D-alpha-Tocopheryl acetate
Description References- Product Name
- D-alpha-Tocopheryl acetate
- CAS No.
- 58-95-7
- Chemical Name
- D-alpha-Tocopheryl acetate
- Synonyms
- D-α-Tocopheryl acetate;D-ALPHA-TOCOPHEROL ACETATE;Evipherol;dl-alpha-tocopheryl;α-Tocopherol acetate;D-A-TOCOPHERYL ACETATE;D-α-Tocopherol Acetate;D-alpha-Tocopheryl acetate,98%;Econ;Gevex
- CBNumber
- CB5241875
- Molecular Formula
- C31H52O3
- Formula Weight
- 472.74
- MOL File
- 58-95-7.mol
D-alpha-Tocopheryl acetate Property
- Melting point:
- ~25 °C(lit.)
- alpha
- 3 º (c=2, in ethanol 25 ºC)
- Boiling point:
- 224 °C0.3 mm Hg(lit.)
- Density
- 0.953 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.496(lit.)
- Flash point:
- >230 °F
- storage temp.
- room temp
- solubility
- Practically insoluble in water, freely soluble in acetone, in anhydrous ethanol and in fatty oils, soluble in ethanol (96 per cent).
- form
- oil or semi-solid
- color
- yellow
- Odor
- cryst., odorless
- biological source
- plant
- Water Solubility
- <0.1 g/100 mL at 17 ºC
- Merck
- 14,9495
- Specific Activity
- ~1360IU/g
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- Cosmetics Ingredients Functions
- ANTIOXIDANT
SKIN CONDITIONING - InChI
- 1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1
- InChIKey
- ZAKOWWREFLAJOT-CEFNRUSXSA-N
- SMILES
- CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1
- LogP
- 12.260 (est)
- CAS DataBase Reference
- 58-95-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Vitamin e acetate(58-95-7)
- EPA Substance Registry System
- D-.alpha.-Tocopheryl acetate (58-95-7)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 1
- RTECS
- GP8280000
- TSCA
- TSCA listed
- HS Code
- 29362800
- Storage Class
- 10 - Combustible liquids
- Hazard Classifications
- Aquatic Chronic 4
N-Bromosuccinimide Price
- Product number
- T1157
- Product name
- (+)-α-Tocopherol acetate
- Purity
- BioReagent, suitable for insect cell culture, ~1360 IU/g
- Packaging
- 1g
- Price
- $22.4
- Updated
- 2025/07/31
- Product number
- T1157
- Product name
- (+)-α-Tocopherol acetate
- Purity
- BioReagent, suitable for insect cell culture, ~1360 IU/g
- Packaging
- 10g
- Price
- $66.7
- Updated
- 2025/07/31
- Product number
- T2322
- Product name
- D-alpha-Tocopherol Acetate
- Purity
- >96.0%(GC)
- Packaging
- 25g
- Price
- $154
- Updated
- 2025/07/31
- Product number
- T3001
- Product name
- (+)-α-Tocopherol acetate
- Purity
- oil or semi-solid, ~1360 IU/g, semisynthetic
- Packaging
- 10g
- Price
- $95.55
- Updated
- 2025/07/31
- Product number
- T3001
- Product name
- (+)-α-Tocopherol acetate
- Purity
- oil or semi-solid, ~1360 IU/g, semisynthetic
- Packaging
- 25g
- Price
- $206.57
- Updated
- 2025/07/31
D-alpha-Tocopheryl acetate Chemical Properties,Usage,Production
Description
D-alpha-tocopheryl acetate is a natural form of vitamin E and it is stable in terms of shelf life. It is probably the best form for people actively trying to prevent heart disease. It is used in the dietary and clinical supplementations.
References
[1] Jack Challem, User’s Guide to Nutritional Supplements, 2003
[2] M. K. Horwitt, Relative biological values of d-alpha-tocopheryl acetate and all-rac-alpha-tocopheryl acetate in man, The American Society for Clinical Nutrition, 1980, vol. 33, 1856-1860
Chemical Properties
off-white crystalline solid
Uses
Used in prevention and treatment of vitamin E deficiencies.
