Retinyl acetate
- Product Name
- Retinyl acetate
- CAS No.
- 127-47-9
- Chemical Name
- Retinyl acetate
- Synonyms
- VITAMIN A ACETATE;RETINOL ACETATE;retinyl;VITAMIN A ACETAT;RETINOL ACETATE ALL TRANS;ALL-TRANS-RETINYL ACETATE;Myvak;Myvax;Crystalets;VitaMin A ace
- CBNumber
- CB4308339
- Molecular Formula
- C22H32O2
- Formula Weight
- 328.49
- MOL File
- 127-47-9.mol
Retinyl acetate Property
- Melting point:
- 57-58 °C
- Boiling point:
- 406.22°C (rough estimate)
- Density
- 1.0474 (rough estimate)
- refractive index
- 1.547-1.555
- Flash point:
- 14℃
- storage temp.
- 2-8°C
- solubility
- absolute ethanol: 25 mg/mL
- form
- solid or viscous liquid
- color
- Yellow powder
- Odor
- Amine like
- Water Solubility
- soluble
- Sensitive
- Light & Air Sensitive & Hygroscopic
- Merck
- 14,10013
- BRN
- 1915439
- Stability:
- Hygroscopic, Light Sensitive
- InChIKey
- QGNJRVVDBSJHIZ-QHLGVNSISA-N
- LogP
- 9.4 at 25℃
- CAS DataBase Reference
- 127-47-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Retinol, acetate(127-47-9)
- EPA Substance Registry System
- Retinol acetate (127-47-9)
Safety
- Hazard Codes
- Xn,Xi,T,F
- Risk Statements
- 38-63-36/37/38-53-61-11
- Safety Statements
- 36/37-45-37/39-26-53-16
- RIDADR
- UN1170 - class 3 - PG 2 - Ethanol
- WGK Germany
- 2
- RTECS
- VH6825000
- F
- 1-8-10
- TSCA
- Yes
- HS Code
- 29362100
- Toxicity
- LD50 (10 day) orally in mice: 4100 mg/kg (Kamm)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H360May damage fertility or the unborn child
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P201Obtain special instructions before use.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- V-040
- Product name
- Retinyl acetate solution
- Purity
- 100?μg/mL in ethanol (with 0.1% (w/v) BHT; degassed), reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 46958
- Product name
- Retinyl acetate
- Purity
- analytical standard
- Packaging
- 100mg
- Price
- $143
- Updated
- 2024/03/01
- Product number
- 1716002
- Product name
- Retinyl acetate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 10x0.5g
- Price
- $410
- Updated
- 2022/05/15
- Product number
- A16237
- Product name
- Vitamin A acetate in gelatin, 500,000 I.U./g
- Packaging
- 25g
- Price
- $35.2
- Updated
- 2021/12/16
- Product number
- A16237
- Product name
- Vitamin A acetate in gelatin, 500,000 I.U./g
- Packaging
- 100g
- Price
- $90
- Updated
- 2021/12/16
Retinyl acetate Chemical Properties,Usage,Production
Description
Retinyl acetate (retinol acetate, vitamin A acetate,127-47-9) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.
Chemical Properties
Retinyl acetate is a yellow, prism-shaped crystal and a lipid-soluble compound, with better chemical stability than vitamin A. In clinical practice, either vitamin A acetate or its palmitate form is typically dissolved in vegetable oil for administration, where it is hydrolyzed by enzymes in the body to release active vitamin A. The form of vitamin A listed in the Chinese Pharmacopoeia refers to the active vitamin A compound.
Uses
Essential micronutrient
Uses
vitamin precursor
Uses
Retinyl acetate has been used:
- a control diet to study its effect at different developmental periods in fish larvae
- to study its inhibitory effects on Mycobacterium avium?subspecies?paratuberculosis?(MAP) strains
- as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk
Preparation
A method for preparing retinyl acetate the following steps:
Under alkaline conditions, 3-methyl-4-oxo-2-butene-1-yl acetate (referred to as C5 aldehyde ester) and tetraethyl methylene diphosphate undergo a condensation reaction to form an intermediate C6 phosphate (chemical name: 5-(diethyl phosphate)-3-methyl-2,4-hexadiene-1-acetate).
Under alkaline conditions, the C6 phosphate undergoes a transposition reaction. C14 aldehyde (chemical name: 2-methyl-4-(2,6,6-trimethyl-1-cyclohexene-1-yl)-3-butene-1-aldehyde) is then added to undergo a Wittig-Horner condensation reaction, yielding retinyl acetate.
Definition
ChEBI: Retinyl acetate is an acetate ester. It is functionally related to an all-trans-retinol.
General Description
Retinyl acetate is suitable for use in the retention identification of the analyte when using HPLC and GC. Not intended for use as an activity reference standard. It has been thoroughly evaluated to ensure the utmost quality. Neat, unless otherwise noted. Certificate of Composition provided with the purchase.
Flammability and Explosibility
Not classified
Biochem/physiol Actions
Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications. It acts as a chemopreventive agent. Retinyl acetate also has antineoplastic property.
Safety Profile
Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also VITAMIN A.
Purification Methods
The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]
References
[1] Volker Bühler, Vademecum for Vitamin Formulations, 2001, ISBN 3-8047-1834-5
[2] SUNATDA ARAYACHUKEAT Thapakorn T U Supason P Wanichwecharungruang. Retinyl acetate-loaded nanoparticles: Dermal penetration and release of the retinyl acetate[J]. International Journal of Pharmaceutics, 2011, 404 1: Pages 281-288. DOI:10.1016/j.ijpharm.2010.11.019.
[3] HARRISON E H. Lipases and carboxylesterases: possible roles in the hepatic metabolism of retinol.[J]. Annual review of nutrition, 1998, 18: 259-276. DOI:10.1146/annurev.nutr.18.1.259.
[4] GERSTER H. Vitamin A–functions, dietary requirements and safety in humans.[J]. International Journal for Vitamin and Nutrition Research, 1997, 67 2: 71-90.
[5] https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/
Retinyl acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Retinyl acetate manufacturers
- Product
- Retinyl acetate 127-47-9
- Price
- US $99.00-35.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 ton
- Release date
- 2024-05-09
- Product
- Retinyl acetate 127-47-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- ≥99%
- Supply Ability
- 20tons
- Release date
- 2024-05-21
- Product
- ALL-TRANS-RETINYL ACETATE 127-47-9
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-07