13-29)44(59)51-36(40(48)55)18-10-11-21-46/h3-9,12-17,19-20,22,26-28,36-39,49H,10-11,18,21,23-25,46-47H2,1-2H3,(H2,48,55)(H,50,58)(H,51,59)(H,52,56)(H,53,57)(H,54,60)/t27-,28+,36+,37-,38-,39+/m1/s1
InChIKey
HRNLPPBUBKMZMT-RDRUQFPZSA-N
SMILES
C(N)(=O)[C@H](CCCCN)NC(=O)[C@@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](C)NC(=O)[C@@H](CC1=CC=C2C(=C1)C=CC=C2)NC(=O)[C@@H](C)N
CAS DataBase Reference
158861-67-7(CAS DataBase Reference)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2056
Product name
Pralmorelin trifluoroacetate salt
Purity
≥97% (HPLC)
Packaging
1MG
Price
$162
Updated
2023/01/07
Sigma-Aldrich
Product number
SML2056
Product name
Pralmorelin trifluoroacetate salt
Purity
≥97% (HPLC)
Packaging
5MG
Price
$650
Updated
2023/01/07
Alfa Aesar
Product number
J66029
Product name
Growth Hormone Releasing Peptide-2
Packaging
25mg
Price
$270
Updated
2021/12/16
Alfa Aesar
Product number
J66029
Product name
Growth Hormone Releasing Peptide-2
Packaging
5mg
Price
$113
Updated
2021/12/16
Usbiological
Product number
382744
Product name
EIF3A
Packaging
96Tests
Price
$729
Updated
2021/12/16
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GHRP-2 Chemical Properties,Usage,Production

Description

Pralmorelin (also known as KP-102, GPA-748, GHRP-2, and Growth Hormone Releasing Peptide-2)  is a potent GH secretagogue in development as a diagnostic agent for growth hormone deficiency and for the treatment of pituitary disorders and GH deficiency. It acts as signal molecules that are involved in the control of cell growth and differentiation.

Uses

Growth hormone releasing factor. Pralmorelin is a growth hormone secretagogue that acts on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone release.

Definition

ChEBI: Pralmorelin is an oligopeptide.

benefits

Regulation of blood pressure, increased strength and healing, reduced injury, increased cell rejuvenation, increase in lean muscle mass and stronger bones.

Biochem/physiol Actions

Pralmorelin, also known as Growth hormone-releasing peptide 2 or GHRP-2, is an orally-active, synthetic peptide analogue of met-enkephalin that acts as a ghrelin/growth hormone secretagogue receptor (GHSR) agonist to selectively stimulate the ghrelin receptor and cause growth hormone release. Pralmorelin (GHRP-2) has been used clinically for the assessment of growth hormone deficiency (GHD), It has also been shown to have anti-inflammatory activity.

Mechanism of action

GHRP-2 is an agonist of ghrelin, a gut peptide and also known as “the hunger hormone”, which binds to the growth hormone secretagogue receptor. Pralmorelin works to enhance natural growth hormone production in two ways. First, the GHRP-2 intensifies the natural growth hormone releasing signal, resulting in a substantial secretion of growth hormone. Second, it suppresses a hormone in the body called somatostatin, also known as growth hormone inhibiting hormone (GHIH). Somatostatin generates the body to decrease its natural growth hormone production. By restricting the activity of somatostatin, GHRP-2 can improve growth hormone creation, resulting in increased natural growth hormone levels. GHRP-2 also activates ghrelin, a peptide hormone produced in the gastrointestinal system, which has strong effects on growth hormone production and appetite.

Side effects

No side effects or toxicities were observed. Thus, GHRP-2 is well tolerated and can stimulate GH secretion. Formulations or routes of administration that allow for a longer duration of action will likely be needed to use GHRP-2 in therapy[1].

References

[1] V Mericq. “Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children.” Journal of Clinical Endocrinology & Metabolism 83 7 (1998): 2355–60.

GHRP-2 Preparation Products And Raw materials

Raw materials

Preparation Products

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GHRP-2 Suppliers

Australia 1 China 253 Europe 1 France 1 Germany 2 India 2 South Korea 1 Switzerland 1 The Netherlands 1 United States 19 Global 282
Alabiochem Tech.Co., Ltd.
Tel
512-58900862 400-0707518
Fax
0086-512-56765862
Email
sales@alabiochem.com
Country
China
ProdList
967
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Fax
0551-65326641
Email
info@cellmano.com
Country
China
ProdList
1011
Advantage
55
Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
+86 (21) 5895-8628
Email
sales@uhnshanghai.com
Country
China
ProdList
977
Advantage
58
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4526
Advantage
56
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View Lastest Price from GHRP-2 manufacturers

Shanghai Affida new material science and technology center
Product
GHRP-2 158861-67-7
Price
US $0.00-0.00/box
Min. Order
1box
Purity
99
Supply Ability
20000box
Release date
2024-05-28
Huaian Banting Trading Co., Ltd.
Product
GHRP-2 Acetate 158861-67-7
Price
US $30.00/box
Min. Order
1box
Purity
99%
Supply Ability
1000box/month
Release date
2024-11-14
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
GHRP-2 Acetate 158861-67-7
Price
US $40.00/box
Min. Order
1box
Purity
99%
Supply Ability
5000boxes
Release date
2024-05-11

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