Description Reference
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Retinyl acetate

Description Reference
Product Name
Retinyl acetate
CAS No.
127-47-9
Chemical Name
Retinyl acetate
Synonyms
VITAMIN A ACETATE;RETINOL ACETATE;retinyl;VITAMIN A ACETAT;RETINOL ACETATE ALL TRANS;ALL-TRANS-RETINYL ACETATE;Myvak;Myvax;Crystalets;VitaMin A ace
CBNumber
CB4308339
Molecular Formula
C22H32O2
Formula Weight
328.49
MOL File
127-47-9.mol
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Retinyl acetate Property

Melting point:
57-58 °C
Boiling point:
406.22°C (rough estimate)
Density 
1.0474 (rough estimate)
refractive index 
1.547-1.555
Flash point:
14℃
storage temp. 
2-8°C
solubility 
absolute ethanol: 25 mg/mL
form 
solid or viscous liquid
color 
Yellow powder
Odor
Amine like
Water Solubility 
soluble
Sensitive 
Light & Air Sensitive & Hygroscopic
Merck 
14,10013
BRN 
1915439
Stability:
Hygroscopic, Light Sensitive
InChIKey
QGNJRVVDBSJHIZ-QHLGVNSISA-N
LogP
9.4 at 25℃
CAS DataBase Reference
127-47-9(CAS DataBase Reference)
NIST Chemistry Reference
Retinol, acetate(127-47-9)
EPA Substance Registry System
Retinol acetate (127-47-9)
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Safety

Hazard Codes 
Xn,Xi,T,F
Risk Statements 
38-63-36/37/38-53-61-11
Safety Statements 
36/37-45-37/39-26-53-16
RIDADR 
UN1170 - class 3 - PG 2 - Ethanol
WGK Germany 
2
RTECS 
VH6825000
1-8-10
TSCA 
Yes
HS Code 
29362100
Toxicity
LD50 (10 day) orally in mice: 4100 mg/kg (Kamm)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H360May damage fertility or the unborn child

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
V-040
Product name
Retinyl acetate solution
Purity
100?μg/mL in ethanol (with 0.1% (w/v) BHT; degassed), reference material, Cerilliant?
Packaging
1mL
Price
$106
Updated
2024/03/01
Sigma-Aldrich
Product number
46958
Product name
Retinyl acetate
Purity
analytical standard
Packaging
100mg
Price
$143
Updated
2024/03/01
Sigma-Aldrich
Product number
1716002
Product name
Retinyl acetate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
10x0.5g
Price
$410
Updated
2022/05/15
Alfa Aesar
Product number
A16237
Product name
Vitamin A acetate in gelatin, 500,000 I.U./g
Packaging
25g
Price
$35.2
Updated
2021/12/16
Alfa Aesar
Product number
A16237
Product name
Vitamin A acetate in gelatin, 500,000 I.U./g
Packaging
100g
Price
$90
Updated
2021/12/16
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Retinyl acetate Chemical Properties,Usage,Production

Description

Retinyl acetate (retinol acetate, vitamin A acetate,127-47-9) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.

Reference

Volker Bühler, Vademecum for Vitamin Formulations, 2001, ISBN 3-8047-1834-5

Chemical Properties

Crystalline

Uses

vitamin precursor

Uses

Essential micronutrient

Uses

Retinyl acetate has been used:

  • a control diet to study its effect at different developmental periods in fish larvae
  • to study its inhibitory effects on Mycobacterium avium?subspecies?paratuberculosis?(MAP) strains
  • as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk

Definition

ChEBI: Retinyl acetate is an acetate ester. It is functionally related to an all-trans-retinol.

General Description

Retinyl acetate is suitable for use in the retention identification of the analyte when using HPLC and GC. Not intended for use as an activity reference standard. It has been thoroughly evaluated to ensure the utmost quality. Neat, unless otherwise noted. Certificate of Composition provided with the purchase.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications. It acts as a chemopreventive agent. Retinyl acetate also has antineoplastic property.

Safety Profile

Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also VITAMIN A.

Purification Methods

The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]

Retinyl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Retinyl acetate Suppliers

Xi'AnTongZeBiotechCo.,Ltd
Tel
+86-18591971926 +86-18591971926
Email
3516471159@qq.com
Country
China
ProdList
154
Advantage
58
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1998
Advantage
65
Hebei Zhentian Food Additives Co., Ltd.
Tel
0319-5925599 13373390591
Fax
0319 5925599
Email
13933732699@163.com
Country
China
ProdList
901
Advantage
58
Spec-Chem Industry Inc.
Tel
13505162978
Email
sc@specchemind.com
Country
China
ProdList
93
Advantage
58
Hubei wei shi reagent group ltd., company
Tel
027-027-59102966 18717199209
Email
2853877583@qq.com
Country
China
ProdList
5773
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94838
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Wuhan Wei Shunda Technology Development Co., Ltd.
Tel
86-027-88774375
Fax
86-027-88416321
Email
mwmwhot@163.com
Country
China
ProdList
233
Advantage
65
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View Lastest Price from Retinyl acetate manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd
Product
Retinyl acetate 127-47-9
Price
US $10.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
10000ton
Release date
2024-04-25
Hebei Saisier Technology Co., LTD
Product
ALL-TRANS-RETINYL ACETATE 127-47-9
Price
US $6.00/KG
Min. Order
25KG
Purity
MORE THAN 99%
Supply Ability
20000KG/MONTH
Release date
2024-03-27
Henan Fengda Chemical Co., Ltd
Product
Retinyl acetate 127-47-9
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-27

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