ChemicalBook > CAS DataBase List > Retinyl acetate

Retinyl acetate

Product Name: Retinyl acetate
CAS No.: 127-47-9
Chemical Name: Retinyl acetate
Synonyms: VITAMIN A ACETATE;RETINOL ACETATE;retinyl;VITAMIN A ACETAT;RETINOL ACETATE ALL TRANS;ALL-TRANS-RETINYL ACETATE;Myvak;Myvax;Crystalets;VitaMin A ace
CBNumber: CB4308339
Molecular Formula: C22H32O2
Formula Weight: 328.49
MOL File: 127-47-9.mol

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Retinyl acetate Property

Melting point:: 57-58 °C
Boiling point:: 406.22°C (rough estimate)
Density: 1.0474 (rough estimate)
refractive index: 1.547-1.555
Flash point:: 14℃
storage temp.: 2-8°C
solubility: absolute ethanol: 25 mg/mL
form: solid or viscous liquid
color: Yellow powder
Odor: Amine like
biological source: synthetic (organic)
Water Solubility: soluble
Sensitive: Light & Air Sensitive & Hygroscopic
Merck: 14,10013
BRN: 1915439
Specific Activity: 475,000-650,000USP units/g
Stability:: Hygroscopic, Light Sensitive
InChIKey: QGNJRVVDBSJHIZ-QHLGVNSISA-N
LogP: 9.4 at 25℃
CAS DataBase Reference: 127-47-9(CAS DataBase Reference)
NIST Chemistry Reference: Retinol, acetate(127-47-9)
EPA Substance Registry System: Retinol acetate (127-47-9)

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Safety

Hazard Codes: Xn,Xi,T,F
Risk Statements: 38-63-36/37/38-53-61-11
Safety Statements: 36/37-45-37/39-26-53-16
RIDADR: UN1170 - class 3 - PG 2 - Ethanol
WGK Germany: 2
RTECS: VH6825000
F: 1-8-10
TSCA: Yes
HS Code: 29362100
Toxicity: LD50 (10 day) orally in mice: 4100 mg/kg (Kamm)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V-040
Product name: Retinyl acetate solution
Purity: 100?μg/mL in ethanol (with 0.1% (w/v) BHT; degassed), reference material, Cerilliant?
Packaging: 1mL
Price: $108
Updated: 2025/07/31

Sigma-Aldrich

Product number: R0300000
Product name: Retinol acetate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 500 mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: 46958
Product name: Retinyl acetate
Purity: analytical standard
Packaging: 100mg
Price: $138.7
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1716002
Product name: Retinyl acetate
Purity: United States Pharmacopeia (USP) Reference Standard, solution of retinyl acetate (vitamin A) in peanut oil
Packaging: 5x0.5g
Price: $351
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1716002
Product name: Retinyl acetate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 10x0.5g
Price: $410
Updated: 2022/05/15

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Retinyl acetate Chemical Properties,Usage,Production

Description

Retinyl acetate (retinol acetate, vitamin A acetate,127-47-9) is a natural form of vitamin A. It is the acetate ester of retinol. It consists of yellow crystals which are greasy or sticky. It has a mild, characteristic odor. It has potential antineoplastic and chemo-preventive activities. It can be used to fortify food with vitamin A. As vitamin A acetate can induce cell differentiation and inhibit cell proliferation, it is used in skin-conditioning agent.

Chemical Properties

Retinyl acetate is a yellow, prism-shaped crystal and a lipid-soluble compound, with better chemical stability than vitamin A. In clinical practice, either vitamin A acetate or its palmitate form is typically dissolved in vegetable oil for administration, where it is hydrolyzed by enzymes in the body to release active vitamin A. The form of vitamin A listed in the Chinese Pharmacopoeia refers to the active vitamin A compound.

Uses

Essential micronutrient

Uses

vitamin precursor

Uses

Retinyl acetate has been used:

a control diet to study its effect at different developmental periods in fish larvae
to study its inhibitory effects on Mycobacterium avium?subspecies?paratuberculosis?(MAP) strains
as an internal standard in high performance liquid chromatography (HPLC) to quantify vitamin A in fortified milk

Preparation

A method for preparing retinyl acetate the following steps:
Under alkaline conditions, 3-methyl-4-oxo-2-butene-1-yl acetate (referred to as C5 aldehyde ester) and tetraethyl methylene diphosphate undergo a condensation reaction to form an intermediate C6 phosphate (chemical name: 5-(diethyl phosphate)-3-methyl-2,4-hexadiene-1-acetate).
Under alkaline conditions, the C6 phosphate undergoes a transposition reaction. C14 aldehyde (chemical name: 2-methyl-4-(2,6,6-trimethyl-1-cyclohexene-1-yl)-3-butene-1-aldehyde) is then added to undergo a Wittig-Horner condensation reaction, yielding retinyl acetate.

Definition

ChEBI: Retinyl acetate is an acetate ester. It is functionally related to an all-trans-retinol.

General Description

Retinyl acetate is suitable for use in the retention identification of the analyte when using HPLC and GC. Not intended for use as an activity reference standard. It has been thoroughly evaluated to ensure the utmost quality. Neat, unless otherwise noted. Certificate of Composition provided with the purchase.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as required. Retinyl acetate is used in a wide range of biological applications. It acts as a chemopreventive agent. Retinyl acetate also has antineoplastic property.

Safety Profile

Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. See also VITAMIN A.

Purification Methods

The acetate is separated from retinol by column chromatography, then crystallised from MeOH. [Kofler and Rubin Vitamins and Hormones (NY) 18 315 1960 for purification methods]. Store it in the dark, under N2 or Ar, at 0o. [Beilstein 6 IV 4135.]

References

[1] Volker Bühler, Vademecum for Vitamin Formulations, 2001, ISBN 3-8047-1834-5
[2] SUNATDA ARAYACHUKEAT Thapakorn T U Supason P Wanichwecharungruang. Retinyl acetate-loaded nanoparticles: Dermal penetration and release of the retinyl acetate[J]. International Journal of Pharmaceutics, 2011, 404 1: Pages 281-288. DOI:10.1016/j.ijpharm.2010.11.019.
[3] HARRISON E H. Lipases and carboxylesterases: possible roles in the hepatic metabolism of retinol.[J]. Annual review of nutrition, 1998, 18: 259-276. DOI:10.1146/annurev.nutr.18.1.259.
[4] GERSTER H. Vitamin A–functions, dietary requirements and safety in humans.[J]. International Journal for Vitamin and Nutrition Research, 1997, 67 2: 71-90.
[5] https://ods.od.nih.gov/factsheets/VitaminA-HealthProfessional/

Retinyl acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Retinyl acetate Suppliers

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View Lastest Price from Retinyl acetate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Retinyl Acetate 127-47-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-12-02

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Retinyl acetate 127-47-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 500kg/month
Release date: 2021-07-19

Hebei Chuanghai Biotechnology Co., Ltd

Product: Retinyl acetate 127-47-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-25

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(2E,4E,6E,8E)

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nona-2,4,6,8-tetraen-1-yl acetate

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Retinal acetate

Vitamin A Acetate, all trans(Synthetic) 500,000 USP u/g

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3,7-Dimethyl-9-(2,6,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol acetate

All-trans-retinol acetate

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Myvak

Myvax