VitaMin D4
Synthesis in Skin- Product Name
- VitaMin D4
- CAS No.
- 511-28-4
- Chemical Name
- VitaMin D4
- Synonyms
- VITAMIN D;COLECALCIFEROL;CALCIOL;RACUMIN D;Duphafral;Vtamin D4;vitamin D4;VITAMINE D4;OLEOVITAMIN D3;CHOLECALCIFEROLUM
- CBNumber
- CB3104866
- Molecular Formula
- C28H46O
- Formula Weight
- 398.66
- MOL File
- 511-28-4.mol
VitaMin D4 Property
- Melting point:
- 83-86 °C(lit.)
- alpha
- D18 +89.3° (c = 0.47 in acetone)
- Boiling point:
- 504.9±29.0 °C(Predicted)
- Density
- 0.96
- storage temp.
- 2-8°C
- solubility
- Soluble in Chloroform
- form
- Powder
- pka
- 14.74±0.20(Predicted)
- color
- Off-white to light yellow
- Stability:
- Hygroscopic, Temperature Sensitive
- InChIKey
- DIPPFEXMRDPFBK-JPWDPSJFSA-N
- SMILES
- [C@H]1(O)CCC(=C)/C(=C\C=C2/CCC[C@@]3(C)[C@@]/2([H])CC[C@@H]3[C@H](C)CC[C@H](C)C(C)C)/C1
- CAS DataBase Reference
- 511-28-4(CAS DataBase Reference)
Safety
- Hazard Codes
- T+
- Risk Statements
- 24/25-26-48/25
- Safety Statements
- 28-36/37
- RIDADR
- UN 2811 6.1/PG 2
- WGK Germany
- 2
- RTECS
- VS2900000
- F
- 8-10-23
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H330Fatal if inhaled
H372Causes damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P314Get medical advice/attention if you feel unwell.
N-Bromosuccinimide Price
- Product number
- 88815
- Product name
- 22,23-Dihydroergocalciferol
- Purity
- ≥97.0% (HPLC)
- Packaging
- 1mg
- Price
- $281
- Updated
- 2023/01/07
- Product number
- 22471
- Product name
- Vitamin D4
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 22471
- Product name
- Vitamin D4
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $222
- Updated
- 2024/03/01
- Product number
- V680000
- Product name
- VitaminD4
- Packaging
- 1mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- 474334
- Product name
- Vitamin D
- Packaging
- 1mg
- Price
- $918
- Updated
- 2021/12/16
VitaMin D4 Chemical Properties,Usage,Production
Synthesis in Skin
Once vitamin D, enters the circulation, it is transported to the liver where it is hydroxylated to 25-hydroxyvitamin D3 (25-(OH)D3). 25-Hydroxyvitamin D3 is the major circulating form of vitamin D3 and its determination is often used to measure the vitamin D status of a patient. Although 1 ,25-(OH)2D3 has a marked effect on inhibiting proliferation of cultured human fibroblasts and keratinocytes and inducing terminal differentiation of cultured keratinocytes, there is no evidence that a deficiency in this hormone will increase proliferative activity in human skin. Thus, it would appear that 1,25-(OH)D3 is not a major regulator of dermal and epidermal proliferation and differentiation. Despite the fact that 1,25-(OH)2D3 is not a major participant in the regulation of epidermal differentiation, the observations that 1,25-(OH)D3 can inhibit the hyperproliferative activity of epidermal cells in patients with psoriasis is intriguing. It should be noted that patients with psoriasis have a normal metabolism of vitamin D to 25-hydroxyvitamin D and 1 ,25-(OH)2D3.24 Therefore, 1 ,25-(OH)2D3 and its analogs hold promise as unique pharmacologic agents for treating hyperproliFerative disorders of the skin such as psoriasis.
Description
Derived from cholesterol, vitamin D is biosynthesized from its prohormone cholecalciferol (D3), the product of solar ultraviolet irradiation of 7-dehydrocholesterol in the skin. In 1966, it was first recognized that vitamin D must undergo activation via two oxidative metabolic steps. The first oxidation to 25-hydroxycholecalciferol (25(OH)D3: calcifediol; Calderol) occurs in the endoplasmic reticulum of the liver and is catalyzed by vitamin D 25-hydroxylase. This activation step is not regulated by plasma calcium concentrations. The major circulating form (10–80 μg/mL) is 25(OH)D3, which also is the primary storage form of vitamin D.
Chemical Properties
Pale Yellow Oil
Uses
Vitamin D4 is the active analogue of Vitamin D.
Definition
ChEBI: Vitamin D4 is it is present in mushrooms. It has a role as a fungal metabolite. It is a vitamin D and a seco-ergostane.
Biological Functions
Sterol-specific cytoplasmic receptor proteins (vitamin D receptor) mediate the biological action of vitamin D. The active hormone is transported from the cytoplasm to the nucleus via the vitamin D receptor, and as a result of the interaction of the hormone with target genes, a variety of proteins are produced that stimulate the transport of calcium in each of the target tissues Active vitamin D works in concert with PTH to enhance active intestinal absorption of calcium, to stimulate bone resorption, and to prohibit renal excretion of calcium. If serum calcium or 1,25-calcitriol concentrations are elevated, then vitamin D 24-hydroxylase (in renal mitochondria) is activated to oxidize 25(OH)D3 to inactive 24,25-dihydroxy-cholecalciferol and to further oxidize active vitamin D to the inactive 1,24,25-trihydroxylated derivative. Both the 1,24,25-trihydroxylated and the 24,25-dihydroxylated products have been found to suppress PT H secretion as well. The biosynthesis of vitamin D is tightly regulated based on the serum concentrations of calcium, phosphate, PTH, and active vitamin D.
Source
Vitamin D is a 9,10-secosteroid and 6 forms have been identified. The importance of vitamin D in bone (calcium homeostasis) is well established, and vitamin D has been the subject of increased attention in recent years for its role in muscle function, immunology, heart and cardiovascular disease, cancer, and insulin secretion. The vitamin D4 precursor 22,23-dihydroergosterol was present in all mushroom composites. The levels were not correlated with vitamin D4, but differed among species. Enoki mushrooms had a notably higher 22,23-dihydroergosterol content, with an average of 16.5 mg/100g compared to 4.49–8.89 mg/ 100 g in other types of mushrooms.
VitaMin D4 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from VitaMin D4 manufacturers
- Product
- VitaMin D4 511-28-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-03
- Product
- VitaMin D4 511-28-4
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-05-14
- Product
- VITAMIN D3 511-28-4
- Price
- US $9.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 5000kg
- Release date
- 2024-08-21