1-(5-Bromo-7-azaindole)ethanone
- Product Name
- 1-(5-Bromo-7-azaindole)ethanone
- CAS No.
- 866545-96-2
- Chemical Name
- 1-(5-Bromo-7-azaindole)ethanone
- Synonyms
- 3-Acetl-5-bromo-7-azaindole;1-(5-Bromo-7-azaindole)ethanone;1-(5-BROMO-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)-ETHANONE;1-{5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl}ethan-1-one;Ethanone, 1-(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)-
- CBNumber
- CB92485417
- Molecular Formula
- C9H7BrN2O
- Formula Weight
- 239.07
- MOL File
- 866545-96-2.mol
1-(5-Bromo-7-azaindole)ethanone Property
- Density
- 1.674±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.29±0.40(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 4H56-9-3B
- Product name
- 1-{5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl}ethan-1-one
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $290
- Updated
- 2021/12/16
- Product number
- HCH0362009
- Product name
- 1-(5-BROMO-1H-PYRROLO[2,3-B]PYRIDIN-3-YL)ETHANONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.89
- Updated
- 2021/12/16
- Product number
- 4H56-9-3B
- Product name
- 1-{5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl}ethan-1-one
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $790
- Updated
- 2021/12/16
- Product number
- 4H56-9-3B
- Product name
- 1-{5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl}ethan-1-one
- Purity
- 97.0%
- Packaging
- 5G
- Price
- $1200
- Updated
- 2021/12/16
- Product number
- 3023AH
- Product name
- 1-(5-Bromo-1H-pyrrolo[2,3-B]pyridin-3-yl)ethanone
- Packaging
- 5g
- Price
- $2500
- Updated
- 2021/12/16
1-(5-Bromo-7-azaindole)ethanone Chemical Properties,Usage,Production
Synthesis
75-36-5
183208-35-7
866545-96-2
Step 1: Synthesis of 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone. 5-Bromo-1H-pyrrolo[2,3-b]pyridine (2.00 g, 10.15 mmol) was added to a suspension of aluminum chloride (6.77 g, 50.75 mmol) in stirred anhydrous dichloromethane (100 mL) under nitrogen protection. The reaction mixture was stirred at room temperature for 1 h, followed by slow dropwise addition of acetyl chloride (3.61 mL, 50.75 mmol). After the dropwise addition was completed, the reaction solution was continued to be stirred for 5 hours. Upon completion of the reaction, the mixture was cooled to 0 °C in an ice bath and methanol was added slowly until the solution was clarified to quench the reaction. The reaction solution was concentrated under reduced pressure, water was added and the pH was adjusted dropwise to 4 by addition of 1 N sodium hydroxide solution.The product was extracted with ethyl acetate and the organic layer was washed with saturated potassium sodium tartrate solution to remove residual aluminum salts. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was redissolved in ethyl acetate and filtered through a silica gel bed. The filtrate was concentrated to afford 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone as an orange solid (2.25 g, 93% yield).1H NMR (500 MHz, d6-DMSO) δ 12.70 (br s, 1H), 8.56 (d, J = 2.5 Hz, 1H), 8.55 (s, 1H), 8.40 (d , J = 2.5 Hz, 1H), 2.46 (s, 3H). Mass spectrum: m/z 238.9/240.9 (M + H+).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 24, p. 7212 - 7215
[2] Patent: US2006/30583, 2006, A1. Location in patent: Page/Page column 61-62
[3] Patent: WO2008/124849, 2008, A2. Location in patent: Page/Page column 77-78
[4] Patent: US2008/261921, 2008, A1. Location in patent: Page/Page column 141-142
[5] Patent: US2011/82138, 2011, A1. Location in patent: Page/Page column 65
1-(5-Bromo-7-azaindole)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(5-Bromo-7-azaindole)ethanone manufacturers
- Product
- 1-(5-Bromo-7-azaindole)ethanone 866545-96-2
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12