6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE
- Product Name
- 6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE
- CAS No.
- 143468-13-7
- Chemical Name
- 6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE
- Synonyms
- 6-broMo-;6-BROMO-7-AZAINDOLE;6-broMo-1H-pyrrolo[2;6-Bromo-7-azaindole,96%;6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE;1H-Pyrrolo[2,3-b]pyridine, 6-bromo-
- CBNumber
- CB1434398
- Molecular Formula
- C7H5BrN2
- Formula Weight
- 197.03
- MOL File
- 143468-13-7.mol
6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE Property
- Melting point:
- 192-195℃
- Boiling point:
- 438.7±37.0 °C(Predicted)
- Density
- 1.79±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 6.76±0.40(Predicted)
- form
- Solid
- color
- Off-white to yellow
- InChI
- InChI=1S/C7H5BrN2/c8-6-2-1-5-3-4-9-7(5)10-6/h1-4H,(H,9,10)
- InChIKey
- LKXJGVGBEDEAAW-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=CC=C(Br)N=2
- CAS DataBase Reference
- 143468-13-7
Safety
- Safety Statements
- 24/25
- RIDADR
- UN2811
- HazardClass
- 6.1
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B687178
- Product name
- 6-Bromo-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 2.5g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- B687178
- Product name
- 6-Bromo-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
- Product number
- JK535891
- Product name
- 6-Bromo-7-azaindole
- Purity
- 97%
- Packaging
- 250mg
- Price
- $148
- Updated
- 2021/12/16
- Product number
- 073194
- Product name
- 6-Bromo-7-azaindole
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 073194
- Product name
- 6-Bromo-7-azaindole
- Purity
- 95+%
- Packaging
- 1g
- Price
- $59
- Updated
- 2021/12/16
6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE Chemical Properties,Usage,Production
Chemical Properties
6-Bromo-1H-pyrrolo[2,3-B]pyridine has high chemical transformation properties, and it has been reported in the literature that the bromine atoms in the structure of the substance can be cross-coupled with metal-organic reagents or metal-organic reagents under the action of metal-palladium catalysts. It is worth noting that the substance is sensitive to oxidants, and its pyrrole and pyridine units are easily oxidized to the corresponding nitrogen oxides when exposed to oxidants.
Uses
6-Bromo-1H-pyrrolo[2,3-B]pyridine has high chemical conversion performance. Relevant literature reports that the bromine atom in the structure of this substance can undergo cross-coupling reaction with metal organic reagents or metal-like organic reagents under the action of metal palladium catalyst.
Synthesis
143468-12-6
143468-13-7
Step 2: To a solution of 1-benzoyl-6-bromo-1H-pyrrolo[2,3-b]pyridine (0.046 g, 0.15 mmol) in methanol (5.0 mL) was added 5 N aqueous sodium hydroxide solution (1.0 mL). The reaction mixture was stirred at room temperature for 2 hours. After the reaction was completed, the solvent was removed by concentration under reduced pressure. The residue was extracted with ether (3 × 10 mL) and the organic layers were combined and washed sequentially with water (10 mL) and saturated sodium chloride solution (10 mL). The organic layer was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 6-bromo-1H-pyrrolo[2,3-b]pyridine (0.028 g, 95% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 7.01 (d, J = 8.1 Hz, 1H), 7.46 (d, J = 8.1 Hz, 1H), 7.75 (d, J = 8.1 Hz, 1H), 8.51 (d, J = 8.1 Hz, 1H).
References
[1] Synthesis, 1992, # 7, p. 661 - 663
[2] Patent: EP2565192, 2013, A1. Location in patent: Paragraph 0283
[3] Patent: WO2011/128455, 2011, A1. Location in patent: Page/Page column 83
[4] Patent: US2011/280808, 2011, A1. Location in patent: Page/Page column 39
[5] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 6, p. 1405 - 1411
6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE manufacturers
- Product
- 6-BROMO-1H-PYRROLO[2,3-B]PYRIDINE 143468-13-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-06-24