Nutritional supplement Production method Uses Toxicity Usage limit Chemical properties Hazards & Safety Information
ChemicalBook > CAS DataBase List > D-(+)-Pantothenic acid calcium salt

D-(+)-Pantothenic acid calcium salt

Nutritional supplement Production method Uses Toxicity Usage limit Chemical properties Hazards & Safety Information
Product Name
D-(+)-Pantothenic acid calcium salt
CAS No.
137-08-6
Chemical Name
D-(+)-Pantothenic acid calcium salt
Synonyms
D-caL;pancal;Calpan;(theta)-;Pantholin;NSC 36292;calpanate;panthoject;VITAMIN B5;DL-Calcium
CBNumber
CB3695335
Molecular Formula
C9H17NO5.1/2Ca
Formula Weight
476.53
MOL File
137-08-6.mol
More
Less

D-(+)-Pantothenic acid calcium salt Property

Melting point:
190 °C
alpha 
26.5 º (c=5, in water)
refractive index 
27 ° (C=5, H2O)
Flash point:
145 °C
storage temp. 
2-8°C
solubility 
H2O: 50 mg/mL at 25 °C, clear, nearly colorless
form 
Powder
color 
White or almost white
PH
6.8-7.2 (25℃, 50mg/mL in H2O)
optical activity
[α]20/D +27±2°, c = 5% in H2O
Water Solubility 
Soluble in water.
Sensitive 
Hygroscopic
Merck 
14,7015
BRN 
3769272
Stability:
Stable, but may be moisture or air sensitive. Incompatible with strong acids, strong bases.
InChIKey
FAPWYRCQGJNNSJ-UBKPKTQASA-L
CAS DataBase Reference
137-08-6(CAS DataBase Reference)
EPA Substance Registry System
Calcium pantothenate (137-08-6)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-37/38-41-48
Safety Statements 
24/25-45-36/37/39-26-22
WGK Germany 
1
RTECS 
RU4375000
3-10
TSCA 
Yes
HS Code 
29362400
More
Less

Hazard and Precautionary Statements (GHS)

Signal word
Warning
More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
21210
Product name
D-Pantothenic acid hemicalcium salt
Purity
≥98.0%
Packaging
5g-f
Price
$29.2
Updated
2020/08/18
Sigma-Aldrich
Product number
21210
Product name
D-Pantothenic acid hemicalcium salt
Purity
≥98.0%
Packaging
5 g
Price
$30.2
Updated
2021/03/22
Sigma-Aldrich
Product number
21210
Product name
D-Pantothenic acid hemicalcium salt
Purity
≥98.0%
Packaging
25 g
Price
$51.5
Updated
2021/03/22
Sigma-Aldrich
Product number
21210
Product name
D-Pantothenic acid hemicalcium salt
Purity
≥98.0%
Packaging
100 g
Price
$97.4
Updated
2021/03/22
Sigma-Aldrich
Product number
C0400000
Product name
Calcium pantothenate
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
More
Less

D-(+)-Pantothenic acid calcium salt Chemical Properties,Usage,Production

Nutritional supplement

D-Calcium pantothenate as components of coenzyme A regulates the metabolism of protein, saccharide, and fat, and prevents diseases, which is indispensable substance for growth and development of domesticated creatures and fishes, for fatty synthesis and decomposition. The lack of D-calcium pantothenate would result in the slow growth of poultry and the malfunction of reproduction mechanisms. Therefore, D-calcium pantothenate as a growth factor is used in feed additives. In addition, D-calcium pantothenate is also as food enrichment widely used in food industries, sun as breakfast cereals, beverages, dietetic, and baby foods.
D-Calcium pantothenate has the function of making antibodies and it plays an important role in the fight against pressure to maintain hair, skin and blood health, and also contributes to improving the deficiency and neuritis. Thus, it has broad medical value and has been applied in pharmaceutical industries that single-dose is used for pantothenic acid deficiency, complex of vitamins B and multivitamins are used for vitamin supplement, and other compounds with different components are widely used for gastrointestinal diseases, respiratory diseases, skin diseases, mental inactivity, neurasthenia, and so on.

