ChemicalBook > CAS DataBase List > K-252B
K-252B
- Product Name
- K-252B
- CAS No.
- 99570-78-2
- Chemical Name
- K-252B
- Synonyms
- K-252B;KT 5556;k-252b solution;K252B READY MADE;Antibiotic K 252b;K-252B, NOCARDIOPSIS SP;K-252B, NOCARDIOPSIS SPECIES;PROTEIN KINASE INHIBITOR K-252B;K252b Antibiotic K 252b KT 5556;(9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid
- CBNumber
- CB3452783
- Molecular Formula
- C26H19N3O5
- Formula Weight
- 453.45
- MOL File
- 99570-78-2.mol
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K-252B Property
- Boiling point:
- 769.8±60.0 °C(Predicted)
- Density
- 1.78±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Soluble in DMSO (up to 1 mg/ml) or in DMF (up to 1 mg/ml).
- form
- ready-to-use solution
- pka
- 3.33±0.40(Predicted)
- color
- White or off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months.
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Safety
- Hazard Codes
- Xi
- RIDADR
- UN 1993 / PGIII
- HS Code
- 29349990
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 11339
- Product name
- K252b
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $195
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 11339
- Product name
- K252b
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $335
- Updated
- 2024/03/01
TRC
- Product number
- K000505
- Product name
- K252b
- Packaging
- 2.5mg
- Price
- $2180
- Updated
- 2021/12/16
Medical Isotopes, Inc.
- Product number
- 65721
- Product name
- K252b
- Packaging
- 2.5mg
- Price
- $3200
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb545968
- Product name
- K252b
- Purity
- >98%
- Packaging
- 1mg
- Price
- $554.2
- Updated
- 2021/12/16
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K-252B Chemical Properties,Usage,Production
Description
K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C. However, as this compound does not freely pass through the cell membrane, it is used to inhibit extracellular kinases (ectokinases) of cells in culture. K252b inhibits receptor-
Chemical Properties
Yellow solid
Uses
K 252b, is an antibiotics, and a known protein tyrosine kinase inhibitor. It has been also shown to inhibit the trophic activity of brain-derived neurotrophic factor on dopaminergic (DAergic) neurons and nerve growth factor on basal forebrain cholinergic neurons.
Uses
K252A is a staurosporine analogue isolated from a Nocardiopsis strain as a potent inhibitor of protein kinase C. K252A exhibits potent antitumour activity but shows no antimicrobial activity in vitro, or in vivo toxicity in rodents. While K252A is a potent inhibitor of Ca2+/calmodulin kinase II, it is also active against other kinases, notably myosin light chain kinase, cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and cGMP-dependent protein kinase (PKG).
References
1) Kase et al. (1987), K252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436 2) Makino et al. (2012), Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling; PLoS One, 7 e41049
K-252B Preparation Products And Raw materials
Raw materials
Preparation Products
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99570-78-2, K-252BRelated Search:
AKOS 213-252
Amberlite 252, Ion Exchange Resin
HC-252
9-CARBAZOLEPROPIONIC ACID
KT5720
1-(1-METHYL-1H-INDOL-4-YL)METHYLAMINE 97
9-ISOPROPYLCARBAZOLE
1,3,5,7,9-Pentaoxa-252, 452,652,852-tetraplumbacyclotridec-11 -ene-10,13-dione, (Z)-
POTASSIUM NITRATE EXTRA PURE, B. P.,FCC, E 252
C.I. Acid Red 252
NSC 252
PROTEIN KINASE INHIBITOR K-252A FROM NOCARDIOPSIS SP.)
K-252C
K-252B
CARBAZOL-9-YL-METHANOL
11,12-Dihydroindolo[2,3-a]carbazole
Hydrochlorofluorocarbon-252 (HCFC-252)
GP120 (252-272) (1)