ChemicalBook > CAS DataBase List > 2-Pyridinecarboxaldehyde
2-Pyridinecarboxaldehyde
- Product Name
- 2-Pyridinecarboxaldehyde
- CAS No.
- 1121-60-4
- Chemical Name
- 2-Pyridinecarboxaldehyde
- Synonyms
- PICOLINALDEHYDE;PYRIDINE-2-ALDEHYDE;PYRIDINE-2-CARBOXALDEHYDE;PYRIDINE-2-CARBALDEHYDE;2-Pyridinecarboxyaldehyde;2-FORMYLPYRIDINE;2-PYRIDINECARBALDEHYDE;Pyridine-2-formaldehyde;2-PA;Picolinal
- CBNumber
- CB0153722
- Molecular Formula
- C6H5NO
- Formula Weight
- 107.11
- MOL File
- 1121-60-4.mol
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2-Pyridinecarboxaldehyde Property
- Melting point:
- -21--22°C
- Boiling point:
- 181 °C(lit.)
- Density
- 1.126 g/mL at 25 °C(lit.)
- vapor pressure
- 73Pa at 20℃
- refractive index
- n20/D 1.536(lit.)
- Flash point:
- 130 °F
- storage temp.
- 2-8°C
- form
- liquid (strong colored)
- pka
- 3.8(at 20℃)
- color
- Clear yellow to yellow-brown
- PH
- 6.5 (111g/l, H2O, 20℃)
- Water Solubility
- miscible
- Sensitive
- Air Sensitive
- BRN
- 105341
- InChIKey
- CSDSSGBPEUDDEE-UHFFFAOYSA-N
- LogP
- 0.714 at 20.5℃
- CAS DataBase Reference
- 1121-60-4(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Pyridinecarboxaldehyde(1121-60-4)
- EPA Substance Registry System
- 2-Pyridinecarboxaldehyde (1121-60-4)
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Safety
- Hazard Codes
- Xn,Xi,N,T,F
- Risk Statements
- 10-22-36/37/38-51/53-46-43-34-23-52
- Safety Statements
- 7-26-36-61-53-45-36/37/39-29-16-36/37
- RIDADR
- UN 1989 3/PG 3
- WGK Germany
- 3
- F
- 8-10-23
- Hazard Note
- Irritant/Keep Cold/Air Sensitive
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29333999
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H317May cause an allergic skin reaction
H318Causes serious eye damage
H330Fatal if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- P62003
- Product name
- 2-Pyridinecarboxaldehyde
- Purity
- 99%
- Packaging
- 25g
- Price
- $38.8
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- P62003
- Product name
- 2-Pyridinecarboxaldehyde
- Purity
- 99%
- Packaging
- 100g
- Price
- $82
- Updated
- 2024/03/01
TCI Chemical
- Product number
- P0425
- Product name
- 2-Pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $68
- Updated
- 2024/03/01
TCI Chemical
- Product number
- P0425
- Product name
- 2-Pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 100g
- Price
- $166
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A11391
- Product name
- Pyridine-2-carboxaldehyde, 99%
- Packaging
- 25g
- Price
- $38.6
- Updated
- 2024/03/01
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2-Pyridinecarboxaldehyde Chemical Properties,Usage,Production
Chemical Properties
Yellow liquid
Uses
2-Pyridinecarboxaldehyde has been used:
- To synthesize chitosan based bifunctionalized adsorbent.
- In the aldol addition reaction with pyruvate in the presence of 2-keto-3-deoxy-6-phosphogluconate aldolase (KDPG) catalyst to form (S)-4-hydroxy-2-keto-4-(2′-pyridyl)butyrate.
- In the condensation reaction with (S)-(?)-α-methylbenzylamine and (R)-(+)-α-methylbenzylamine to synthesize two chiral (S)-(?)- and (R)-(+)Schiff base compounds.
It can also be combined with thiosemicarbazide to form 2-pyridinecarboxaldehyde thiosemicarbazone ligand (L) which can further complex with Ni(II) and Cu(II) salts (MX) to form [M(L)2X2] complexes.
Definition
ChEBI: 2-Pyridinecarboxaldehyde is a pyridinecarbaldehyde that is pyridine in which the hydrogen at position 2 is replaced by a formyl group.
Synthesis Reference(s)
Synthetic Communications, 23, p. 1775, 1993 DOI: 10.1080/00397919308011276
Purification Methods
Purification is achieved by bubbling sulfur dioxide into a solution of 50g of the aldehyde in 250mL of boiled water, under nitrogen, at 0o, until precipitation is complete. The bisulfite addition compound is filtered off rapidly and, after washing with a little water, is refluxed in 17% HCl (200mL) under nitrogen until a clear solution is obtained. Neutralisation with NaHCO3 and extraction with ether separated the aldehyde which is recovered by drying the extract, then distilling twice, under nitrogen. [Kyte et al. J Chem Soc 4454 1960, Beilstein 21 I 287, 21 III/IV 3495, 21/7 V 293.]
2-Pyridinecarboxaldehyde Preparation Products And Raw materials
Raw materials
acetonitrile
N,N-Dimethylformamide
Acetone
2-Picoline
2-Bromopyridine
Sodium sulfate
Sodium chloride
Toluene
Chromium(VI) oxide
Tetrahydrofuran
Diethyl ether
Hydrochloric acid
Dichloromethane
Methanol
Pyridine
PETROLEUM ETHER
n-Butyllithium
Preparation Products
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2-Pyridinecarboxaldehyde Suppliers
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View Lastest Price from 2-Pyridinecarboxaldehyde manufacturers
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
- Product
- 2-Pyridinecarboxaldehyde 1121-60-4
- Price
- US $100.00-75.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000Ton
- Release date
- 2024-08-13
Hebei Dangtong Import and export Co LTD
- Product
- 2-Pyridinecarboxaldehyde 1121-60-4
- Price
- US $122.00-110.00/kilograms
- Min. Order
- 100kilograms
- Purity
- 99%
- Supply Ability
- 100tons
- Release date
- 2023-02-17
Hebei Weibang Biotechnology Co., Ltd
- Product
- 2-Pyridinecarboxaldehyde 1121-60-4
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-02
1121-60-4, 2-PyridinecarboxaldehydeRelated Search:
3-PYRIDINECARBOXALDEHYDE
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1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one
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Pyridine sulfur trioxide
Pyridine-2-carbonyl chloride hydrochloride
Pyridine-4-boronic acid
3-Pyridylboronic acid
2-(Hydroxymethyl)pyridine
2-Picolinic acid
4-Cyanopyridine
2,6-Pyridinedicarbonitrile
3,4-Pyridinedicarboxylic acid
2-Cyanopyridine
Quinaldic acid
PICOLINIC ACID N-OXIDE
Pyridine-2,6-dicarboxylic acid
2-Acetylpyridine