Production method

Take isobutyraldehyde as raw material; carry out hydroxymethylation, addition reaction, hydrolysis, acidification, lactonization and acylation to derive the final product.
Formaldehyde and anhydrous potassium carbonate are sent into the reaction pot. At 14-20 °C, it is added dropwise of isobutyraldehyde. After the completion of the addition, incubate for stirring reaction for 3h, and then stand at 14-18 °C for 0.5 h to obtain the upper oil-2, 2-dimethyl-3-hydroxypropionaldehyde.
2, 2-dimethyl-3-hydroxypropanal is dissolved in 4 times the water while the sodium cyanide is dissolved in 6 times the water and calcium chloride dissolved in 2 times the water. The above solutions are successively added into the reaction pot. 50% sulfuric acid solution was added under stirring at 60-65 ° C for 6h; then being heated to 80-85 °C for 3h and subject to vacuum concentration to being thick. 95% ethanol was added to precipitate the inorganic salt and filtrate. After the recovery of ethanol through distillation under reduced pressure, collect the fractions of 130-145C (1.33-2.39 Kpa), namely ?-butyrolactone.
Then, β-aminopropionic acid, 5/6 methanol and lime were successively added to the reactor. Raise the temperature to 40 °C, and the reaction was stirred for 2 hours. The reaction mixture was allowed to stand for while before the supernatant was filtered by filtration. The solid residue in the pot was washed with 1/6 methanol and then filtered. The filtrate is placed in another reaction pot, being added of γ-butyrolactone for stirring and dissolving in room temperature for 40 h reaction to generate calcium pantothenate. Stirring with water and cooling to-5-0 °C, and add seed crystal for stirring of 24 hours, filter to obtain the dextro calcium pantothenate.
2/3 the amount of calcium pantothenate and calcium p-pantothenate are thrown into the reaction pot; add methanol and water, heat to 40 °C for stirring dissolving and filter upon being hot. The filtrate is cooled to 15 °C, added of a small amount of calcium L-pantothenate and crystal for 2h. When the specific rotation is up to +6 °-+8 °, separate the crystal, and wash with a small amount of methanol to obtain the L-calcium p-pantothenate (still used for resolution). The remaining 1/3 racemic calcium pantothenate was dissolved in a filtrate of 35-40 ° C, filtered and cooled to 15 ° C. A small amount of calcium p-pantothenate was added and the crystals were incubated for 2 hours. Crystals were separated when the specific rotation was-0.8 °--0.6 °, washed with a small amount of methanol and dried in vacuo to give calcium dextrate.
It is derived through the heating and condensation between calcium β-alanine and α-hydroxy β, β-dimethyl-γ-butyl ester.

Uses

1.    It can be applied to biochemical studies; as the nutrient composition of tissue culture medium. It is clinically used for the treatment of vitamin B deficiency, peripheral neuritis and postoperative colic.
2.    It can be used as food fortifier, also used as infant food with the usage amount of 15~28 mg/kg; it is 2~4mg/kg in the drink.
3.    This product is a vitamin drugs, being an integral part of coenzyme A. In the mixture of calcium pantothenate, only the right-hand body has vitamin activity, participating into the in vivo metabolism of protein, fat and carbohydrate. It can be used for the treatment of vitamin B deficiency and peripheral neuritis, and postoperative colic. Its combined treatment with vitamin C can be used for the treatment of disseminated lupus erythematosus. The lack of calcium pantothenate in human body has the following symptoms: (1) growth arrest, weight loss and sudden death. (2) Skin and hair disorders. (3) Neurological disorders. (4) Digestive disorders, liver dysfunction. (5) Affect the antibody formation. (6) Kidney dysfunction. Every day the body demands 5 mg of calcium pantothenate (calculated based on pantothenic acid). Calcium pantothenate, as a nutritional supplement, can be used for the food processing. In addition to special nutritional food, the usage amount should be below 1% (calculated on calcium) (Japan). Upon the strengthening of the milk powder, the usage amount should be 10 mg/100g. Addition of 0.02% into the Shochu and whiskey can further enhance the flavor. Addition of 0.02% into the honey can prevent the winter crystallization. It can be used for buffering the bitterness of caffeine and saccharin.
4.    It can be used as feed additives, food additives, being in line with Pharmacopoeia USP28/BP2003
5.    It can be used as nutritional supplements, being able to enhance the flavor of shochu whiskey to prevent the crystallization of honey in winter.
6.    It is the precursor product for the biosynthesis of coenzyme A. Because of the easy-deliquescence of pantothenic acid and other unstable properties, it is used of calcium salt as the substitute.

