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Menatetrenone

Product Name
Menatetrenone
CAS No.
863-61-6
Chemical Name
Menatetrenone
Synonyms
Vitamin K2;MENAQUINONE;e3100;D00100;Glakay;kaytwo;mk(sub4);k2(sub20);Metetrenone;Vitamin MK-4
CBNumber
CB2471321
Molecular Formula
C31H40O2
Formula Weight
444.65
MOL File
863-61-6.mol
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Menatetrenone Property

Melting point:
350C
Boiling point:
494.59°C (rough estimate)
Density 
1.0461 (rough estimate)
refractive index 
1.5045 (estimate)
Flash point:
2℃
storage temp. 
-20°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Heated)
color 
Light Yellow to Yellow Oil
InChIKey
DKHGMERMDICWDU-GHDNBGIDSA-N
CAS DataBase Reference
863-61-6(CAS DataBase Reference)
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Safety

Safety Statements 
22-24/25
RIDADR 
UN 1648 3 / PGII
WGK Germany 
3
RTECS 
QL9279500
HS Code 
2914699000
Toxicity
LD50 intravenous in dog: > 40mL/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
V9378
Product name
Vitamin K2
Packaging
1g
Price
$409
Updated
2024/03/01
Sigma-Aldrich
Product number
V-031
Product name
Vitamin K2 (MK-4) solution
Purity
100?μg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$129
Updated
2024/03/01
Sigma-Aldrich
Product number
47774
Product name
Menaquinone (K2)
Purity
analyticalstandard
Packaging
100mg
Price
$44.9
Updated
2024/03/01
Cayman Chemical
Product number
18423
Product name
Menaquinone 4
Purity
≥98%
Packaging
100mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
18423
Product name
Menaquinone 4
Purity
≥98%
Packaging
1g
Price
$312
Updated
2024/03/01
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Menatetrenone Chemical Properties,Usage,Production

Description

Menatetrenone (also known as MK-4) is a manaquinone compound and a vitamin K compound which can be used as a hemostatic agent as well as adjunctive therapy for the pain of osteoporosis. It mainly takes effects through modulating the signaling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. It is capable of inhibiting tumor cells growth through inducing apoptosis and cell cycle arrest. It can be produced via the conversion of vitamin K1 inside the body including the testes, pancreas and arterial walls.

Chemical Properties

A yellow crystal is extracted from acetone-ethanol or methanol-chloroform. It has a molecular weight of 580.90 and a melting point of 51-52°C. It is insoluble in water but slightly soluble in oil. It dissolves well in ethanol, ether, acetone, benzene, chloroform, and other organic solvents. However, its solubility is slightly lower than that of vitamin K1. It decomposes when exposed to strong acid, oxidants, alkalis, and light.

Occurrence

Menatetrenone (vitamin K2) is widely found in green leaves and vegetables, and also in fish, meat, cheese and liver oil.

Uses

Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 4 has four isoprene residue in its side chain and is also commonly refered to as menatetrenone. Menaquinone-4 is the most common type of vitamin K2 and is known as a hemostatic agent and is used as adjunctive therapy for the pain of osteoporosis.

Definition

ChEBI: Menaquinone-4 is a menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration. It has a role as a bone density conservation agent, a human metabolite, an antioxidant, an anti-inflammatory agent and a neuroprotective agent.

Preparation

It can be extracted from millet leaves and rotten fish, and can also be synthesized with 2-menaquinone-1,4.

General Description

Menaquinone (K2), a vitamin K2 homologue with four isoprene units. It has been reported to enhance bone formation and plays a vital role in the production of blood coagulation factors.

Biochem/physiol Actions

Menatetrenone (MK-4) is one of nine forms of vitamin K2 which is ubiquitously present in extrahepatic tissues. MK-4 has a number of metabolic and anti-neoplastic activities.

