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Mubritinib

Product Name
Mubritinib
CAS No.
366017-09-6
Chemical Name
Mubritinib
Synonyms
CS-522;TAK 165;MUBRITINIB;TAK165;TAK-165;Mubritinib(TAK 165);Mubritinib USP/EP/BP;(E)-1-(4-(4-((2-(4-(trifluoromethyl)styryl)oxazol-4-yl)methoxy)phenyl)butyl)-1H-1,2,3-triazole;(E)-4-((4-(4-(1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole;1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole;1H-1,2,3-Triazole, 1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-
CBNumber
CB21011746
Molecular Formula
C25H23F3N4O2
Formula Weight
468.47
MOL File
366017-09-6.mol
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Mubritinib Property

Melting point:
158.0 to 162.0 °C
Boiling point:
620.9±65.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO : 50 mg/mL (106.73 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
pka
1.45±0.10(Predicted)
form 
powder to crystal
color 
White to Gray to Brown
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Safety

HS Code 
2934.99.4400
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1312
Product name
Mubritinib
Purity
≥98% (HPLC)
Packaging
5MG
Price
$74.1
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1312
Product name
Mubritinib
Purity
≥98% (HPLC)
Packaging
25MG
Price
$289
Updated
2024/03/01
TCI Chemical
Product number
M3058
Product name
Mubritinib
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$185
Updated
2024/03/01
TCI Chemical
Product number
M3058
Product name
Mubritinib
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$552
Updated
2024/03/01
Cayman Chemical
Product number
12096
Product name
Mubritinib
Purity
≥98%
Packaging
5mg
Price
$39
Updated
2024/03/01
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Mubritinib Chemical Properties,Usage,Production

Uses

Treatment of cancer.

Uses

Mubritinib is used in selective targeting of CTNNB1-, KRAS-or MYC-driven human cancer cell growth by combinations of existing drugs

Biological Activity

Potent, irreversible human epithelial growth factor receptor 2 (ErbB2) inhibitor (IC 50 = 6 nM) that displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. Exhibits potent antiproliferative effects in ErbB2-overexpressing cancer cell lines (IC 50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth in vivo .

storage

Store at +4°C

Mubritinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Mubritinib Suppliers

Americas 1 China 118 Europe 2 Germany 1 India 2 Japan 1 United Kingdom 4 United States 21 Global 150
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View Lastest Price from Mubritinib manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Mubritinib 366017-09-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Mubritinib 366017-09-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Dideu Industries Group Limited
Product
Mubritinib 366017-09-6
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-07-06

366017-09-6, MubritinibRelated Search:

2-Methoxyethanol tert-Butylchlorodiphenylsilane Anisole Nizatidine Dasatinib monohydrate PHENYL VALERATE VINYL PROPIONATE 1,4-Adamantandiol 4-Methoxyphenylacetone (Trifluoromethoxy)benzene Lapatinib Gefitinib Imatinib Pralmorelin Sunitinib Phenylhydrazine Vinyl ester resin Trifluoromethyl

  • MUBRITINIB
  • 1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole
  • TAK 165
  • Mubritinib(TAK 165)
  • CS-522
  • TAK165;TAK-165
  • (E)-1-(4-(4-((2-(4-(trifluoromethyl)styryl)oxazol-4-yl)methoxy)phenyl)butyl)-1H-1,2,3-triazole
  • 1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole Mubritinib (TAK 165)
  • Mubritinib 1-(4-(4-((2-((1E)-2-(4-(Trifluoromethyl)phenyl)ethenyl)-4-oxazolyl)methoxy)phenyl)butyl)-1H-1,2,3-triazole
  • (E)-4-((4-(4-(1H-1,2,3-Triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole
  • 1H-1,2,3-Triazole, 1-[4-[4-[[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-4-oxazolyl]methoxy]phenyl]butyl]-
  • Mubritinib USP/EP/BP
  • 366017-09-6
  • C25H23F3N4O2
  • Inhibitors