Toxicity

LD50>10 g/kg (rat, oral);
GRAS (FDA, § 182.5212, §184.1212, 2000);

Usage limit

GMP as the limit (FDA &184.1212, 2000);
1% in general food (calculated based on calcium excluding special nutritional supplements; Japan, 1993);

Chemical properties

It appears as white crystalline (methanol), being hygroscopic; it is stable to the light and air with its aqueous solution being weakly alkaline. Its Mp is 195-196 °C (decomposition); Specific rotation [α] 26D + 28.2 ° (5%, water); It is soluble in water and glycerol, being slightly soluble in acetone and ethanol;

Hazards & Safety Information

Category: Toxic substances
Toxicity classification: Low toxicity
Acute toxicity: Oral-rat LD50: 10000 mg/kg; oral-mouse LD50: 10000 mg/kg
Flammability and Hazardous characteristics: Thermal decomposition releases toxic nitrogen oxides
Storage and transport characteristics Treasury: low temperature, ventilated and dry
Fire extinguishing agent:  water, carbon dioxide, dry powder, foam

Chemical Properties

D-(+)-Pantothenic acid calcium salt is white crystalline powder

Originator

Calcium D-Pantothenate,Arocor Holdings Inc.

History

Pantothenic acid (PA), also known as vitamin B5, is essential to all forms of life. Its name is derived from the Greek word pantos that means “everywhere”, which is appropriate for this widely, distributed vitamin.

Uses

D-(+)-Pantothenic acid calcium salt is a member of the B complex vitamins; essential vitamin for the biosynthesis of coenzyme A in mammalian cells. Occurs ubiquitously in all animal and plant tissue. The richest common source is liver, but jelly of the queen bee contains 6 times as much as liver. Rice bran and molasses are other good sources.

Uses

calcium pantothenate is used as an emollient and to enrich creams and lotions in hair care preparations. This is the calcium salt of pantothenic acid found in liver, rice, bran, and molasses. It is also found in large amounts in royal jelly.

Uses

Calcium Pantothenate is a nutrient and dietary supplement which is the calcium chloride double salt of . It is a white powder of bitter taste and has a solubility of 1 g in 3 ml of water. It is used in special dietary foods.

Reactions

Pantothenic acid is a constituent of coenzyme A, which participates in numerous enzyme reactions. CoA was discovered as an essential cofactor for the acetylation of sulfanilamide in the liver and of choline in the brain.

Manufacturing Process

A mixture of 288 g (4 mols) of isobutyraldehyde, 288 g of methanol was cooled to 10°C and 170 g (2 mols) of 36.6% formalin containing 8.5 g (3% based on isobutyraldehyde) of sodium hydroxide was added dropwise over a 55 minute period to produce alpha,alpha-dimethyl-beta-hydroxy-propionaldehyde. The mixture was stirred for an additional 2 hours at 10-15°C and then contacted with acetic acid to neutralize the catalyst. The excess isobutyraldehyde and methanol were stripped off at a kettle temperature of 50°C at 25 mm. To the residual α,α-dimethyl-beta-hydroxypropionaldehyde a mixture of 260 ml of methanol and 2 g (0.75%) sodium cyanide was added and the solution cooled to 10°C before adding 59.4 g (2.2 mols) of hydrogen cyanide dropwise over a 35 minute period to produce α,γ-dihydroxy-β,β- dimethylbutyronitrile. The mixture was stirred at 10°C for one hour period and then contacted with acetic acid to neutralize the catalyst before stripping off the excess methanol to a kettle temperature of 45°C at 18 mm. The crude cyanohydrin was then hydrolysed by heating with 4 mols of concentrated hydrochloric acid at 80°C for 2 hours, then diluting with an equal volume of water and heating at 100°C for an additional 8 hours. The aqueous mixture was extracted continuously with ethylene dichloride. The solvent was removed, and pantolactone (B. P. 131°C/19 mm, M.P. 61-77°C, 96.5% purity by saponification) was obtained by distillation in 71.5% yield based on formaldehyde and 55% efficiency based on isobutyraldehyde.
26 grams of racemic pantolactone (0.2 mol) and 1.1 grams of sodium methoxide (0.02 mol) contained in 30 ml of methanol, were added to 78.8 grams of 1-brucine (0.2 mol) contained in 156 ml of methanol. The resulting mixture was refluxed for 1.5 hours and allowed to stand at room temperature overnight. After centrifuging, washing with methanol and drying, 65.4 grams of D-(-)-pantolactone 1-brucine (62% of theory based upon all of the racemic pantolactone) melting at 203° to 206°C were obtained. Upon chilling the mother liquor, 13.46 grams of additional complex melting at 175° to 177°C were obtained.
D-(-)-Pantolactone was obtained from the complex in the following manner. The 65.4 grams of complex obtained above were treated with 65 ml of chloroform and 5.35 grams of sodium hydroxide contained in 35 ml of water for one hour at room temperature. The aqueous layer was extracted 6 times with 20 ml portions of chloroform in order to remove the brucine. The sodium pantoate contained in the aqueous layer was relactonized by treatment with 11 ml of concentrated hydrochloric acid. Extraction of the crude D-(-)- pantolactone yielded 15.29 grams. This material was then recrystallized from 7 ml of methyl isobutyl ketone and 7 ml hexane thereby yielding 9.77 grams of D-(-)-pantolactone (37% of theory). The αD25 was -44.8°.
Into a vessel equipped with an agitator and reflux condenser are placed approximately 52 parts by weight of α-hydroxy-β,β-di-methyl-γ-butyrolactone, approximately 36 parts by weight of β-alanine, about 40 parts by weight of diethylamine and about 100 parts by weight of anhydrous methanol. The mixture is stirred and refluxed for about 12 hours until the reaction is complete as evidenced by the dissolution of the β-alanine. To this resulting mass is gradually added 8 parts by weight of calcium metal nodules or pellets and refluxing continued until the metal is dissolved. The diethylamine and alcohol are distilled off until the residue becomes viscous. The viscous residue is dried under vacuum at 100°C. The solid residue recovered, as biologically assayed, indicated a 91% yield of calcium pantothenate.

