ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate

Application

Product Name: ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate
CAS No.: 800401-67-6
Chemical Name: ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate
Synonyms: 3-c]pyridine-2-carboxylate;ethyl 5-chloro-1H-pyrrolo[2;5-Chloro-6-azaindole-2-carboxylic acid ethyl ester;ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate;5-chloro-1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester;1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid, 5-chloro-, ethyl ester
CBNumber: CB31562386
Molecular Formula: C10H9ClN2O2
Formula Weight: 224.64
MOL File: 800401-67-6.mol

More

Less

ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate Property

Boiling point:: 406.0±40.0 °C(Predicted)
Density: 1.391±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 11.76±0.40(Predicted)
Appearance: Light yellow to light brown Solid

More

Less

Safety

HazardClass: IRRITANT

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: E903503
Product name: Ethyl5-Chloro-1h-pyrrolo[2,3-c]pyridine-2-carboxylate
Packaging: 100mg
Price: $165
Updated: 2021/12/16

TRC

Product number: E903503
Product name: Ethyl5-Chloro-1h-pyrrolo[2,3-c]pyridine-2-carboxylate
Packaging: 250mg
Price: $345
Updated: 2021/12/16

AK Scientific

Product number: W8525
Product name: Ethyl5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate
Packaging: 500mg
Price: $348
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0360249
Product name: ETHYL-5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $501.45
Updated: 2021/12/16

Matrix Scientific

Product number: 057529
Product name: Ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate
Purity: 98%
Packaging: 500mg
Price: $221
Updated: 2021/12/16

More

Less

ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate Chemical Properties,Usage,Production

Application

Ethyl 5-chloro-6-azaindole-2-carboxylate is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes as well as in chemical and pharmaceutical research and development.

Synthesis

800401-66-5

800401-67-6

Step 2: Synthesis of ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 10-b To a solution of 3-(2-chloro-5-nitropyridin-4-yl)-2-oxopropanoic acid ethyl ester 10-a (2.726 g, 10 mmol) in THF (80 mL) and EtOH (30 mL) was added a saturated ammonium chloride solution (50 mL). Subsequently, iron powder (2.747 g, 4.9 eq.) was added in batches at room temperature under vigorous stirring, and then the mixture was heated to reflux for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature, filtered through diatomaceous earth and washed with warm THF/ethanol (1:1, v/v). The filtrate was evaporated and the residue was dissolved in 100 mL of water with stirring and refluxing. The resulting precipitate was thermally filtered, washed twice with warm water and then dried under vacuum to give ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 10-b (1.9 g, 84% yield). m/z = 225 (M + H)+; 1H NMR (400 MHz, DMSO-d6) δ ppm: 1.36 (t, J = 6.8 Hz, 3H), 4.39 (q, J = 6.7 Hz, 2H), 7.15 (s, 1H), 7.76 (s, 1H), 8.64 (s, 1H), 12.59 (br s, 1H).

References

[1] Patent: WO2012/80450, 2012, A1. Location in patent: Page/Page column 24
[2] Molecules, 2014, vol. 19, # 9, p. 13342 - 13357
[3] Patent: WO2006/59164, 2006, A2. Location in patent: Page/Page column 20
[4] Patent: WO2006/67532, 2006, A1. Location in patent: Page/Page column 19
[5] Patent: US2008/125459, 2008, A1. Location in patent: Page/Page column 9

ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate Suppliers

China 93 China Hong Kong 1 Germany 2 India 2 United States 12 Global 110

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

ChemFuture PharmaTech (Jiangsu) Ltd

Tel: 5108538618
Fax: 86 510 85386988-8017
Email: suger.wang@chemfuture.com
Country: China
ProdList: 832
Advantage: 65

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shangchem Co., Ltd.

Tel: +86-21-68182121
Fax: +86-21-68182121
Country: China
ProdList: 882
Advantage: 52

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

skychemical Co.Ltd

Tel: 021-20958197 20965099
Fax: 021-20960837
Email: sales@skychemical.com
Country: China
ProdList: 1183
Advantage: 57

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

NovoChemy Ltd.

Tel: 021-31261262/ 49 (0)17662837245
Fax: (0)21-33250524
Email: sales@novochemy.com
Country: Germany
ProdList: 6328
Advantage: 58

More

Less

View Lastest Price from ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate manufacturers

Career Henan Chemical Co

Product: ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 800401-67-6
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-12

800401-67-6, ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylateRelated Search:

5-Chloro-1H-pyrazolo[3,4-b]pyridine 5-Chloro-1H-pyrazolo[4,3-b]pyridine 1-(5-Bromo-7-azaindole)ethanone Ethanone, 1-(1H-pyrrolo[2,3-c]pyridin-3-yl)- (9CI) ethyl 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carboxylate 4-BroMo-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 5-AZAINDOLE-2-CARBOXYLIC ACID 3-Cyano-4-azaindole 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 5-chloro- 1H-PYRROLO[3,2-C]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER ethyl 5-chloro-1H-pyrrolo[3,2-b]pyridine-2-carboxylate 1H-Pyrrolo[2,3-b]pyridine, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- 1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE 1H-PYRROLO[2,3-C]PYRIDINE-2-CARBALDEHYDE

ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate

5-Chloro-6-azaindole-2-carboxylic acid ethyl ester

3-c]pyridine-2-carboxylate

ethyl 5-chloro-1H-pyrrolo[2

5-chloro-1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester

1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid, 5-chloro-, ethyl ester

800401-67-6

CHIRAL CHEMICALS