5-Bromopyridine-2-carbaldehyde

Product Name: 5-Bromopyridine-2-carbaldehyde
CAS No.: 31181-90-5
Chemical Name: 5-Bromopyridine-2-carbaldehyde
Synonyms: 5-BROMOPICOLINALDEHYDE;5-BROMO-2-PYRIDINECARBOXALDEHYDE;5-BROMO-PYRIDINE-2-CARBALDEHYDE;2-Formyl-5-Bromopyridine;5-Bromo-2-formylpyridine, 5-Bromo-2-picolinaldehyde;5-BROMO-2-FORMYLPYRIDINE;5-Bromopyridine-2-carbaL;5-Bromo-2-picolinaldehyde;5-Bromo-2-Pyridinaldehyde;5-BroM-3-pyridincarbaldehyd
CBNumber: CB8352244
Molecular Formula: C6H4BrNO
Formula Weight: 186.01
MOL File: 31181-90-5.mol

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5-Bromopyridine-2-carbaldehyde Property

Melting point:: 91-96 °C
Boiling point:: 70°C/26mmHg(lit.)
Density: 1.683±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 1.36±0.10(Predicted)
form: powder to crystal
color: White to Light yellow to Light orange
Water Solubility: Insoluble in water.
Sensitive: Air Sensitive
InChI: InChI=1S/C6H4BrNO/c7-5-1-2-6(4-9)8-3-5/h1-4H
InChIKey: ZQVLPMNLLKGGIU-UHFFFAOYSA-N
SMILES: C1(C=O)=NC=C(Br)C=C1
CAS DataBase Reference: 31181-90-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-20/21/22
Safety Statements: 22-26-36/37/39-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 694177
Product name: 5-Bromo-2-pyridinecarboxaldehyde
Purity: 95%
Packaging: 1g
Price: $84.2
Updated: 2025/07/31

TCI Chemical

Product number: B3489
Product name: 5-Bromo-2-pyridinecarboxaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $30
Updated: 2025/07/31

Oakwood

Product number: 040402
Product name: 5-Bromopyridine-2-carbaldehyde
Packaging: 5g
Price: $30
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H15-9-01
Product name: 5-Bromo-2-formylpyridine
Purity: 98%
Packaging: 25g
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: 0643AP
Product name: 5-Bromopyridine-2-carbaldehyde,tech.
Packaging: 100g
Price: $120
Updated: 2021/12/16

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5-Bromopyridine-2-carbaldehyde Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

5-Bromopyridine-2-carboxaldehyde is used as organic chemical synthesis intermediate.

Synthesis

624-28-2

68-12-2

31181-90-5

5-Bromo-2-pyridinecarboxaldehyde was synthesized according to General Method C using 2,5-dibromopyridine and N,N-dimethylformamide (DMF) as raw materials. The specific operation was as follows: 2,5-dibromopyridine (237 mg, 1 mmol) was mixed with DMF (115 μL, 1.5 mmol) for the reaction. After completion of the reaction, the crude product was purified by fast column chromatography (eluent: hexane/ethyl acetate = 10:1) to afford the target compound 5-bromo-2-pyridinecarboxaldehyde (27b) as a brown solid (149 mg, 80% yield). Thin layer chromatography (TLC) analysis showed an Rf value of 0.45 (Expander: hexane/ethyl acetate = 8:1). Nuclear magnetic resonance hydrogen spectroscopy (1H NMR, 400 MHz, CDCl3) data were as follows: δ 10.03 (1H, s), 8.85 (1H, dd, J = 0.8, 2.0 Hz), 8.02 (1H, ddd, J = 0.8, 2.0, 8.0 Hz), 7.85 (1H, dd, J = 0.8, 8.0 Hz). The nuclear magnetic resonance carbon spectrum (13C NMR, 100 MHz, CDCl3) data were as follows: δ 192.4, 151.7, 151.3, 140.0, 126.3, 122.8. The spectral data obtained were in agreement with literature reports.

References

[1] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 22, p. 5852 - 5869
[2] Patent: WO2007/15744, 2007, A1. Location in patent: Page/Page column 58-59
[3] Chemistry - A European Journal, 2006, vol. 12, # 13, p. 3472 - 3483
[4] Patent: WO2006/22794, 2006, A1. Location in patent: Page/Page column 49
[5] Tetrahedron Letters, 2000, vol. 41, # 22, p. 4335 - 4338

5-Bromopyridine-2-carbaldehyde Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 3-Chloroperoxybenzoic acid Triethylamine Chloroform Trifluoroacetic anhydride Ethyl acetate 5-Bromo-2-methylpyridine Methanol Oxalyl chloride Sodium thiosulfate pentahydrate

Preparation Products

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5-Bromopyridine-2-carbaldehyde Suppliers

Americas 1 Belgium 1 China 334 Europe 3 France 1 Germany 5 India 24 Japan 2 Slovakia 2 South Korea 1 Switzerland 3 Ukraine 1 United Kingdom 8 United States 46 Global 432

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View Lastest Price from 5-Bromopyridine-2-carbaldehyde manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Bromo-2-pyridinecarbaldehyde 31181-90-5
Price: US $1.10-9.90/KG
Min. Order: 1KG
Purity: 99% min
Supply Ability: 100kg
Release date: 2025-08-18

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Bromopyridine-2-carbaldehyde 31181-90-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-06-07

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Bromopyridine-2-carbaldehyde 31181-90-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

31181-90-5, 5-Bromopyridine-2-carbaldehydeRelated Search:

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31181-90-5

31181-07-2

Aldehyde

pharmacetical

Aldehyde

Building Blocks

Carbonyl Compounds

Heterocycles

Aldehydes

blocks

Bromides

Pyridines

Pyridine

Pyridine Series

31181-90-5