brand name

Calpan (BASF); Pantholin (Lilly).

Therapeutic Function

Vitamin

General Description

The first suggestion for the existance of vitamin B5 came from Carter et al. in 1930; although it was never characterized or isolated. This vitamin is synthesized by most green plants and microorganisms. Excellent sources of the vitamin are liver, egg yolk, whole grains, and fortified ready-to-eat cereals. However, as the original name implies, many foods contain sufficient pantothenic acid to supply dietary needs.
Chemically, pantothenic acid is considered to be aβ-alanine derivative of the asymmetric pantoic acid and thus shows asymmetry. Only the naturally occurring D(+)- stereoisomer (with R configuration) is biologically active and the L(-)-stereoisomer (with S configuration) is inactive. When its carboxylate functional group is attached through an amide linkage with β-mercaptoethylamine, it is known as pantetheine (also spelled pantotheine). The biologically active form of pantothenic acid, CoA, is formed when the terminal alcoholic function of pantetheine is attached to ADP 3'-phosphate.

Clinical Use

The only therapeutic indication for pantothenic acid is intreatment of a known or suspected deficiency of this vitamin.Because of the ubiquitous nature of pantothenic acid, deficiencystates of this vitamin are only seen experimentally byuse of synthetic diets devoid of the vitamin, by use of thevitamin antagonist, ω-methylpantothenic, or both. In a 1991review, Tahiliani and Beinlich described that the mostcommon symptoms associated with pantothenic acid deficiencywere headache, fatigue, and a sensation of weakness.Sleep disturbances and gastrointestinal disturbances, amongothers, were also noted. The most likely setting for pantothenicacid deficiency is in the setting of alcoholism wherea multiple vitamin deficiency exists confounding the exactrole of the pantothenic acid deficiency as compared to theother vitamins. Because a deficiency of a single B vitamin israre, pantothenic acid is commonly formulated in multivitaminor B-complex preparations.

Safety Profile

Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. Mildly toxic by ingestion. A vitamin. See also CALCIUM COMPOUNDS. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

The salt crystallises as needles from MeOH, EtOH or isoPrOH (with 0.5mol of isoPrOH). It is moderately hygroscopic. The S-benzylisothiuronium salt has m 151-152o (149o when crystallised from Me2CO). [Kagan et al. J Am Chem Soc 79 3545 1957, Wilson et al. J Am Chem Soc 76 5177 1954, Stiller & Wiley J Am Chem Soc 63 1239 1941, Beilstein 4 IV 2569.]

