D-α-Tocopherol succinate

ChemicalBook > CAS DataBase List > D-α-Tocopherol succinate

D-α-Tocopherol succinate

Product Name: D-α-Tocopherol succinate
CAS No.: 4345-03-3
Chemical Name: D-α-Tocopherol succinate
Synonyms: VE;VITAMIN E SUCCINATE;VES;TOCOPHEROL SUCCINATE;α-Tocopheryl Succinate;D-A-TOCOPHEROL SUCCINATE;ALPHA-TOCOPHERYL SUCCINATE;D-alpha-Tocopheryl;D-ALPHA-TOCOPHERYL SUCCINATE;D-ALPHA-TOCOPHEROL SUCCINATE
CBNumber: CB8483476
Molecular Formula: C33H54O5
Formula Weight: 530.78
MOL File: 4345-03-3.mol

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D-α-Tocopherol succinate Property

Melting point:: ~76 °C(lit.)
Boiling point:: 625.8±55.0 °C(Predicted)
Density: 1.002±0.06 g/cm3(Predicted)
vapor pressure: 0Pa at 20℃
storage temp.: -20°C
solubility: Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol.
pka: 4.35±0.17(Predicted)
color: White or off-white
Odor: Little or no odor
λmax: 286nm(EtOH)(lit.)
Merck: 14,9495
BRN: 4038233
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
LogP: 12 at 25℃
CAS DataBase Reference: 4345-03-3(CAS DataBase Reference)
EPA Substance Registry System: D-.alpha.-Tocopheryl acid succinate (4345-03-3)

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Safety

WGK Germany: 1
RTECS: EJ9984000
F: 8-10-23
HS Code: 2936280000
Toxicity: LD50 oral in rat: > 7gm/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T3126
Product name: D-α-Tocopherol succinate
Purity: semisynthetic, 1210?IU/g
Packaging: 5G
Price: $34.32
Updated: 2024/03/01

Sigma-Aldrich

Product number: T3126
Product name: D-α-Tocopherol succinate
Purity: semisynthetic, 1210?IU/g
Packaging: 25G
Price: $58.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: T3126
Product name: D-α-Tocopherol succinate
Purity: semisynthetic, 1210?IU/g
Packaging: 100G
Price: $265.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: 95255
Product name: D-α-Tocopherol succinate
Purity: BioXtra, ≥98.0% (HPLC)
Packaging: 100MG
Price: $313
Updated: 2024/03/01

Sigma-Aldrich

Product number: 47782
Product name: D-α-Tocopherol succinate
Purity: analytical standard
Packaging: 100MG
Price: $36
Updated: 2024/03/01

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D-α-Tocopherol succinate Chemical Properties,Usage,Production

Description

Tocopherol succinate (4345-03-3) is a potent antioxidant. Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2?Tocopherol succinate induces apoptosis in human gastric cancer cells3?and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14. Induces apoptosis in neuroblastoma cells.5

Chemical Properties

Off-White to Pale Yellow Solid

Uses

A potent antioxidant tocopherol

Uses

A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.

Definition

ChEBI: Tocopherol succinate is a tocol and a hemisuccinate.

General Description

White powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Vitamin E succinate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Fire Hazard

Flash point data for Vitamin E succinate are not available; however, Vitamin E succinate is probably combustible.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Tocopherol exhibits antioxidant property by protecting the cells and membranes from oxidative stress. In plants, high levels of α-tocopherol leads to plant stress tolerance whereas low levels is associated with oxidative stress. In humans, tocopherol prevents cancer, premature aging, atherosclerosis, arthritis caused due to free radicals. Vitamin E succinate (VES) is an anti-tumor analog of vitamin E.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

References

1) Singh?et al. (2010),?Alpha-tocopherol succinate protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor; Int. J. Radiation Biol.,?86?12 2) Singh?et al. (2009),?Tocopherol succinate: a promising radiation countermeasure; Immunopharmacol.,?9?1423 3) Wu?et al. (2004),?c-Jun N-terminal kinase is required for vitamin E succinate-induced apoptosis in human gastric cancer cells; J. Gastroenterol.,?10?1110 4) Stapelberg?et al. (2004),?alpha-Tocopheryl succinate inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors; Biochem. Biophys. Res. Commun.,?318?636 5) Swettenham?et al. (2005),?Alpha-tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system; J. Neurochem.,?94?1448

D-α-Tocopherol succinate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from D-α-Tocopherol succinate manufacturers

Hebei Kingfiner Technology Development Co.Ltd

Product: D-α-Tocopherol succinate 4345-03-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 50000kg
Release date: 2024-05-24

Hebei Guanlang Biotechnology Co., Ltd.

