ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate
Application- Product Name
- ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate
- CAS No.
- 800401-67-6
- Chemical Name
- ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate
- Synonyms
- 3-c]pyridine-2-carboxylate;ethyl 5-chloro-1H-pyrrolo[2;5-Chloro-6-azaindole-2-carboxylic acid ethyl ester;ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate;5-chloro-1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid ethyl ester;1H-Pyrrolo[2,3-c]pyridine-2-carboxylic acid, 5-chloro-, ethyl ester
- CBNumber
- CB31562386
- Molecular Formula
- C10H9ClN2O2
- Formula Weight
- 224.64
- MOL File
- 800401-67-6.mol
ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate Property
- Boiling point:
- 406.0±40.0 °C(Predicted)
- Density
- 1.391±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 11.76±0.40(Predicted)
- Appearance
- Light yellow to light brown Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- E903503
- Product name
- Ethyl5-Chloro-1h-pyrrolo[2,3-c]pyridine-2-carboxylate
- Packaging
- 100mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- E903503
- Product name
- Ethyl5-Chloro-1h-pyrrolo[2,3-c]pyridine-2-carboxylate
- Packaging
- 250mg
- Price
- $345
- Updated
- 2021/12/16
- Product number
- W8525
- Product name
- Ethyl5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate
- Packaging
- 500mg
- Price
- $348
- Updated
- 2021/12/16
- Product number
- HCH0360249
- Product name
- ETHYL-5-CHLORO-1H-PYRROLO[2,3-C]PYRIDINE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.45
- Updated
- 2021/12/16
- Product number
- 057529
- Product name
- Ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate
- Purity
- 98%
- Packaging
- 500mg
- Price
- $221
- Updated
- 2021/12/16
ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate Chemical Properties,Usage,Production
Application
Ethyl 5-chloro-6-azaindole-2-carboxylate is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes as well as in chemical and pharmaceutical research and development.
Synthesis
800401-66-5
800401-67-6
Step 2: Synthesis of ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 10-b To a solution of 3-(2-chloro-5-nitropyridin-4-yl)-2-oxopropanoic acid ethyl ester 10-a (2.726 g, 10 mmol) in THF (80 mL) and EtOH (30 mL) was added a saturated ammonium chloride solution (50 mL). Subsequently, iron powder (2.747 g, 4.9 eq.) was added in batches at room temperature under vigorous stirring, and then the mixture was heated to reflux for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature, filtered through diatomaceous earth and washed with warm THF/ethanol (1:1, v/v). The filtrate was evaporated and the residue was dissolved in 100 mL of water with stirring and refluxing. The resulting precipitate was thermally filtered, washed twice with warm water and then dried under vacuum to give ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 10-b (1.9 g, 84% yield). m/z = 225 (M + H)+; 1H NMR (400 MHz, DMSO-d6) δ ppm: 1.36 (t, J = 6.8 Hz, 3H), 4.39 (q, J = 6.7 Hz, 2H), 7.15 (s, 1H), 7.76 (s, 1H), 8.64 (s, 1H), 12.59 (br s, 1H).
References
[1] Patent: WO2012/80450, 2012, A1. Location in patent: Page/Page column 24
[2] Molecules, 2014, vol. 19, # 9, p. 13342 - 13357
[3] Patent: WO2006/59164, 2006, A2. Location in patent: Page/Page column 20
[4] Patent: WO2006/67532, 2006, A1. Location in patent: Page/Page column 19
[5] Patent: US2008/125459, 2008, A1. Location in patent: Page/Page column 9
ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate manufacturers
- Product
- ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate 800401-67-6
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12