More
Less

D-(+)-Pantothenic acid calcium salt Suppliers

Nanjing Jinhao Pharmaceutical Co., Ltd.
Tel
13382796873;13376086365;15851804510
Fax
025-58602884
Email
hjz8008@163.com
Country
China
ProdList
47
Advantage
58
Ningbo biermann pharmaceutical technology co., LTD
Tel
0571-82572971
Email
sunzuqian@bichem.cn
Country
China
ProdList
38
Advantage
58
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852-
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2957
Advantage
58
Jiangyin Ligang 2nd Chemical Co., Ltd.
Tel
0510-86631396
Fax
0510-86638684
Email
82871124@qq.com
Country
China
ProdList
10
Advantage
60
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623;022-89880623
Fax
86(0)22-66880086
Email
sales@tjzxchem.com;sales@tjzxchem.com
Country
China
ProdList
617
Advantage
60
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43496
Advantage
61
More
Less

View Lastest Price from D-(+)-Pantothenic acid calcium salt manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
D-(+)-Pantothenic acid calcium salt 137-08-6
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-16
Hebei Lingding Biological Technology Co., Ltd
Product
D-(+)-Pantothenic acid calcium salt 137-08-6
Price
US $50.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-09-29
Hebei Lingding Biological Technology Co., Ltd
Product
D-(+)-Pantothenic acid calcium salt 137-08-6
Price
US $50.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
9000kg/per week
Release date
2021-09-29

137-08-6, D-(+)-Pantothenic acid calcium saltRelated Search:


  • (+)-PANTOTHENIC ACID CALCIUM SALT
  • PANTOTHENIC ACID CALCIUM SALT
  • (R)-(+)-N-(2,4-DIHYDROXY-3,3-DIMETHYL-1-OXOBUTYL)-BETA-ALANINE HEMICALCIUM SALT
  • (theta)-
  • beta-alanine,n-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,calciumsalt(2:1),
  • N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,calciumsalt(2:1),(R)-.beta.-Alanine
  • N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-alaninecalciumsalt
  • n-(2,4-dihydroxy-3,3-dimethylbutyryl)-beta-alaninecalcium
  • pancal
  • panthoject
  • Pantholin
  • .beta.-Alanine, N-(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl-, calcium salt (2:1)
  • D-CALCIUM PANTOTHENATE USP
  • CALCIUMPANTOTHENATE,FCC
  • CALCIUMPANTOTHENATE,POWDER,USP
  • CALCIUMPANTOTHENATE,ULTRAPURE
  • VITAMIN B5
  • VITAMIN B3/B5
  • Calcium D-(+)-N-(α,γ-dihydroxy-β,β-dimethylbutyryl)-β-alaninate
  • Calcium, bis(pantothenato)- (7CI)
  • Calpan
  • N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-b-alanine calcium
  • NSC 36292
  • Pantothenic acid hemicalcium salt
  • Pantothenic acid, calcium salt (2:1), D- (8CI)
  • Vitamin B5 calcium salt
  • β-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1), (R)-
  • β-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, calcium salt (2:1)
  • Calcium-D-pantothenat
  • CALCIUMPANTOTHENAT
  • (R)-.beta.-Alanine
  • N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt
  • (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-b-alanine hemicalcium salt
  • CALCIUM PANTOTHENATE pure
  • D-Pantothenic acid hemicalcium salt, Calcium D-pantothenate, VitaminB5, (R)-(+)-N-(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine hemicalcium salt
  • CalciuM 3-(2,4-dihydroxy-3,3-diMethylbutanaMido)propanoate
  • CalciuM (R)-3-(2,4-dihydroxy-3,3-diMethylbutanaMido)propanoate
  • CalciuM D-pantothenatealanine heMicalciuM salt
  • d-calcium pantothanate
  • Calcium D-Panthotenate
  • Pantothenic Acid/pantothenate/vitamin B5
  • D-Calcium Panthotenate(Vitamin B5)
  • CALCIUM (+)-PANTOTHENATE
  • CALCIUM PANTOTHENATE
  • CALCIUM D-(+)-PANTOTHENATE
  • CALCIUM D-PANTOTHENATE
  • CALCIUM DEXTRO-ANTOTHENATE
  • D-CALCIUM PANTATHENATE
  • D-CALCIUM PANTHOTENA
  • D-(+)-CALCIUM PANTOTHENATE
  • D-CALCIUM PANTOTHENATE
  • D-VITAMIN B CALCIUM SALT
  • D-PANTOTHENIC ACID, CALCIUM
  • D-PANTOTHENIC ACID CALCIUM SALT
  • D(+)-PANTOTHENIC ACID HEMICALCIUM SALT
  • -Cypermethrin 1-Epimeric Mixture
  • Calcium pantothenate (Vitamin B5
  • D-PANTOTHENIC ACID CALCIUM SALT) in stock GMP Factory