Product: Vitamin E succinate 4345-03-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-09-09

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Tocopheryl Succinate 4345-03-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.7%
Supply Ability: 200000kg
Release date: 2024-04-25

4345-03-3, D-α-Tocopherol succinateRelated Search:

Tocopheryl acetate DL-α-Tocopherol Vitamin A palmitate Vitamin D3 Menadione Cocarboxylase Vitamin A Ascorbic Acid Vitamin E 6alpha-Methylprednisolone sodium succinate Diethylstilbestrol Tocopherol D-alpha-Tocopheryl acetate Vitamin E calcium succinate n-Propyl Dioxepin VitaMin D4 Vitamin E Thiamine chloride

1210IU D-α-Tocopherol succinate,vitamin E succinate 1185IU D-α-Tocopherol succinate,vitamin E succinate

(+)-α-TOCOPHEROL ACID SUCCINATE

D-α-Tocopheryl succinate, Ph. Eur.

[2theta-[2theta(4theta,8theta)]]-cyl)-2h-1-benzopyran-6-yl]este

alpha-tocopherol,succinate

alpha-tocopherolhemisuccinate

butanedioicacid,mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltride

butanedioicacid,mono[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltride

mono[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]ester,[2R-Butanedioicacid

succinicacid,mono(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chroma

VitamineEsuccinate

vitaminehemisuccinate

TOCOPHEROL SUCCINATE

VITAMIN E SUCCINATE

VITAMIN E ACID SUCCINATE

VES

A-TOCOPHEROL ACID SUCCINATE

DL-ALPHA-TOCOPHEROL SUCCINATE

D-ALPHA-TOCOPHERYL SUCCINATE

D-ALPHA-TOCOPHERYL ACID SUCCINATE

D-ALPHA-TOCOPHEROL ACID SUCCINATE

D-ALPHA-TOCOPHEROL SUCCINATE

D-A-TOCOPHERYL ACID SUCCINATE

(+)-A-TOCOPHEROL ACID SUCCINATE FROM

-2,5,7,8-tetramethyl-2-((4R,8R)

-4,8,12-trimethyltridecyl)

4-Oxo-4-(((R)

chroman-6-yl)

ALPHA-TOCOPHERYL ACID SUCCINATE

ALPHA-TOCOPHERYL SUCCINATE

(+)-ALPHA-TOCOPHEROL ACID SUCCINATE

(+)-nyl)este

(2r-(2r*(4r*,8r*)))-cyl)-2h-1-benzopyran-6-yl)este

D-α-Tocopherol succinate

(+)-A-tocopherol acid succinate from*natural A-to

alpha-tocopheryl hydrogen succinate

D-a-Tocopherol acid Succinate

Solid vitamin E-Natural vitamin E Succinate

4-oxo-4-[[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl]oxy]butanoic acid

a-Tocopheryl acid succinate

Butanedioic acid, mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1- benzopyran-6-yl) ester, (2R-(2R*(4R*,8R*)))

Succinic acid, mono(2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl) ester, (+)

4-[[(2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-1-benzopyran]-6-yloxy]-4-oxobutanoic acid

Succinic acid hydrogen 1-[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl] ester

α-Tocopherol acidic succinate

D-alpha-Tocopheryl acid succinate,99+%

Vitamin E succinat (d-alpha-tocopheryl hydrogen succinat)

Alpha Tocopheryl Acid Succinate (250 mg) (Vitamin E Succinate)

VITAMIN E SUCCINATE(TOCOPHEROL SUCCINATE)(P)

(+)-2,5,7,8-TetraMethyl-2-(4,8,12-triMethyltridecyl)-6-chroManol Hydrogen Succinate

Butanedioic Acid 1-[(2R)-3,4-Dihydro-2,5,7,8-tetraMethyl-2-[(4R,8R)-4,8,12-triMethyltridecyl]-2H-1-benzopyran-6-yl] Ester

Covitol 1210

CV 104

d-α-Tocopheryl Acid Succinate

VitaMin E d-α-Tocosuccinate

Tocopheryl Acid Succinate, a

RRR-α-Tocopheryl hydrogen succinate