ChemicalBook > CAS DataBase List > K-252B

K-252B

Product Name
K-252B
CAS No.
99570-78-2
Chemical Name
K-252B
Synonyms
K-252B;KT 5556;k-252b solution;K252B READY MADE;Antibiotic K 252b;K-252B, NOCARDIOPSIS SP;K-252B, NOCARDIOPSIS SPECIES;PROTEIN KINASE INHIBITOR K-252B;K252b Antibiotic K 252b KT 5556;(9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid
CBNumber
CB3452783
Molecular Formula
C26H19N3O5
Formula Weight
453.45
MOL File
99570-78-2.mol
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K-252B Property

Boiling point:
769.8±60.0 °C(Predicted)
Density 
1.78±0.1 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 1 mg/ml).
form 
ready-to-use solution
pka
3.33±0.40(Predicted)
color 
White or off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xi
RIDADR 
UN 1993 / PGIII
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11339
Product name
K252b
Purity
≥98%
Packaging
500μg
Price
$195
Updated
2024/03/01
Cayman Chemical
Product number
11339
Product name
K252b
Purity
≥98%
Packaging
1mg
Price
$335
Updated
2024/03/01
TRC
Product number
K000505
Product name
K252b
Packaging
2.5mg
Price
$2180
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
65721
Product name
K252b
Packaging
2.5mg
Price
$3200
Updated
2021/12/16
Biorbyt Ltd
Product number
orb545968
Product name
K252b
Purity
>98%
Packaging
1mg
Price
$554.2
Updated
2021/12/16
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K-252B Chemical Properties,Usage,Production

Description

K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C. However, as this compound does not freely pass through the cell membrane, it is used to inhibit extracellular kinases (ectokinases) of cells in culture. K252b inhibits receptor-mediated degranulation from basophil-like RBL-2H3 cells (IC50 = 0.5 μg/ml) and human basophils. This extracellular inhibitor is also used in comparison studies with the closely related, cell-permeable inhibitor K252a, particularly in studies of neuronal differentiation.

Chemical Properties

Yellow solid

Uses

K 252b, is an antibiotics, and a known protein tyrosine kinase inhibitor. It has been also shown to inhibit the trophic activity of brain-derived neurotrophic factor on dopaminergic (DAergic) neurons and nerve growth factor on basal forebrain cholinergic neurons.

Uses

K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. K252A exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. While K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).

References

1) Kase et al. (1987), K252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436 2) Makino et al. (2012), Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling; PLoS One, 7 e41049

K-252B Preparation Products And Raw materials

Raw materials

Preparation Products

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K-252B Suppliers

Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 13675144456
Fax
025-85563444
Email
sean.lv@synzest.com
Country
China
ProdList
11438
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
Advantage
69
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Lynnchem
Tel
86-(0)29-85992781 17792393971
Email
info@lynnchem.com
Country
China
ProdList
4587
Advantage
58
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Aikon International Limited
Tel
025-66113011 18112977050
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
16027
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52693
Advantage
58

99570-78-2, K-252BRelated Search:


  • PROTEIN KINASE INHIBITOR K-252B
  • K-252B
  • K-252B, NOCARDIOPSIS SP
  • K-252B, NOCARDIOPSIS SPECIES
  • K252B READY MADE
  • k-252b solution
  • Antibiotic K 252b
  • KT 5556
  • K252b Antibiotic K 252b KT 5556
  • (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid
  • 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, (9S,10R,12R)-
  • (5S,6R,8R)-6-Hydroxy-5-methyl-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylic acid
  • 99570-78-2
  • BioChemical
  • Antibiotics G-M
  • Antibiotics A to Z
  • Antibiotics
  • antibiotic
  • Antibiotics G-MSerine/Threonine Kinase Biology
  • Antibiotics
  • Antibiotics A to
  • Protein Kinase C (PKC)
  • Serine/Threonine Kinase Inhibitors
  • Protein Kinase