Flavin adenine dinucleotide disodium salt

Product Name: Flavin adenine dinucleotide disodium salt
CAS No.: 84366-81-4
Chemical Name: Flavin adenine dinucleotide disodium salt
Synonyms: FAD;flavin adenine dinucleotide sodium;FAD Disodium Salt Hydrate;FLAVINE ADENINE DINUCLEOTIDE DISODIUM SALT;FACD;FANCD;FAD-N;FAD-NA2;FAD 2NA;FAD/FAD-Na2
CBNumber: CB4725259
Molecular Formula: C27H34N9NaO15P2
Formula Weight: 809.55
MOL File: 84366-81-4.mol

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Flavin adenine dinucleotide disodium salt Property

Melting point:: >203°C (dec.)
storage temp.: 2-8°C
solubility: Methanol (Slightly, Heated), Water (Slightly)
form: Powder
color: yellow to orange-brown
Water Solubility: 5 g/L
Merck: 14,4091
BRN: 5326842
Stability:: Hygroscopic
InChI: InChI=1/C27H33N9O15P2.Na.H/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36;;/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43);;/t14-,15+,16+,19-,20+,21+,26+;;/s3
InChIKey: PGEPWKYNISSNIQ-JQOOTDDSNA-N
SMILES: C(N1C2=CC(C)=C(C)C=C2N=C2C(NC(=O)N=C12)=O)[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@@H]1[C@H]([C@@H](O)[C@H](N2C=NC3=C(N=CN=C23)N)O1)O.[NaH] |&1:19,21,23,36,37,38,40,r|
CAS DataBase Reference: 84366-81-4(CAS DataBase Reference)

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Safety

Safety Statements: 24/25-22
WGK Germany: 3
RTECS: AU7470000
F: 8-10-21
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F6625
Product name: Flavin adenine dinucleotide disodium salt hydrate
Purity: ≥95% (HPLC), powder
Packaging: 10mg
Price: $68.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: F6625
Product name: Flavin adenine dinucleotide disodium salt hydrate
Purity: ≥95% (HPLC), powder
Packaging: 1g
Price: $697
Updated: 2024/03/01

TCI Chemical

Product number: F0014
Product name: Flavin Adenine Dinucleotide Disodium Salt Hydrate
Purity: >94.0%(HPLC)
Packaging: 1g
Price: $210
Updated: 2021/12/16

TCI Chemical

Product number: F0014
Product name: Flavin Adenine Dinucleotide Disodium Salt Hydrate
Purity: >94.0%(HPLC)
Packaging: 100mg
Price: $44
Updated: 2021/12/16

Alfa Aesar

Product number: A14495
Product name: Flavin adenine dinucleotide disodium salt hydrate, 94% (dry wt.), water <10%
Packaging: 100mg
Price: $50.8
Updated: 2021/12/16

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Flavin adenine dinucleotide disodium salt Chemical Properties,Usage,Production

Description

Flavin Adenine Dinucleotide Disodium Salt hydrate is an adenine-containing enzymatic redox cofactor. Also known as flavin cofactors and is critical electron transporter in living systems. FAD has been used as a predominant fluorophore to study unstained eosinophils, which exhibit autofluorescence compared to other leucocytes.

Chemical Properties

yellow-orange powder

Uses

The prosthetic group of certain flavoproteins including D-amino acid oxidase, glucose oxidase, glycine oxidase, fumaric hydrogenase, histaminase, and xanthine oxidase. Riboflavin kinase tumor necrosis factor receptor 1 NADPH oxidase.

Uses

Used as a redox cofactor (electron carrier) for flavoproteins including succinate dehydrogenase (complex), alpha-ketoglutarate dehydrogenase, apoptosis-inducing factor 2 (AIF-M2) , AMID), folate/FAD-dependent tRNA methyltransferase, and N-hydroxylated flavoprotein monooxygenase.

Definition

ChEBI: Flavin adenine dinucleotide disodium is a flavin nucleotide.

Biological Activity

Flavin adenine dinucleotide (FAD) disodium salt is a redox cofactor, a prosthetic group of proteins, involved in several important enzymatic reactions during metabolism.

in vitro

Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10 -3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry.

in vivo

With Flavin adenine dinucleotide (2 mg/kg), the chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT) is significantly cancelled. Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine.

Purification Methods

Small quantities of FAD are purified by paper chromatography using tert-butyl alcohol/water, cutting out the main spot and eluting with water. Larger amounts can be precipitated from water as the uranyl complex by adding a slight excess of uranyl acetate to a solution at pH 6.0, dropwise and with gentle stirring. The solution is set aside overnight in the cold, and the precipitate is centrifuged off, washed with small portions of cold EtOH, then with cold peroxide-free diethyl ether. It is dried in the dark under vacuum over P2O5 at 50-60o. The uranyl complex is suspended in water, and, after adding sufficient 0.01M NaOH to adjust the pH to 7, the precipitate of uranyl hydroxide is removed by centrifugation [Huennekens & Felton Methods Enzymol 3 954 1957]. It can also be crystallised from water. It should be kept in the dark. More recently it was purified by elution from a DEAE-cellulose (Whatman DE 23) column with 0.1M phosphate buffer pH 7, and the purity was checked by TLC. [Holt & Cotton, J Am Chem Soc 109 1841 1987, Beilstein 26 III/IV 3632.]

Flavin adenine dinucleotide disodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Flavin adenine dinucleotide disodium salt Suppliers

Belgium 1 Canada 1 China 188 Europe 3 France 2 Germany 5 India 6 Japan 4 Poland 1 Switzerland 4 United Kingdom 4 United States 22 USA 1 Global 242

Shenzhen Hygieia Biotechnology Co., Ltd

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View Lastest Price from Flavin adenine dinucleotide disodium salt manufacturers

Hangzhou Meiya Pharmaceutical Co Ltd

Product: Flavin Adenine Dinucleotide Sodium (FAD) 84366-81-4
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥99.0%
Supply Ability: 1 ton
Release date: 2024-02-07

Hebei Duling International Trade Co. LTD

Product: Flavin adenine dinucleotide disodium salt hydrate(FAD) 84366-81-4
Price: US $100.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 100 tons
Release date: 2022-09-30

Hebei Kingfiner Technology Development Co. , Ltd.

Product: Flavin adenine dinucleotide disodium salt 84366-81-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 50000kg
Release date: 2024-01-04

84366-81-4, Flavin adenine dinucleotide disodium saltRelated Search:

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Flavin adenine dinucleotide disodium salt hydrate, 94%(dry wt.), water <10%

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Flavin adenine dinucleotide disodium salt hydrate, 94% (dry

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Flavin adenine dinucleotide sodium salt

FAD-2Na >93%

95% (HPLC), powder

(((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl)methoxy)(((((2R,3S,4S)-5-(7,8-dimethyl-2,4-dioxo-2H,3H,4H,10H-benzo[g]pteridin-10-yl)-2,3,4-trihydroxypentyl)oxy)(hydroxy)phosphoryl)oxy)phosphinic acid Disodium Salt

Flavin Adenine Dinucleotide Sodium (FAD)

FlavinadeninedinucleotidedisodiumFlavinadeninedinucleotidedisodium

Flavine adenine dinucleotide disodium salt,FAN

Flavine adenine dinucleotide disodium salt,FAD

84366-81-4

C27H31N9Na2O15P2

C27H31N9Na2O15P2xH2O

C27H31N9O15P22NaH2O

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