Uses
α-Tocopherol acetate is the most bioactive of the naturally occurring forms of Vitamin E. Richest sources are green vegetables, grains, and oils, particularly palm, safflower and sunflower oils.
Uses
(+)-α-Tocopherol acetate has been used:
- as a component of growth medium for retinal cell lines
- as an external standard in high performance liquid chromatography (HPLC) to study its composition in leafy vegetables
- in the preparation of trans-resveratrol-encapsulated lipid nanocarriers (R-nano)
Definition
ChEBI: Alpha-Tocopherol acetate is a tocol.
General Description
Odorless off-white crystals. Darkens at 401° F.
Air & Water Reactions
D-alpha-Tocopheryl acetate may be sensitive to prolonged exposure to light and air. . Insoluble in water.
Reactivity Profile
An ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Fire Hazard
Flash point data for D-alpha-Tocopheryl acetate are not available. D-alpha-Tocopheryl acetate is probably combustible.
Biochem/physiol Actions
α-Tocopherol acetate or vitamin E-acetate has antioxidant properties and reduces lipid peroxidation. However, vitamin E acetate on pyrolysis leads to the generation of carcinogens like alkenes and benzenes.
Contact allergens
Tocopherol and tocopheryl acetate are used mainly as antioxidants. Tocopheryl acetate, an ester of tocopherol (vitamin E), can induce allergic contact dermatitis.
Safety Profile
When heated to decomposition it emits acrid smoke and irritating fumes.
Synthesis
A method of preparing vitamin E acetate, characterized in that it comprises the steps of:
(1) add 2,3,5-trimethylhydroquinone and catalyst composed of concentrated sulfuric acid, copper sulfate, tin chloride to the reaction solvent, stir until the material is dissolved, under the protection of N2, the temperature is controlled at 30-33??C, isophytol is added dropwise in 3-3.5h, dropwise addition is completed, the temperature is raised to 62-66??C, the reaction is held for 2.5h, the reaction is completed, the solution is divided, and the solvent is recovered by decompressed distillation, the reaction solution is Wash, extract vitamin E, deionized water washing until the solution pH is 7, wherein the mass ratio of isophytol to 2,3,5-trimethylhydroquinone is 2-2.5:1, the mass ratio of copper sulfate to 2,3,5-trimethylhydroquinone is 0.045-0.05:1, the mass ratio of stannic chloride to 2,3,5-trimethylhydroquinone is 0.006-0.012:1, the mass ratio of concentrated sulfuric acid to 2,3,5-trimethylhydroquinone is 0.006-0.012:1, the mass ratio of concentrated sulfuric acid to 2,3,5-trimethylhydroquinone is 0.006-0.012:1. 3,5-trimethylhydroquinone in a mass ratio of 0.2-0.4:1;
(2) to the vitamin E layer after washing in step (2) add acetic anhydride and sodium borohydride, N2 protection, heating to 126-130 ?? C esterification reaction of 3.5h, the end of the reaction, decompression distillation recovery of acetic anhydride, water and 70-80% methanol cross-washing to the washout solution pH 7, washed twice, 50-60 ?? C concentration under reduced pressure, recovery of petroleum ether, concentrated, to obtain acetate vitamin E, wherein, acetic anhydride with 70-80% methanol cross-washed to the washout solution pH 7, washed twice, 50-60 ?? C concentrated under reduced pressure, recovery of petroleum ether, concentrated, to obtain acetate vitamin E. E, wherein the weight ratio of acetic anhydride to 2,3,5-trimethylhydroquinone is 2.3-2.7:1, and the amount of sodium borohydride added is 0.1-0.16% of the mass of acetic anhydride.
D-alpha-Tocopheryl acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from D-alpha-Tocopheryl acetate manufacturers
- Product
- D-alpha-Tocopheryl acetate 58-95-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 5kg
- Purity
- 96%-102
- Supply Ability
- 1000KG
- Release date
- 2025-09-18
- Product
- D-alpha-Tocopheryl acetate 58-95-7
- Price
- US $55.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-11-19
- Product
- D-alpha-Tocopheryl acetate 58-95-7
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-23