References

https://pubchem.ncbi.nlm.nih.gov/compound/menatetrenone#section=Biomolecular-Interactions-and-Pathways
https://en.wikipedia.org/wiki/Menatetrenone

Menatetrenone Preparation Products And Raw materials

Raw materials

Preparation Products

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Menatetrenone Suppliers

Shanghai Reson biotech Co., Ltd
Tel
021-56916686
Fax
021-61532877
Email
info@vk-2.com
Country
China
ProdList
14
Advantage
58
Zhengzhou anmousse chemical products co. LTD
Tel
0371-55289822 18737195735
Fax
QQ:483339295
Email
483339295@qq.com
Country
China
ProdList
7073
Advantage
58
Wuhan Dingtong Pharmaceutical Co., Ltd
Tel
027-027-59207795 18327179646
Fax
027-59207795
Email
18327179646@163.com
Country
China
ProdList
1943
Advantage
58
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
3974
Advantage
58
Jiangxi ravel Biotechnology Co.,Ltd
Tel
400-880-2824 18107960669
Fax
18140514863
Email
bd@ruiweier.cn
Country
China
ProdList
995
Advantage
58
Hubei Xingcheng Biotechnology Co., Ltd
Tel
19171210221
Fax
QQ:3505191060
Email
3371991952@qq.com
Country
China
ProdList
961
Advantage
58
ZHENGZHOU TAIFENG PHARMACEUTICAL CO.,LTD
Tel
182-3786-0830 19913859908
Email
290833579@qq.com
Country
China
ProdList
534
Advantage
58
Hangzhou Weitai Biological Pharmaceutical Co., Ltd.
Tel
0571-82358004 13588879771
Email
info@weitai-pharmaceutical.com
Country
China
ProdList
81
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2210
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
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View Lastest Price from Menatetrenone manufacturers

Shanghai Affida new material science and technology center
Product
Menatetrenone 863-61-6
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99
Supply Ability
10 tons
Release date
2024-03-19
Nantong Guangyuan Chemicl Co,Ltd
Product
Vitamin K2 863-61-6
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-12-01
Henan Tengmao Chemical Technology Co. LTD
Product
Menatetrenone 863-61-6
Price
US $110.00-90.00/kilogram
Min. Order
1kilogram
Purity
99%
Supply Ability
10 tons/per week
Release date
2024-01-09

863-61-6, MenatetrenoneRelated Search:


  • MENATETRENONE
  • MENAQUINONE 4
  • MENAQUINONE
  • 1,4-naphthoquinone,2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen
  • 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthoqu
  • 2-methyl-3-trans-tetraprenyl-1,4-naphthoquinone
  • e3100
  • k2(sub20)
  • menatetranone
  • Menaquinone4, Menatetrenone
  • Menaquinone4, Menatetrenone, VitaminK2
  • 2-Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-1,4-naphthoquinone
  • Menaquinone K4
  • Vitamin MK-4
  • D00100
  • Menatetrenone (jp15/inn)
  • Vitamin K2 (tn)
  • menaquinon-4
  • VITAMIN K2(MENAQUINONE-4)(SH)
  • Vitamin K2(MK-4)
  • Metetrenone
  • Vitamin K2 (MK-4) solution
  • Vitamin K2(20),MK4 0.13%
  • Vitamin K2(20),MK4 1.3% oil
  • Vitamin K2(20),MK4 1.3% powder
  • Vitamin K2(20),MK-4 JP14 powder
  • 2-Methyl-3-geranylgeranyl-1,4-naphthoquinone
  • Glakay
  • Menaquinone 4 (Mixture of cis-trans isoMers)
  • Menatetrenone(11032-49-8)
  • kaytwo
  • menaquinonek(sub4)
  • mk(sub4)
  • vitamink2(sub20)
  • Phytonadione,(Z)
  • MENAQUINONE (K2) 100MG NEAT
  • VitaminK2(20)0.13%Oil
  • VitaminK2(45)98.0%Min.Powder
  • VitaminK2(20)
  • VitaminK2(20)1.3%Powder
  • VitaminK2(20)98.0%Oil
  • VitaminK2(20)98.0%Powder
  • VitaminK2(20)0.13%Powder
  • VitaminK2(20)1.3%Oil
  • (E,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione
  • 2-Methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl]naphthalene-1,4-dione
  • Vitamin K2
  • Vitamin K2(20),MK4 0.13% powder
  • Vitamin K2,MK4,menaquinone, menaquinon-4, menatetrenone, menatetren, menatetrenona, menatetrenonum
  • Vitamin K2-Menatetrenone ( MK-4 )
  • Menatetrenone (MK-4)
  • vitamin K2 Menatetrenone
  • Menatetrenone RS
  • Menaquinone-4 Standard
  • 1,4-Naphthalenedione, 2-methyl-3-[(2E,6E,10E)-3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen-1-yl]-
  • Menatetrenone USP/EP/BP
  • 2-Methyl-3-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)naphthalene-1,4-dione
  • Menatetrenone (Vitamin MK4, E3100)